Functional activity and peripheral insulin resistance in patients with different types of onset of diabetes mellitus
https://doi.org/10.14341/2072-0351-6082
Abstract
Aim.
To evaluate changes in functional activity and insulin resistance (IR) in patients with different types of onset of diabetes mellitus(DM).
Materials and methods.
We examined 166 subjects which were subdivided into 4 study groups and 1 control group. Assessment of totalbeta-cell functional activity and degree of IR (according to HOMA-model) was conducted in patients with different variants of DM onsetand in the group of high risk for type 1 DM.
Results.
The most significant decrease in beta-cell functional activity was found in patients with type 1 diabetes mellitus (HOMA-F 8.9%).Onset of LADA (Latent autoimmune diabetes in adults) and type 2 diabetes mellitus (T2DM) was also characterized by decreasein beta-cell functional activity (HOMA-F 39.2% and 63.9%, respectively), as well as by development of IR: HOMA-IR 3.7 and 7.2,respectively.
Conclusion.
Clinical onset of LADA and T2DM occurs against the background of decreased beta-cell functional activity and compromisedperipheral insulin sensitivity.
To evaluate changes in functional activity and insulin resistance (IR) in patients with different types of onset of diabetes mellitus(DM).
Materials and methods.
We examined 166 subjects which were subdivided into 4 study groups and 1 control group. Assessment of totalbeta-cell functional activity and degree of IR (according to HOMA-model) was conducted in patients with different variants of DM onsetand in the group of high risk for type 1 DM.
Results.
The most significant decrease in beta-cell functional activity was found in patients with type 1 diabetes mellitus (HOMA-F 8.9%).Onset of LADA (Latent autoimmune diabetes in adults) and type 2 diabetes mellitus (T2DM) was also characterized by decreasein beta-cell functional activity (HOMA-F 39.2% and 63.9%, respectively), as well as by development of IR: HOMA-IR 3.7 and 7.2,respectively.
Conclusion.
Clinical onset of LADA and T2DM occurs against the background of decreased beta-cell functional activity and compromisedperipheral insulin sensitivity.
About the Authors
Tatiana Vasil'evna Nikonova
Endocrinology Research Centre, Moscow
Elena Vladimirovna Pekareva
Endocrinology Research Centre, Moscow
Ivan Ivanovich Dedov
Endocrinology Research Centre, Moscow
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Review
For citations:
Nikonova T.V., Pekareva E.V., Dedov I.I. Functional activity and peripheral insulin resistance in patients with different types of onset of diabetes mellitus. Diabetes mellitus. 2012;15(3):24-26. (In Russ.) https://doi.org/10.14341/2072-0351-6082
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