Cardiovascular implications of modern algorithm of hypoglycemic therapy: ?Florentine hypothesis?
https://doi.org/10.14341/2072-0351-6054
Abstract
The modern algorithm of hypoglycemic therapy for patients with type 2 diabetes mellitus (DM2) has been designed to effectively reach the ?target?blood glucose and HbA1c levels associated with the lowest mortality rate.The most popular scheme is combined treatment with metformin andsulfonylureasthatmakes possible the achievement of the ?target? metabolic indices in the majority of DM2 patients. However, specific cardiovascular efficiency ofthis therapy is a matter of controversy. The safest modalities of combined therapy are discussed based on the analysis of relevant epidemiological data.
About the Authors
Andrey Alexeevich Aleksandrov
Endocrinology Research Centre, Moscow
Svetlana Semenovna Kukharenko
Endocrinology Research Centre, Moscow
Maria Nikolaevna Yadrikhinskaya
Endocrinology Research Centre, Moscow
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Review
For citations:
Aleksandrov A.A., Kukharenko S.S., Yadrikhinskaya M.N. Cardiovascular implications of modern algorithm of hypoglycemic therapy: ?Florentine hypothesis? Diabetes mellitus. 2010;13(4):30-37. (In Russ.) https://doi.org/10.14341/2072-0351-6054
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