The role of the gut microbiota in the development of type 1 diabetes mellitus
L. I. Ibragimova,
E. A. Kolpakova,
A. V. Dzagakhova,
L. V. Egshatyan,
E. V. Pokrovskaya,
O. S. Derevyanko,
T. V. Nikonova https://doi.org/10.14341/DM10326
Abstract
At the beginning of the XXI century, with the advent of technical capabilities and new methods of genes sequencing, the attention of researchers to the study of the human metagenome has significantly increased. The interaction between changes in the qualitative and quantitative composition of the gut microbiota (GM) and various diseases is being actively studied, a search for specific metabolites and genes of microorganisms that may be associated with the development, in particular, of immune-mediated diseases is underway. In recent years, a lot of new data have been published on the possible contribution of gut flora dysbiosis to the development of Type 1 Diabetes Mellitus (T1DM), while the first assumptions were put forward as far back as 1970s. The search for pathogenetic mechanisms of GM influence on the development and progression of T1DM is becoming an increasingly relevant objective, since in recent years the incidence of T1DM is rapidly increasing, which is a serious health problem throughout the world.
This review discusses the current ideas about the role of GM in the immunopathogenesis of T1DM, new data on the near-term prospects in the study of the human macrogenome, current ideas about the role of GM in the immunopathogenesis of T1DM, and the possibility of applying this knowledge by the practitioner.
About the Authors
L. I. Ibragimova
Endocrinology Research Centre
Russian Federation
Russian Federation
Liudmila I. Ibragimova, MD, PhD; eLibrary SPIN: 5013-8222
11, Dm. Ulyanova street, 117036 Moscow
E. A. Kolpakova
Endocrinology Research Centre
Russian Federation
Russian Federation
Evgenia A. Kolpakova, MD, PhD student; eLibrary SPIN: 5040-8628
Moscow
A. V. Dzagakhova
Endocrinology Research Centre
Russian Federation
Russian Federation
Agunda V. Dzagakhova, clinical resident
Moscow
L. V. Egshatyan
Moscow Clinical Research Center A.S. Loginova; A.I. Yevdokimov Moscow State University of Medicine and Dentistry
Russian Federation
Russian Federation
Lilit V. Egshatyan, MD, PhD; eLibrary SPIN: 4552-5340
Moscow
E. V. Pokrovskaya
Endocrinology Research Centre
Russian Federation
Russian Federation
Elena V. Pokrovskaya; eLibrary SPIN: 8769-5010
Moscow
O. S. Derevyanko
Ltd “DFC – West”
Russian Federation
Russian Federation
Olga S. Derevyanko, MD, PhD; eLibrary SPIN: 9977-7856
Moscow
T. V. Nikonova
Endocrinology Research Centre
Russian Federation
Russian Federation
Tatiana V. Nikonova, MD, PhD; eLibrary SPIN: 8863-0201
Moscow
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For citations:
Ibragimova L.I., Kolpakova E.A., Dzagakhova A.V., Egshatyan L.V., Pokrovskaya E.V., Derevyanko O.S., Nikonova T.V. The role of the gut microbiota in the development of type 1 diabetes mellitus. Diabetes mellitus. 2021;24(1):62-69. (In Russ.) https://doi.org/10.14341/DM10326
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