The role of the gut microbiota in the development of type 1 diabetes mellitus
L. I. Ibragimova,
E. A. Kolpakova,
A. V. Dzagakhova,
L. V. Egshatyan,
E. V. Pokrovskaya,
O. S. Derevyanko,
T. V. Nikonova https://doi.org/10.14341/DM10326
Abstract
At the beginning of the XXI century, with the advent of technical capabilities and new methods of genes sequencing, the attention of researchers to the study of the human metagenome has significantly increased. The interaction between changes in the qualitative and quantitative composition of the gut microbiota (GM) and various diseases is being actively studied, a search for specific metabolites and genes of microorganisms that may be associated with the development, in particular, of immune-mediated diseases is underway. In recent years, a lot of new data have been published on the possible contribution of gut flora dysbiosis to the development of Type 1 Diabetes Mellitus (T1DM), while the first assumptions were put forward as far back as 1970s. The search for pathogenetic mechanisms of GM influence on the development and progression of T1DM is becoming an increasingly relevant objective, since in recent years the incidence of T1DM is rapidly increasing, which is a serious health problem throughout the world.
This review discusses the current ideas about the role of GM in the immunopathogenesis of T1DM, new data on the near-term prospects in the study of the human macrogenome, current ideas about the role of GM in the immunopathogenesis of T1DM, and the possibility of applying this knowledge by the practitioner.
About the Authors
L. I. Ibragimova
Endocrinology Research Centre
Russian Federation
Russian Federation
Liudmila I. Ibragimova, MD, PhD; eLibrary SPIN: 5013-8222
11, Dm. Ulyanova street, 117036 Moscow
E. A. Kolpakova
Endocrinology Research Centre
Russian Federation
Russian Federation
Evgenia A. Kolpakova, MD, PhD student; eLibrary SPIN: 5040-8628
Moscow
A. V. Dzagakhova
Endocrinology Research Centre
Russian Federation
Russian Federation
Agunda V. Dzagakhova, clinical resident
Moscow
L. V. Egshatyan
Moscow Clinical Research Center A.S. Loginova; A.I. Yevdokimov Moscow State University of Medicine and Dentistry
Russian Federation
Russian Federation
Lilit V. Egshatyan, MD, PhD; eLibrary SPIN: 4552-5340
Moscow
E. V. Pokrovskaya
Endocrinology Research Centre
Russian Federation
Russian Federation
Elena V. Pokrovskaya; eLibrary SPIN: 8769-5010
Moscow
O. S. Derevyanko
Ltd “DFC – West”
Russian Federation
Russian Federation
Olga S. Derevyanko, MD, PhD; eLibrary SPIN: 9977-7856
Moscow
T. V. Nikonova
Endocrinology Research Centre
Russian Federation
Russian Federation
Tatiana V. Nikonova, MD, PhD; eLibrary SPIN: 8863-0201
Moscow
References
1. Mikrobiota. Ed. by Nikonov EL, Popovа EN. Moscow: Media Sfera; 2019. (In Russ.).
2. Afineevskaya AY, Mal’kov OА, Govorukhina AA. The Role of Intestinal Microbiota in the Pathogenesis of Atherosclerosis and Promising Preventive Measures (Review). J Med Biol Res. 2020;8(2):184-193. (In Russ.). https://doi.org/10.37482/2542-1298-Z009
3. Dzgoeva FKh, Egshatyan LV. Intestinal microbiota and type 2 diabetes mellitus. Endocrinology: News, Opinions, Training. 2018;7(3):55-63. (In Russ.). https://doi.org/10.24411/2304-9529-2018-13005
4. Kashtanova DA, Egshatyan LV, Tkachyova ON. The Involvement of Human Gut Microbiota in Chronic Systemic Inflammation. Klinicheskaya mikrobiologiya i antimikrobnaya khimioterapiya. 2015;17(4):310-317. (In Russ.).
5. Bulatova EM, Bogdanova NM, Lobanova EA, Gabrusskaya TV. Kishechnaya mikrobiota: sovremennye predstavleniya. Pediatriya. Zhurnal im. GN Speranskogo. 2009;87(3):104-109. (In Russ.).
6. Moles L, Gómez M, Heilig H, et al. Bacterial Diversity in Meconium of Preterm Neonates and Evolution of Their Fecal Microbiota during the First Month of Life. Sanz Y, ed. PLoS One. 2013;8(6):e66986. https://doi.org/10.1371/journal.pone.0066986
7. Yatsunenko T, Rey FE, Manary MJ, et al. Human gut microbiome viewed across age and geography. Nature. 2012;486(7402):222-227. https://doi.org/10.1038/nature11053
8. Egshatyan LV, Tkacheva ON, Kafarskaya LI, et al. The changes of gut microbiota associated with age and lifestyle. Obe Metab. 2015;12(2):3-9. (In Russ.). https://doi.org/10.14341/omet201523-9
9. Turnbaugh PJ, Ley RE, Hamady M, et al. The Human Microbiome Project. Nature. 2007;449(7164):804-810. https://doi.org/10.1038/nature06244
10. Ardissone AN, de la Cruz DM, Davis-Richardson AG, et al. Meconium Microbiome Analysis Identifies Bacteria Correlated with Premature Birth. PLoS One. 2014;9(3):e90784. https://doi.org/10.1371/journal.pone.0090784
11. O’Toole PW, Claesson MJ. Gut microbiota: Changes throughout the lifespan from infancy to elderly. Int Dairy J. 2010;20(4):281-291. https://doi.org/10.1016/j.idairyj.2009.11.010
12. Hesla HM, Stenius F, Jäderlund L, et al. Impact of lifestyle on the gut microbiota of healthy infants and their mothers — the ALADDIN birth cohort. FEMS Microbiol Ecol. 2014;90(3):791-801. https://doi.org/10.1111/1574-6941.12434
13. Kulikov AV, Shifman EM, Belomestnov SR, Levit AL. Neotlozhnaya pomoshch’ pri preeklampsii i ee oslozhneniyakh. Eklampsiya, HELLP-sindrom. Klinicheskie rekomendatsii. Anesteziologiya i reanimatologiya. 2013;5 (In Russ.).
14. Nikonov EL, Gurevich KG. Mikrobiota razlichnykh lokusov organizma. Moscow: Rossiiskaya akademiya nauk. 2017. (In Russ.).
15. Gülden E, Wong FS, Wen L. The gut microbiota and Type 1 Diabetes. Clin Immunol. 2015;159(2):143-153. https://doi.org/10.1016/j.clim.2015.05.013
16. Mueller NT, Bakacs E, Combellick J, et al. The infant microbiome development: mom matters. Trends Mol Med. 2015;21(2):109-117. https://doi.org/10.1016/j.molmed.2014.12.002
17. Garrido D, Ruiz-Moyano S, Mills DA. Release and utilization of N-acetyl-d-glucosamine from human milk oligosaccharides by Bifidobacterium longum subsp. infantis. Anaerobe. 2012;18(4):430-435. https://doi.org/10.1016/j.anaerobe.2012.04.012
18. Fallani M, Young D, Scott J, et al. Intestinal Microbiota of 6-week-old Infants Across Europe: Geographic Influence Beyond Delivery Mode, Breast-feeding, and Antibiotics. J Pediatr Gastroenterol Nutr. 2010;51(1):77-84. https://doi.org/10.1097/MPG.0b013e3181d1b11e
19. Siljander H, Honkanen J, Knip M. Microbiome and type 1 diabetes. EBioMedicine. 2019;46:512-521. https://doi.org/10.1016/j.ebiom.2019.06.031
20. Han H, Li Y, Fang J, et al. Gut Microbiota and Type 1 Diabetes. Int J Mol Sci. 2018;19(4):995. https://doi.org/10.3390/ijms19040995
21. Durazzo M, Ferro A, Gruden G. Gastrointestinal Microbiota and Type 1 Diabetes Mellitus: The State of Art. J Clin Med. 2019;8(11):1843. https://doi.org/10.3390/jcm8111843
22. Alekseeva AE, Brusnigina NF. Possibility and perspectives of massive parallel sequencing methods application in the diagnostics and epidemiological surveillance of infection diseases. Zhurnal MediAl’. 2014;2(12):6-28. (In Russ.).
23. Knip M, Siljander H. The role of the intestinal microbiota in type 1 diabetes mellitus. Nat Rev Endocrinol. 2016;12(3):154-167. https://doi.org/10.1038/nrendo.2015.218
24. Ilonen J, Lempainen J, Veijola R. The heterogeneous pathogenesis of type 1 diabetes mellitus. Nat Rev Endocrinol. 2019;15(11):635-650. https://doi.org/10.1038/s41574-019-0254-y
25. Costa FRC, Françozo MCS, de Oliveira GG, et al. Gut microbiota translocation to the pancreatic lymph nodes triggers NOD2 activation and contributes to T1D onset. J Exp Med. 2016. https://doi.org/10.1084/jem.20150744
26. Macfarlane S, Macfarlane GT. Regulation of short-chain fatty acid production. Proc Nutr Soc. 2003;62(1):67-72. https://doi.org/10.1079/PNS2002207
27. Paparo L, di Costanzo M, di Scala C, et al. The Influence of Early Life Nutrition on Epigenetic Regulatory Mechanisms of the Immune System. Nutrients. 2014;6(11):4706-4719. https://doi.org/10.3390/nu6114706
28. Gibson GR, Roberfroid MB. Dietary Modulation of the Human Colonic Microbiota: Introducing the Concept of Prebiotics. J Nutr. 1995;125(6):1401-1412. https://doi.org/10.1093/jn/125.6.1401
29. Ardatskaya MD, Stolyarova LG, Arkhipova EV, Filimonova OYu. Metabiotics as a natural development of a probiotic concept. Trudnyi patsient. 2017;15(6-7). (In Russ.).
30. Cai T, Ye X, Yong H, et al. Fecal microbiota transplantation relieve painful diabetic neuropathy. Medicine (Baltimore). 2018;97(50):e13543. https://doi.org/10.1097/MD.0000000000013543
31. Lübbert C, Salzberger B, Mössner J. Fäkaler Mikrobiomtransfer. Internist (Berl). 2017;58(5):456-468. https://doi.org/10.1007/s00108-017-0203-6
32. Klinicheskaya patofiziologiya. Ed. by Chereshnev VA, Litvitsky P.F., Tsygan VN. Moscow: Litres; 2018. (In Russ.).
Supplementary files
Review
For citations:
Ibragimova L.I., Kolpakova E.A., Dzagakhova A.V., Egshatyan L.V., Pokrovskaya E.V., Derevyanko O.S., Nikonova T.V. The role of the gut microbiota in the development of type 1 diabetes mellitus. Diabetes mellitus. 2021;24(1):62-69. (In Russ.) https://doi.org/10.14341/DM10326
Views:
6551
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND 4.0).
Email this article 
