Incidence and graveness of helicobacter infection in patients with type 2 diabetes mellitus
https://doi.org/10.14341/2072-0351-6020
Abstract
Aim.
To evaluate the frequency of H.pylori infection and efficiency of its eradication in patients with type 2 diabetes mellitus.
Materials and methods.
The study included 40 patients with DM2 and 38 diabetics with chronic gastritis (CG). H.pylori was detected by urease assayusing 13C-urea. The degree of stomach bacterial contamination was assessed by a semiquantitative histological method. Control groups comprisedpatients with gastric ulcer and CG having undisturbed carbohydrate metabolism.
Results.
The frequency of H.pylori infection was virtually identical in patients with and without DM2 regardless of gastric problems. However, comparativeanalysis revealed significant correlation between the graveness of infection and duration of DM2 (r=0.84; p<0.05). The efficiency of H.pylorieradication by first-line therapy in DM2 patients was significantly lower than in controls (p<0.05).
Conclusion.
Frequent intake of antibiotics was a key factor responsible for resistance to eradication therapy. This funding should be taken into accountwhen prescribing anti-helicobacter therapy to patients with DM2.
To evaluate the frequency of H.pylori infection and efficiency of its eradication in patients with type 2 diabetes mellitus.
Materials and methods.
The study included 40 patients with DM2 and 38 diabetics with chronic gastritis (CG). H.pylori was detected by urease assayusing 13C-urea. The degree of stomach bacterial contamination was assessed by a semiquantitative histological method. Control groups comprisedpatients with gastric ulcer and CG having undisturbed carbohydrate metabolism.
Results.
The frequency of H.pylori infection was virtually identical in patients with and without DM2 regardless of gastric problems. However, comparativeanalysis revealed significant correlation between the graveness of infection and duration of DM2 (r=0.84; p<0.05). The efficiency of H.pylorieradication by first-line therapy in DM2 patients was significantly lower than in controls (p<0.05).
Conclusion.
Frequent intake of antibiotics was a key factor responsible for resistance to eradication therapy. This funding should be taken into accountwhen prescribing anti-helicobacter therapy to patients with DM2.
About the Authors
Ashot Musaelovich Mkrtumyan
Russian State Medical University, Moscow
Aleksey Nikolaevich Kazyulin
Russian State Medical University, Moscow
Kermen Ivanovna Bairova
Russian State Medical University, Moscow
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Review
For citations:
Mkrtumyan A.M., Kazyulin A.N., Bairova K.I. Incidence and graveness of helicobacter infection in patients with type 2 diabetes mellitus. Diabetes mellitus. 2010;13(1):77-79. (In Russ.) https://doi.org/10.14341/2072-0351-6020
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