Age-related hypogonadism in men with metabolic syndrome
https://doi.org/10.14341/2072-0351-6012
Abstract
Aim.
To elucidate the relationship between testosterone and SSBG levels in men with age-related hypogonadism and metabolic syndrome.
Materials and methods.
The study included 125 men aged 30-80 years with a diagnosis of age-related hypogonadism. In all the cases, testosterone(T) and SSBG levels were determined, free T fraction calculated, and waist circumference measured. Almost half of the patients (n=56) presentedwith metabolic syndrome (MS) and underwent measurement of basal immunoreactive insulin (IRI).
Results.
Mean age of the patients (n=125) was 54 [46; 65] years, waist circumference 108 [102; 115] cm, total T 8.3 [5.9; 11] nmol/l (norm 12 -33.5), free T 140 [99.6; 184] pmol/l (norm <250), SSBG 38,8 [28.2; 63.2] nmol/l (norm 12.9 - 61.7). Positive correlation was found between thepatients age, total T and SSBG levels (r=0.33, p<0.001 and r=0.39, p<0.001 respectively) as well as between total T and SSBG levels (r=0.48,p?0.001). The patients were divided into 2 groups depending on the presence or absence of MS. Group 1 (MS, n=56) was characterized by lowerlevels of SSBG, total and free T and more pronounced abdominal obesity compared with group 2 (without MS, n=69). 31 patients in group 1 hadmean IRI level of 26,4 [13; 36.6] mcU/ml (norm 2.3 - 26.4). There was no correlation between SSBG and IRI levels. 18 patients had elevated IRIlevels (mean 33.95 [32.4; 62.5] mcU/ml that positively correlated with SSBG levels (r=0.53, p<0.0006).
Conclusion.
Patients with age-related hypogonadism and metabolic syndrome have lower levels of SSBG, total and free T and greater waist circumferencemeasures compared with age-matched patients without MS. Despite lowered SSBG level in group 1 patients, it remains within normallimits and therefore can not be used as a diagnostic marker of age-specific hypogonadism and MS. In patients with these conditions, there isno correlation between SSBG and IRI levels; in hypogonadic patients the SSBG level is unrelated to waist measures regardless of the presenceor absence of MS.
To elucidate the relationship between testosterone and SSBG levels in men with age-related hypogonadism and metabolic syndrome.
Materials and methods.
The study included 125 men aged 30-80 years with a diagnosis of age-related hypogonadism. In all the cases, testosterone(T) and SSBG levels were determined, free T fraction calculated, and waist circumference measured. Almost half of the patients (n=56) presentedwith metabolic syndrome (MS) and underwent measurement of basal immunoreactive insulin (IRI).
Results.
Mean age of the patients (n=125) was 54 [46; 65] years, waist circumference 108 [102; 115] cm, total T 8.3 [5.9; 11] nmol/l (norm 12 -33.5), free T 140 [99.6; 184] pmol/l (norm <250), SSBG 38,8 [28.2; 63.2] nmol/l (norm 12.9 - 61.7). Positive correlation was found between thepatients age, total T and SSBG levels (r=0.33, p<0.001 and r=0.39, p<0.001 respectively) as well as between total T and SSBG levels (r=0.48,p?0.001). The patients were divided into 2 groups depending on the presence or absence of MS. Group 1 (MS, n=56) was characterized by lowerlevels of SSBG, total and free T and more pronounced abdominal obesity compared with group 2 (without MS, n=69). 31 patients in group 1 hadmean IRI level of 26,4 [13; 36.6] mcU/ml (norm 2.3 - 26.4). There was no correlation between SSBG and IRI levels. 18 patients had elevated IRIlevels (mean 33.95 [32.4; 62.5] mcU/ml that positively correlated with SSBG levels (r=0.53, p<0.0006).
Conclusion.
Patients with age-related hypogonadism and metabolic syndrome have lower levels of SSBG, total and free T and greater waist circumferencemeasures compared with age-matched patients without MS. Despite lowered SSBG level in group 1 patients, it remains within normallimits and therefore can not be used as a diagnostic marker of age-specific hypogonadism and MS. In patients with these conditions, there isno correlation between SSBG and IRI levels; in hypogonadic patients the SSBG level is unrelated to waist measures regardless of the presenceor absence of MS.
About the Authors
Yulia Alexandrovna Tishova
Endocrinological Research Centre, Moscow
Georgy Zhiulievich Mskhalaya
Endocrinological Research Centre, Moscow
Svetlana Yur'evna Kalinchenko
Russian University of People’s Friendship, Moscow
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Review
For citations:
Tishova Yu.A., Mskhalaya G.Zh., Kalinchenko S.Yu. Age-related hypogonadism in men with metabolic syndrome. Diabetes mellitus. 2010;13(1):21-25. (In Russ.) https://doi.org/10.14341/2072-0351-6012
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