15-year risk of developing type 2 diabetes mellitus and its relationship with personal anxiety, sleep disturbance among men 45-69 years old in Russia /Siberia (international epidemiological study “HAPIEE”)

BACKGROUND: Determine the effect of personal anxiety, sleep disorders on the 15-year risk of developing (RR) diabetes mellitus (DM) type 2 among men (M) 45-69 years in Russia / Siberia (Novosibirsk).

METHODS: In 2003–2005 As part of the IV screening of the international epidemiological study “HAPIEE”, a representative sample of m 45–69 years was examined (n=781 M, mean age-56.48±0.20 years, response – 61.00%). The level of personal anxiety (PA) was assessed using the Spielberger scale (HPA – high, MPA – medium, LPA – low). With the help of the scale “Knowledge and attitude to one’s health”, the level of sleep disorders (SD) was assessed. The period of observation of the cohort was 15 years. To check the statistical significance of the differences between the groups, the Pearson χ² test was used. For risk assessment, Cox-regression single-factor and multivariate regression proportional hazards model was used (Cox-­regression).

RESULTS: Among persons with the first occurrence of DM type 2, HPA at the screening was 59.50%, and 63.30% had SD. The combination of HPA and SD was significant among M with the first-onset diabetes mellitus. During the 15-year period, among M with HLA, the risk of developing type 2 diabetes was 1.60 times higher than without. Among people with SD, the risk of developing type 2 diabetes was 2.40 times higher than without. In Cox – the proportional multifactor model, each variable had its own independent influence. HPA increased the RR DM of the 2nd type by 1.90 times, and SD – by 2.80 times.

CONCLUSION: It was established that a high level of PA and SD are independent predictors of type 2 diabetes, moreover, with SD, the risk of developing type 2 diabetes is higher than with a high level of PA.

diabetes mellitus, anxiety traits, sleep disturbances, population, males, hazard ratio

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