Изучение количества циркулирующих прогениторных клеток эндотелия у больных сахарным диабетом 1 типа
Abstract
Aim.
Circulating progenitor endothelial cells (CPCs) play an important role in the regeneration of damaged vascular endothelium. We aimed to study the effect of type 1 diabetes mellitus (DM) on the number of different lines of CPCs.
Methods.
The number of different lines of CPCs was evaluated by flow cytometry in 45 patients with type 1 DM (mean age: 26,6±6,5 years) of different duration and 14 healthy volunteers.
Results.
The number of CPCs in the peripheral blood flow of patients with type 1 DM was significanlty reduced compared with that in healthy volunteers and had a reliable inverse correlation with glycated haemoglobin (HbA1c).
Conclusions.
The number of CPCs in the peripheral blood flow of patients with type 1 DM depended on the level of DM compensation. Of the different lines of CPCs, Lin-CD34+ cells were significantly reduced by 42% (p=0,006), Lin-CD34+c-Kit- cells by 42% (p=0,007) and Lin-CD34+c-Kit+ cells by 41% (p=0,022). Thus, the number of CPCs in the peripheral blood of patients with type 1 DM is reduced with higher levels of HbA1c.
About the Authors
Angelina Valerievna Sokolova
Endocrinological Research Centre
Russian Federation
Russian Federation
MD, Research fellow, Institute of Diabetes, Endocrinology Research Centre
Tatyana Nikolaevna Kochegura
Lomonosov Moscow State University
Russian Federation
Russian Federation
MD, PhD, Medical Educational Scientific Centre, Lomonosov Moscow State University
Elena Viktorovna Parfyonova
Russian Cardiological Research and Production Complex
Russian Federation
Russian Federation
MD, PhD, Professor, Russian Cardiology Research and Production Comple
Marina Vladimirovna Shestakova
Endocrinological Research Centre; Sechenov First Moscow State Medical University
Russian Federation
Russian Federation
MD, PhD, Professor, Corresponding member of Russian academy of sciences, Director of Diabetes Institute, Endocrinology Research Centre; Head of Department of Endocrinology and Diabetology, Pediatric Faculty, I.M.Sechenov First Moscow State Medical University
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Supplementary files
Review
For citations:
Sokolova A.V., Kochegura T.N., Parfyonova E.V., Shestakova M.V. . Diabetes mellitus. 2015;18(3):51-56.
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