Genetics of monegenic forms of diabetes mellitus
https://doi.org/10.14341/2072-0351-6246
Abstract
It is universally recognized that autoimmune type 1 diabetes mellitus (DM) is not the only form of this disease in children. Increasingly more children andadolescents present with DM2, MODY, and rarer syndromal forms of DM. The actual prevalence of DM other than DM1 in children and adolescentsis unknown but may be estimated at 10%. Despite rare occurrence of genetic syndromes, they collectively account for almost 5% of DM cases amongchildren. The rapid upgrowth of molecular biology opens up a wide range of possibilities for designating various symptom complexes as nosologically selfconsistentforms. New genetic syndromes associated with DM are annually described. It is important both to adequately identify and treat manifestationsand complications of these syndromes in children and to provide relevant medico-genetic counseling and recommendations to the parents.Key words: non-immune diabetes mellitus, MODY, Wolfram syndrome, neonatal, syndromal forms
About the Authors
Tamara Leonidovna Kuraeva
Endocrinological Research Centre, Moscow
Russian Federation
Russian Federation
Lyubov' Iosifovna Zil'berman
Endocrinological Research Centre, Moscow
Russian Federation
Russian Federation
Elena Vital'evna Titovich
Endocrinological Research Centre, Moscow
Russian Federation
Russian Federation
Valentina Alexandrovna Peterkova
Endocrinological Research Centre, Moscow
Russian Federation
Russian Federation
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For citations:
Kuraeva T.L., Zil'berman L.I., Titovich E.V., Peterkova V.A. Genetics of monegenic forms of diabetes mellitus. Diabetes mellitus. 2011;14(1):20-27. (In Russ.) https://doi.org/10.14341/2072-0351-6246
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