Nonalcoholic fatty liver disease: cause or consequence of insulin resistance?
Ekaterina E. Mishina,
Alexander Y. Mayorov,
Pavel O. Bogomolov,
Maria V. Matsievich,
Ksenia Y. Kokina,
Apollinariya V. Bogolyubova 
Abstract
Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) are pathological conditions that are co-occurring, and have been reaching epidemic proportions. One of the most significant risk factors for the development of both T2DM and NAFLD is obesity, which increases existing insulin resistance (IR). IR thought to be one of the main pathogenic causes linking T2DM and NAFLD. In recent years, there has been increased interest in obtaining non-invasive methods for assessing fibrosis and determining indications for liver biopsy, such as the NAFLD fibrosis score, extended liver fibrosis panel, and transient elastography. However, liver biopsy remains the gold standard for diagnosing NAFLD. Given that patients with T2DM are at higher risk of NAFLD than the general population, and that the presence of diabetes is a risk factor for the progression of NAFLD, patients with T2DM should be more closely monitored by clinicians. The present review paper is devoted to the search for cause–effect relationships of concurrent diseases such as NAFLD and disorders of carbohydrate metabolism, and priority areas of diagnosis of NAFLD.
About the Authors
Ekaterina E. MishinaEndocrinology Research Centre
Russian Federation
MD, PhD student
Competing Interests:
No conflict of interests
Alexander Y. Mayorov
Endocrinology Research Centre
Russian Federation
MD, PhD
Competing Interests:
No conflict of interests
Pavel O. Bogomolov
Moscow Area Moscows regional research clinical institute n.a. M.F. Vladimirskiy
Russian Federation
MD, PhD
Competing Interests:
No conflict of interests
Maria V. Matsievich
Moscow Area Moscows regional research clinical institute n.a. M.F. Vladimirskiy
Russian Federation
MD, PhD
Competing Interests:
No conflict of interests
Ksenia Y. Kokina
Moscow Area Moscows regional research clinical institute n.a. M.F. Vladimirskiy
Russian Federation
MD
Competing Interests:
No conflict of interests
Apollinariya V. Bogolyubova
Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences
Russian Federation
junior staff scientist
Competing Interests:
No conflict of interests
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Supplementary files
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1. Рис. 1. Гистологические варианты НАЖБП (адаптировано [14]). | |
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2. Рис. 2. Теория «множественных ударов» (адаптировано [19]). | |
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3. Рис. 3. Эффекты гепатокинов (адаптировано [31]). | |
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Review
For citations:
Mishina E.E., Mayorov A.Y., Bogomolov P.O., Matsievich M.V., Kokina K.Y., Bogolyubova A.V. Nonalcoholic fatty liver disease: cause or consequence of insulin resistance? Diabetes mellitus. 2017;20(5):335-343. (In Russ.)
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