COVID-19 and kidneys

M. S. Shamkhalova; N. G. Mokrysheva; M. V. Shestakova

doi:10.14341/DM12506

COVID-19 and kidneys

M. S. Shamkhalova, N. G. Mokrysheva, M. V. Shestakova

https://doi.org/10.14341/DM12506

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Abstract

COVID-19 poses a real threat to patients with comorbid conditions such as diabetes mellitus (DM), hypertension, cardiovascular, renal or hepatic disorders. Kidney damage is very likely in people with diabetes who have undergone a new infection, and the risk of developing acute renal injury is associated with mortality. Potential mechanisms of kidney involvement in the clinical picture of the disease may include cytokine damage, cross-organ damage, and systemic effects that determine the treatment strategy. These mechanisms are closely interrelated and are important for individuals on extracorporeal therapy and kidney transplants. Autopsy data provide evidence of SARS-CoV-2 virus invasion into kidney tissue with damage to tubular epithelium cells and podocytes, and red blood cell aggregation in severely COVID-19 patients. By including individuals with chronic kidney disease in planned COVID-19 research protocols, an evidence base for effective and safe treatments can be generated.

Keywords

COVID-19, diabetes mellitus, acute kidney injury, dialysis, kidney transplant

About the Authors

M. S. Shamkhalova

Endocrinology Research Centre
Russian Federation

MD, PhD

N. G. Mokrysheva

Endocrinology Research Centre
Russian Federation

MD, PhD, Professor

M. V. Shestakova

Endocrinology Research Centre
Russian Federation

MD, PhD, Professor

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Supplementary files

	1. Fig. 1. Proximal tubules with vacuole degeneration (arrows) (a), aggregates of red blood cells in peritubular capillaries (arrowheads) (b). Post-mortem histological examination of a patient with COVID-19 (light microscopy).
	Subject
	Type	Other
	View (433KB)	Indexing metadata ▾

	2. Fig. 2. coronavirus Particles (red arrows) with characteristic spines (green arrows) in the cytoplasm of the proximal tubules (a) and podocytes (b). Post-mortem histological examination of a patient with COVID-19 (electron microscopy).
	Subject
	Type	Other
	View (353KB)	Indexing metadata ▾

	3. Fig. 3. Nuclear protein SARS-CoV in the tubal epithelium. Post-mortem histological examination of a patient with COVID-19 (immunofluorescence analysis).
	Subject
	Type	Other
	View (172KB)	Indexing metadata ▾

Review

For citations:

Shamkhalova M.S., Mokrysheva N.G., Shestakova M.V. COVID-19 and kidneys. Diabetes mellitus. 2020;23(3):235-241. (In Russ.) https://doi.org/10.14341/DM12506

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND 4.0).

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	Title	Fig. 1. Proximal tubules with vacuole degeneration (arrows) (a), aggregates of red blood cells in peritubular capillaries (arrowheads) (b). Post-mortem histological examination of a patient with COVID-19 (light microscopy).
	Date	2020-08-09
Digital Object Identifier	https://doi.org/10.14341/DM12506-5668

	Title	Fig. 2. coronavirus Particles (red arrows) with characteristic spines (green arrows) in the cytoplasm of the proximal tubules (a) and podocytes (b). Post-mortem histological examination of a patient with COVID-19 (electron microscopy).
	Date	2020-08-09
Digital Object Identifier	https://doi.org/10.14341/DM12506-5669

	Title	Fig. 3. Nuclear protein SARS-CoV in the tubal epithelium. Post-mortem histological examination of a patient with COVID-19 (immunofluorescence analysis).
	Date	2020-08-09
Digital Object Identifier	https://doi.org/10.14341/DM12506-5670

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Diabetes mellitus

COVID-19 and kidneys

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Abstract

Keywords

About the Authors

References

Supplementary files

Review

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