Insulin pump therapy of type 1 diabetes mellitus in children and adolescents in the Moscow region

Aim.
To assess dynamics of glycated hemoglobin levels and insulin doses per kg bw in children and adolescents with poorly controlled type 1 diabetes mellitus using insulin pumps.
Materials and methods.
Retrospective analysis of HbA_1c levels and insulin doses per kg bw in children aged 2-17 years with DM1 (mean duration 5.3?3.1) before and 18 months after onset of insulin pump therapy (Medtronic Minimed 712 and 722) with a short-acting insulin analog Novopramid (Novo Nordisk) or Humalog (Ely Lilly) given to 55 (52,4%) and 50 (47,6%) of the patients respectively. НbА1с level and mean daily insulin dose per kg bw were determined when a patient visited the doctors office every 3 months.
Results.
Insulin pump therapy in patients with initially poorly controlled DM1 resulted in a decrease of HbA_1c from 9.8?0.8 to 7,8?0,5% within 18 months after its beginning (p<0,05) in the absence of severe hypoglycemia and ketoacidosis requiring hospitalization. Simultaneously, mean daily insulin requirement reduced especially in patients aged 15-18 yr (p<0,05). None of the patients wished to discontinue insulin pump therapy during the study and after its completion.
Conclusion.
Insulin pump therapy is an efficacious tool for the improvement of metabolic control in children and adolescents with poorly compensated CD1 regardless of age and duration of the disease.

type 1 diabetes mellitus, children and adolescents, insulin pump therapy, glycated hemoglobin, insulin requirement, efficiency of therapy