Role of vitamin D deficiency in type 2 diabetes mellitus and diabetic neuropathy development
https://doi.org/10.14341/DM9583
Abstract
Type 2 diabetes mellitus (DM) is a global epidemic associated with severe vascular complications development. Diabetic neuropathy is the most common chronic complication of DM that worsens patients’ life quality and prognosis. Therefore, studies dealing with DM and diabetic neuropathy underlying mechanisms are extremely relevant. The review discusses current views on vitamin D role in glucose metabolism and inflammatory processes. It is reported that vitamin D deficiency can contribute to insulin resistance development, and change in vitamin D receptor activity or extra- and intracellular calcium concentration due to vitamin D deficiency can affect pancreatic β-cells function and lead to decrease in insulin production. Key pathogenic mechanisms of diabetic neuropathy as well as possible relationship between vitamin D deficiency and neuropathy development are in focus of this review. Results of recent clinical trials regarding vitamin D supplementation in patients with DM are also discussed. The presented data suggest that vitamin D deficiency can be considered as a non-classical risk factor for the development of not only DM but its complications as well.
About the Authors
Anna P. StepanovaAcademician I.P. Pavlov First St. Petersburg State Medical University
Russian Federation
MD, PhD student
Tatiana L. Karonova
Academician I.P. Pavlov First St. Petersburg State Medical University; Almazov National Medical Research Centre
Russian Federation
MD, PhD, Professor
Anna A. Bystrova
Academician I.P. Pavlov First St. Petersburg State Medical University; Almazov National Medical Research Centre
Russian Federation
MD, PhD
Vadim B. Bregovsky
Saint-Petersburg City Diabetes Centre
Russian Federation
MD, PhD
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Stepanova A.P., Karonova T.L., Bystrova A.A., Bregovsky V.B. Role of vitamin D deficiency in type 2 diabetes mellitus and diabetic neuropathy development. Diabetes mellitus. 2018;21(4):301-306. https://doi.org/10.14341/DM9583
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