Vasculogenesis and angiogenesis in diabetes mellitus: novel pathogenetic concepts for treatment of vascular complications
https://doi.org/10.14341/2072-0351-5533
Abstract
Hyperglycemia along with other metabolic disorders may disrupt the balance of pro- and antiangiogenic regulators, thus leading to a maladaptive formation of new blood vessels in the state of diabetes mellitus (DM). In their turn, aberrant angiogenesis and vasculogenesis are important mechanisms of vascular complications in DM. Activation of retinal angiogenesis is a cornerstone of proliferative diabetic retinopathy, though in diabetic nephropathy excessive angiogenesis is only seen at early stages. Quite on the contrary, macrovascular complications are characterized by certain inhibition of both angiogenesis and vasculogenesis. Novel therapeutic approaches, based on correction of angiogenesis, have emerged recently. Clinical trials have shown efficacy of angiogenesis inhibitors (the ?anti-VEGF? agents) for management of diabetic macular edema and proliferative retinopathy. Experimental evidence also indicates that this treatment may hinder the progress of diabetic nephropathy. In addition, stimulation of angiogenesis and vasculogenesis with stem cells or growth factors promise an option for treatment of large vessels in DM.
About the Authors
Vladimir Iosifovich Konenkov
Research Institute of Clinical and Experimental Lymphology
Russian Federation
Russian Federation
Vadim Valer'evich Klimontov
Research Institute of Clinical and Experimental Lymphology
Russian Federation
Russian Federation
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For citations:
Konenkov V.I., Klimontov V.V. Vasculogenesis and angiogenesis in diabetes mellitus: novel pathogenetic concepts for treatment of vascular complications. Diabetes mellitus. 2012;15(4):17-27. (In Russ.) https://doi.org/10.14341/2072-0351-5533
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