Intracellular metabolism of neutrophils and risk for development of type 2 diabetes mellitus in patients with metabolic syndrome
https://doi.org/10.14341/2072-0351-5512
Abstract
77 male patients (mean age 47?7.4 years) without ischaemic heart disease were tested for metabolic syndrome factors, risk for developmentof type 2 diabetes mellitus (T2DM) according to FINDRISK questionnaire, following with assessment of intracellularmetabolism parameters of neutrophils. Increased risk for T2DM positively correlated in these patients with myeloperoxidase activity,level of hydrogen peroxide within neutrophils and BMI. We observed elevation of oxygen-dependent metabolism in neutrophils formpatients with morbid obesity, accompanied with decrease in antioxidant factors, which is suggestive of oxidative stress.
About the Authors
Andrey Evgen'evich Kratnov
Yaroslavl State Medical Academy, Yaroslavl
Elena Nikolaevna Lopatnikova
Yaroslavl State Medical Academy, Yaroslavl
Alexander Andreevich Kratnov
Yaroslavl State Medical Academy, Yaroslavl
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Review
For citations:
Kratnov A.E., Lopatnikova E.N., Kratnov A.A. Intracellular metabolism of neutrophils and risk for development of type 2 diabetes mellitus in patients with metabolic syndrome. Diabetes mellitus. 2012;15(2):13-16. (In Russ.) https://doi.org/10.14341/2072-0351-5512
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