Individual stepwise intensification of insulin analogue therapy in type 2 diabetes mellitus
https://doi.org/10.14341/2072-0351-5544
Abstract
Article reviews basic steps and regimens of insulin analogue therapy intensification in patients with type 2 diabetes mellitus (T2DM). Intensification of insulin therapy is commonly implemented by supplementation of basal insulin with prandial before breakfast, lunch and dinner. Updated EASD/ADA guidelines (August 2012) recommend individual stepwise intensification of T2DM insulin therapy. Application of insulin analogues simplifies diabetes training and patient self-monitoring.
About the Authors
Alexander Sergeevich Ametov
Russian medical academy of postdegree education
Russian Federation
Russian Federation
Natalya Al'bertovna Chernikova
Russian medical academy of postdegree education
Russian Federation
Russian Federation
References
1. Ametov AS. Type 2 Diabetes Mellitus. Challenges and decisions . Moscow: GEOTAR-Media; 2011. p. 10-11.
2. Ametov AS. Type 2 Diabetes Mellitus. Challenges and decisions . Moscow: GEOTAR-Media; 2011. p. 254-255.
3. Jabbour S. Primary care physicians andinsulin initiation: multiple barriers, lack of knowledge or both? Int J Clin Pract. 2008 Jun;62(6):845-847.
4. Cryer PE. Hypoglycaemia: the limiting factor in the glycemic management of Type I and Type II diabetes. Diabetologia. 2002 Jul;45(7):937-948. Epub 2002 Apr 26.
5. Holman RR, Farmer AJ, Davies MJ, Levy JC, Darbyshire JL, Keenan JF, Paul SK; 4-T Study Group. Three-year efficacy of complex insulin regimens in type 2 diabetes. N Engl J Med. 2009 Oct 29;361(18):1736-1747. Epub 2009 Oct 22.
6. Philis-Tsimikas A, Charpentier G, Clauson P, Ravn GM, Roberts VL, Thorsteinsson B. Comparison of once-daily insulin detemir with NPH insulin added to a regimen of oral antidiabetic drugs in poorly controlled type 2 diabetes. Clin Ther. 2006 Oct;28(10):1569-1581.
7. Rosenstock J, Davies M, Home PD, Larsen J, Koenen C, Schernthaner G. A randomised, 52-week, treat-to-target trial comparing insulin detemir with insulin glargine when added to glucose-lowering drugs in insulin-naive people with type 2 diabetes. Diabetologia. 2008 Mar;51(3):408-416. Epub 2008 Jan 16.
8. Dedov I.I., Shestakova M.V., Aleksandrov An.A., Galstyan G.R., Grigoryan O.R., Esayan R.M., Kalashnikov V.Yu., Kuraeva T.L., Lipatov D.V., Mayorov A.Yu., Peterkova V.A., Smirnova O.M., Starostina E.G., Surkova E.V., Sukhareva O.Yu., Tokmakova A.Yu., Shamkhalova M.Sh., Jarek-Martynova I.R. Algoritmy spetsializirovannoi meditsinskoi pomoshchi bol'nym sakharnym diabetom. 5th ed. Diabetes mellitus. 2011;(suppl.1):4-72
9. Heller S, Bode BW, Kozlovski P, Svendsen A. Examing the glycaemic and hypoglycaemic benefits with rapid acting insulin's analogues: a meta-analysis of insulin aspart versus regular human insulin in randomized controlled trials. Diabetologia 2009; 52 (Suppl.1): S359.
10. Inzucchi SE, Bergenstal RM, Buse JB, Diamant M, Ferrannini E, Nauck M, Peters AL, Tsapas A, Wender R, Matthews DR. Management of hyperglycaemia in type 2 diabetes: a patientcentered approach. Position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetologia. 2012 Jun;55(6):1577- 1596. Epub 2012 Apr 20.
11. Meneghini L, Mersebach H, Kumar S, Svendsen AL, Hermansen K. Comparison of 2 intensification regimens with rapid-acting insulin aspart in type 2 diabetes mellitus inadequately controlled by once-daily insulin detemir and oral antidiabetes drugs: the step-wise randomized study. Endocr Pract. 2011 Sep- Oct;17(5):727-736.
12. Milek K, Wizemann E, Martin S, Bohme K, Rendschmid T. Near normoglycaemic control under supplementary insulin therapy in type 2 diabetes with insulin aspart and insulin detemir - is a fixed dose regimen as effective as a flexible therapy regimen? Diabetologia. 2007; 50(Suppl.1):S412.
Review
For citations:
Ametov A.S., Chernikova N.A. Individual stepwise intensification of insulin analogue therapy in type 2 diabetes mellitus. Diabetes mellitus. 2012;15(4):89-94. (In Russ.) https://doi.org/10.14341/2072-0351-5544
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