Rationale for the concept of combined initial therapy im type 2 diabetes mellitus
https://doi.org/10.14341/DM13484
Abstract
Glycemic targets remain a challenge for most patients with type 2 diabetes (T2D). In many cases, this is due to the patient’s non-compliance with the treatment regimen, insufficient self-monitoring, and delayed intensification of therapy. However, these challenges have been present for many years, and even new classes of antidiabetic drugs have not significantly changed the proportion of individuals with optimal target glycated hemoglobin levels of < 7%. Usually the treatment strategy in T2D patients requires gradual intensification from monotherapy to combination therapy, and afterwards to insulin. However, despite the high proportion of patients who do not achieve target glycemic levels, most patients receive only one medication for the first 5-8 years of treatment. Therefore, there is a need to start T2D therapy with combination of drugs instead of monotherapy. This article provides a rationale for this transition and suggests strategies for implementing it.
About the Author
E. A. Shestakova
Russian Medical Academy of Continuous Professional Education; Endocrinology Research Centre
Russian Federation
Competing Interests:
Russian Federation
Ekaterina A. Shestakova, MD, PhD, Associate Professor, сhief research associate
Moscow
Competing Interests:
none
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Shestakova E.A. Rationale for the concept of combined initial therapy im type 2 diabetes mellitus. Diabetes mellitus. 2026;29(3):290-295. (In Russ.) https://doi.org/10.14341/DM13484
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