Results of the ADVANCE trial and interventional observational program ADVANCE-ON: whether our understanding of the relationship of glycemic factors and the risk of vascular complications in patients with type 2 diabetes has changed?
https://doi.org/10.14341/DM7696
Abstract
The results from the analysis of the ADVANCE trial and post-intervention program ADVANCE-ON are presented in this article. These studies are dedicated to study the effect of intensive glycemic control on the incidence of micro- and macrovascular events in patients with type 2 diabetes mellitus and evaluation of long-term results of intensive glycemic control. We discuss the progress of views on the impact of glycemic control on the development of cardiovascular complications. According to the analysis of the research results, gliclazide MR is safe in patients with type 2 diabetes at high risk for cardiovascular complications.
About the Authors
Marina Vladimirovna Shestakova
Endocrinology Research Centre; Sechenov First Moscow State Medical University
Russian Federation
MD, PhD, Professor, correspondence fellow of the Russian Academy of Sciences
Russian Federation
MD, PhD, Professor, correspondence fellow of the Russian Academy of Sciences
Yuriy Shavkatovich Khalimov
Military medical academy of S.M. Kirov
Russian Federation
MD, PhD, Professor
Russian Federation
MD, PhD, Professor
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Supplementary files
Review
For citations:
Shestakova M.V., Khalimov Yu.Sh. Results of the ADVANCE trial and interventional observational program ADVANCE-ON: whether our understanding of the relationship of glycemic factors and the risk of vascular complications in patients with type 2 diabetes has changed? Diabetes mellitus. 2015;18(4):119-124. (In Russ.) https://doi.org/10.14341/DM7696
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