Type 1 diabetes mellitus in children and adolescents of Russian Federation: key epidemiology trends

Aims.
To evaluate key epidemiology trends for type 1 diabetes mellitus (T1DM) in children and adolescents of Russian Federation during 2001?2011 yy.
Materials and Methods.
Dynamics of incidence, prevalence and mortality from T1DM were assessed for national population and, separately, for all federal regions over the 2001?2011 yy. based on the questionnaires developed in the Institute of Paediatric Endocrinology (Endocrinology Research Centre) and data from the State Register of Diabetes Mellitus.
Results.
18,392 children aged 0 to 14 years and 8934 adolescents with T1DM were registered in Russian Federation by 01.01.2012. T1DM incidence in 2011 was estimated at 2407 among children and 1276 among adolescents. Mean T1DM prevalence across the Federation reached 72.8, incidence 12.43 (3.39?14.06) and mortality 0.07 (0.0?0.26) per 100,000 of relevant population (r.p.). Incidence rate for 2001?2011 indicates a 30% increase for past 11 years with average annual increase of 2.82%. According to the prognosis developed from these data, in 5 years T1DM incidence among children will reach 13.61 per 100,000 of r.p. Highest incidence was registered in Ural Federal Region (17.43 per 100,000 of r.p.) that assumed this position from North-Western federal region with 15.42 per 100,000 of r.p. as of 01.01.2010). T1DM incidence in adolescents is estimated at 15.26 per 100,000 r.p. with prevalence of 92.6 per 100,000 r.p. Incidence rate increased by 10.5% during past 6 years with average annual increase of 0.97%.
Conclusion.
This survey indicates that key epidemiological trends for T1DM in children and adolescents of Russian Federation correspond to average world parameters.

diabetes mellitus type 1, children, adolescents, epidemiology, incidence, prevalence, mortality

1. IDF Diabetes Atlas 5th edition. 2012. Available from: http://www.diabetesatlas.org/

2. Gyurus EK, Patterson C, Soltesz G, Hungarian Childhood Diabetes Epidemiology G. Twenty-one years of prospective incidence of childhood type 1 diabetes in Hungary--the rising trend continues (or peaks and highlands?). Pediatric Diabetes. 2012;13(1):21-25. DOI: http://dx.doi.org/10.1111/j.1399-5448.2011.00826.x

3. Эпидемиология сахарного диабета. Пособие для врачей под ред. акад. Дедова И.И. Москва; 2003. с.36. [The epidemiology of diabetes mellitus. Manual for physicians. Ed by Dedov II. Moscow; 2003. p.36.]

4. Дедов ИИ, Сунцов ЮИ, Кудрякова СВ. О Регистре сахарного диабета. Проблемы эндокринологии. 1995;41(3):4-7. [Dedov II, Suntsov YuI, Kudryakova SV. O Registre sakharnogo diabeta. Problemy endokrinologii. 1995;41(3):4-7.]

5. Сунцов ЮИ, Дедов ИИ. Государственный регистр больных сахарным диабетом – основная информационная система для расчета экономических затрат государства на сахарный диабет и их прогнозирование. Сахарный диабет. 2005;(2):2-5. [Suntsov YI, Dedov II. Gosudarstvennyy registr bol'nykh sakharnym diabetom - osnovnaya informatsionnnaya sistema dlya rascheta ekonomicheskikh zatrat gosudarstva na sakharnyy diabet i ikh prognozirovanie. Diabetes mellitus. 2005;(2):2-5.] [Epub]

6. Зайцев ВМ, Лифляндский ВГ, Маринкин ВИ. Прикладная медицинская статистика. Учебное пособие. Санкт-Петербург: Фолиант; 2003. С. 350-381. [Zaytsev VM, Liflyandskiy VG, Marinkin VI. Prikladnaya meditsinskaya statistika. Uchebnoe posobie. Sankt-Peterburg: Foliant; 2003. P. 350-381.]

7. Щербачева ЛН, Ширяева ТЮ, Сунцов ЮИ, Кураева ТЛ. Сахарный диабет 1-го типа у детей российской федерации: распространенность, заболеваемость, смертность. Проблемы эндокринологии. 2007;51(2):24-29. [Shcherbacheva LN, Shiryaeva TYu, Suntsov YuI, Kurayeva TL. Type 1 diabetes in children: Prevalence, morbidity and mortality in the Russian Federation. Problemy endokrinologii. 2007;51(2):24-29.] [Epub]

8. Ширяева ТЮ, Андрианова ЕА, Сунцов ЮИ. Динамика заболеваемости и распространенности сахарного диабета 1 типа у детей в российской федерации в 2001-2007 гг. Сахарный диабет. 2009;(3): 23-27. [Shiryaeva TYu, Andrianova EA, Suntsov YuI. Dynamics of incidence and prevalence of type 1 diabetes mellitus in children in the Russian Federation (2001-2007). Diabetes mellitus. 2009;(3):23-27.] [Epub]

9. Ширяева ТЮ, Андрианова ЕА, Сунцов ЮИ. Динамика основных эпидемиологических показателей сахарного диабета 1 типа у детей в Российской Федерации. Сахарный диабет. 2010;(4):6-11. [Shiryaeva TYu, Andrianova EA, Suntsov YuI. Dynamics of main epidemiological characteristics of type 1 diabetes mellitus in children of the Russian Federation. Diabetes mellitus. 2010;(4):6-11.] [Epub]

10. Koton S, Israel IRSGI. Incidence of type 1 diabetes mellitus in the 0- to 17-yr-old Israel population, 1997–2003. Pediatric Diabetes. 2007;8(2):60-66. DOI: http://dx.doi.org/10.1111/j.1399-5448.2007.00230.x Ehehalt S, Blumenstock G, Willasch AM, Hub R, Ranke MB, Neu A, et al. Continuous rise in incidence of childhood Type 1 diabetes in Germany. Diabetic Medicine. 2008;25(6):755-757. DOI: http://dx.doi.org/10.1111/j.1464-5491.2008.02450.x

11. Svensson J, Lyngaae-Jørgensen A, Carstensen B, Simonsen LB, Mortensen HB, Danish Childhood Diabetes R. Long-term trends in the incidence of type 1 diabetes in Denmark: the seasonal variation changes over time. Pediatric Diabetes. 2009;10(4):248-254. DOI: http://dx.doi.org/10.1111/j.1399-5448.2008.00483.x

12. Teeäär T, Liivak N, Heilman K, Kool P, Šor R, Paal M, et al. Increasing incidence of childhood-onset type 1 diabetes mellitus among Estonian children in 1999–2006. Time trend analysis 1983–2006. Pediatric Diabetes. 2010;11(2):107-110. DOI: http://dx.doi.org/10.1111/j.1399-5448.2009.00535.x

13. Stanescu DE, Lord K, Lipman TH. The epidemiology of type 1 diabetes in children. Endocrinology and Metabolism Clinics of North America. 2012;41(4):679-694. DOI: http://dx.doi.org/10.1016/j.ecl.2012.08.001