Metformin effects to carbohydrate and lipids metabolism in impaired glucose tolerance patients.
Abstract
Aim of this study was to investigate the effect metformin to carbohydrate, lipids metabolism and leptin level in impaired glucose tolerance (IGT)patients.Methods.
16 patients with IGT were studied. Age of participant was 55.1?8.2 yrs. All patients was divide into two groups: treatment group (bagomet1700 a day and diet) and control group (only diet). Effect of therapy was access in HbA1c, fasting glucose (FG), HOMA, lipids, liver glucose production(LGP) and leptin, which investigate in intravenous glucose tolerance test (IVGTT).
Results.
Normalization of carbohydrate metabolism was discover in 37.5% in treatment group and in 12.5% in control group. HbA1c was decreasefrom 6.4 to 5.9 % (р<0.05), LGP was decrease from 4.6?1.3 mmol/l to 3.0 ?1.7 mmol/l and HOMA also was decrease in treatment group. We foundout significant decrease low-density lipoprotein and triglyceride levels in treatment group. We didnt find a change leptin level in treatment group.
Conclusion.
The therapy of bagomet leads to normalization of carbohydrate metabolism in 37.5% persons with IGT.
16 patients with IGT were studied. Age of participant was 55.1?8.2 yrs. All patients was divide into two groups: treatment group (bagomet1700 a day and diet) and control group (only diet). Effect of therapy was access in HbA1c, fasting glucose (FG), HOMA, lipids, liver glucose production(LGP) and leptin, which investigate in intravenous glucose tolerance test (IVGTT).
Results.
Normalization of carbohydrate metabolism was discover in 37.5% in treatment group and in 12.5% in control group. HbA1c was decreasefrom 6.4 to 5.9 % (р<0.05), LGP was decrease from 4.6?1.3 mmol/l to 3.0 ?1.7 mmol/l and HOMA also was decrease in treatment group. We foundout significant decrease low-density lipoprotein and triglyceride levels in treatment group. We didnt find a change leptin level in treatment group.
Conclusion.
The therapy of bagomet leads to normalization of carbohydrate metabolism in 37.5% persons with IGT.
About the Authors
Alexander Vasil'evich Dreval'
M.F. Vladimirsky Moscow Regional Research Clinical Institute, Moscow
Inna Vladimirovna Misnikova
M.F. Vladimirsky Moscow Regional Research Clinical Institute, Moscow
Irina Vladimirovna Trigolosova
M.F. Vladimirsky Moscow Regional Research Clinical Institute, Moscow
Raisa Stepanovna Tishenina
M.F. Vladimirsky Moscow Regional Research Clinical Institute, Moscow
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Review
For citations:
Dreval' A.V., Misnikova I.V., Trigolosova I.V., Tishenina R.S. Metformin effects to carbohydrate and lipids metabolism in impaired glucose tolerance patients. Diabetes mellitus. 2010;13(2):63-67. (In Russ.)
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