Structurall features of the pancreas in patients with type 1 diabetes mellitus
https://doi.org/10.14341/DM12892
Abstract
BACKGROUND: Observation of changes in the volume and size of the pancreas has a long history, however, the results of studies are still not unambiguous, the specific causes of changes in pancreatic volume, as well as their consequences, are not clear. According to some data, the decrease of pancreas volume in life expectancy is 35–45% in the population of patients with a long history of type 1 diabetes, and about 20–25% during the first year of the disease. Interestingly, in T1D in 20–45% of cases, the development of exocrine pancreatic insufficiency is noted, one of the manifestations of which is pancreatic atrophy, leading to a decrease in life expectancy.
AIM: Assess the volume and size of the pancreas, as well as factors that can influence on their changes.
MATERIALS AND METHODS: The study included 78 patients with type 1 diabetes mellitus, the control group consisted of 23 people without previously identified disorders of carbohydrate metabolism, comparable in age and anthropometric parameters with the study group. RESULTS: The volume and dimensions of the pancreas were statistically significantly less in patients with T1D than in the control group. In addition, the influence of the duration of T1D and the age of onset of the disease on these indicators has been proven.
CONCLUSION: The volume and size of the pancreas in patients with T1D is less than in healthy individuals. It is necessary to study the effect of these changes on the function of the pancreas.
Supporting agencies: Grant of Russian Science Foundation № 17-75-30035
About the Authors
M. R. Ragimov
Endocrinology Research Centre
Russian Federation
Russian Federation
Magomedkerim R. Ragimov, MD, PhD, student
11 Dm. Ulyanova street, 117036 Moscow
eLibrary SPIN: 8445-6795
T. V. Nikonova
Endocrinology Research Centre
Russian Federation
Russian Federation
Tatiana V. Nikonova, MD, PhD
Moscow
eLibrary SPIN: 8863-0201
D. M. Babaeva
Endocrinology Research Centre
Russian Federation
Russian Federation
Diana M. Babaeva, MD
Moscow
eLibrary SPIN: 6431-9855
V. P. Vladimirova
Endocrinology Research Centre
Russian Federation
Russian Federation
Victoria P. Vladimirova, MD, PhD
Moscow
eLibrary SPIN: 9830-3276
M. V. Shestakova
Endocrinology Research Centre
Russian Federation
Russian Federation
Marina V. Shestakova, MD, PhD, Professor
Moscow
eLibrary SPIN: 7584-7015
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Supplementary files
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1. Рисунок 1. Пациент, 19 лет (длительность СД1 — 17 лет). МРТ органов брюшной полости на уровне головки поджелудочной железы (А, В) и на уровне тела и хвоста (Б, Г). А, Б — Т2-ВИ, аксиальная плоскость; В, Г — Т1-ВИ, аксиальная плоскость. Определяется диффузное снижение объема поджелудочной железы, более выражены изменения на уровне головки (стрелки). ОПЖ=15,2 мл; ОПЖ/ИМТ=15,2/22,98=0,66 мл/(кг/м2); ОПЖ/ППТ=15,2/1,89=8,04 мл/м2. Примечание. ОПЖ — объем поджелудочной железы. ИМТ — индекс массы тела. ППТ — площадь поверхности тела. ВИ — взвешенные изображения. | |
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2. Рисунок 2. Здоровый доброволец из группы контроля, 25 лет, без нарушений углеводного обмена. МРТ органов брюшной полости на уровне головки поджелудочной железы (А) и на уровне тела и хвоста (Б) (поджелудочная железа показана стрелками). А и Б — Т1-ВИ, аксиальная плоскость. ОПЖ=57,3 мл; ОПЖ/ИМТ=57,3/24,3=2,36 мл/(кг/м2); ОПЖ/ППТ=57,3/1,98=28,93 мл/м2. Примечание. ОПЖ - объем поджелудочной железы. ИМТ - индекс массы тела. ППТ - площадь поверхности тела. ВИ - взвешенные изображения. | |
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3. Рисунок 3. Пациент, 24 года (длительность СД1 4 года). МРТ органов брюшной полости на уровне головки поджелудочной железы (А, В) и на уровне тела и хвоста (Б, Г). А, Б — Т2-ВИ, аксиальная плоскость; В, Г — Т1-ВИ, аксиальная плоскость. Определяется диффузное снижение объема поджелудочной железы, больше изменения выражены на уровне головки (стрелки). ОПЖ=38,1 мл; ОПЖ/ИМТ=38,1/23,4=1,63 мл/(кг/м2); ОПЖ/ППТ=38,1/1,94=19,64 мл/м2. Примечание. ОПЖ — объем поджелудочной железы. ИМТ — индекс массы тела. ППТ — площадь поверхности тела. ВИ — взвешенные изображения. | |
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For citations:
Ragimov M.R., Nikonova T.V., Babaeva D.M., Vladimirova V.P., Shestakova M.V. Structurall features of the pancreas in patients with type 1 diabetes mellitus. Diabetes mellitus. 2022;25(3):239-248. (In Russ.) https://doi.org/10.14341/DM12892
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