New prospects in the treatment of diabetes mellitus
https://doi.org/10.14341/2072-0351-5547
Abstract
Cardiovascular complications, a major cause for disability and morbidity in diabetes mellitus (DM), constitute the greatest threat of the diabetes epidemic. Glycemic stability within the therapeutic targets is a prerequisite to prevention of micro- and macrovascular complications of DM. Traditional therapies are aimed at cardinal defects determining development of type 2 diabetes mellitus (T2DM). Unfortunately even in combination they fail to deliver long-term glycemic control without stimulation of weight gain and increase in hypoglycemic risks with negative cardial, renal and hepatic impact. Preservation of beta-cell secretion capacity is also hardly attainable. Incretin-based therapy is a novel, actively developed approach that influences gut hormone physiology for better glycemic control. So far research efforts have yielded two classes of drugs: GLP-1 mimetics and DPP-4 inhibitors. Both are regarded nowadays for a number of important benefits, including beta-cell function improvement, adjusted to human physiology (i.e. stimulation of insulin secretion ?as needed? by the body, - hence low hypoglycemic risk). They also feature positive cardiovascular and body weight effects, thereby taking an important position in complex DM treatment.
About the Authors
Minara Shamkhalovna Shamkhalova
Endocrinology Research Centre
Russian Federation
Russian Federation
Natalya Petrovna Trubitsyna
Endocrinology Research Centre
Russian Federation
Russian Federation
Marina Vladimirovna Shestakova
Endocrinology Research Centre
Russian Federation
Russian Federation
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Review
For citations:
Shamkhalova M.Sh., Trubitsyna N.P., Shestakova M.V. New prospects in the treatment of diabetes mellitus. Diabetes mellitus. 2012;15(4):109-114. (In Russ.) https://doi.org/10.14341/2072-0351-5547
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