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Сахарный диабет

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Возможности применения инсулина детемир при лечении сахарного диабета у беременных: доказанные преимущества и перспективы использования

https://doi.org/10.14341/DM2004150-55

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Аннотация

В последние годы наблюдается рост распространенности гестационного и манифестного сахарного диабета (СД) у беременных женщин при сохраняющемся высоком уровне акушерских осложнений, неонатальной заболеваемости, перинатальной смертности у женщин с различными формами СД в сравнении с популяцией. Также не вызывает сомнения комплексный вклад фетального программирования и генетических факторов в формирование различных патологических состояний в будущем у детей, рожденных от матерей, страдающих СД.

Доказано снижение риска возникновения акушерских осложнений при достижении удовлетворительного контроля гликемии. Улучшенный фармакокинетический и фармакодинамический профиль аналогов инсулина (в том числе минимальная вариабельность действия) позволяют достигать лучшего контроля гликемии при более низком риске гипогликемий в сравнении с человеческими инсулинами. Клинические преимущества детемира были подтверждены в исследованиях у беременных пациенток с СД. Детемир – единственный аналог инсулина длительного действия, изучавшийся в проспективных исследованиях у беременных женщин – доказал свой удовлетворительный профиль безопасности, а также возможность достижения более низкого уровня гликемии натощак и большей зрелости плода на момент родов.

Об авторах

Людмила Александровна Руяткина
ГБОУ ВПО Новосибирский государственный медицинский университет
Россия
Доктор медицинских наук, профессор кафедры неотложной терапии с эндокринологией и профпатологией ФПК и ППв ГБОУ ВПО "Новосибирский государственный медицинский университет Минздрава России"
Конфликт интересов: О конфликте интересов не заявляется


Максим Юрьевич Сорокин
ГБУЗ Новосибирской области Городская клиническая больница №1
Россия
врач-эндокринолог городского диабетологического центра, консультант-эндокринолог роддома в составе ГБУЗ НСО "Городская клиническая больница №1"
Конфликт интересов: О конфликте интересов не заявляется


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Руяткина Л.А., Сорокин М.Ю. Возможности применения инсулина детемир при лечении сахарного диабета у беременных: доказанные преимущества и перспективы использования. Сахарный диабет. 2016;19(2):171-178. https://doi.org/10.14341/DM2004150-55

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Ruyatkina L.A., Sorokin M.Yu. Detemir potential applications in the treatment of diabetes during pregnancy: proven benefits and perspectives. Diabetes mellitus. 2016;19(2):171-178. https://doi.org/10.14341/DM2004150-55

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