Combination of active stage of diabetic Charcot neuroosteoarthropathy and diabetic lower limb macroangiopathy
Abstract
Combination of active stage of diabetic Charcot neuroosteoarthropathy and diabetic lower limb macroangiopathy is the rare condition. In the present paper we describe two cases of development of acute Charcot foot in the non-critically ischemic foot. The first case is the patient with previously diagnosed intermitted claudication and the second case is patient who developed the Charcot foot 5 months later after successful endovascular treatment of arterial occlusions of his left lower limb. In both cases the absence of redness in the early stage, the mild-to-moderate pain and mild temperature gradient between affected and non-affected feet were noticed. The clinical course of the Charcot disease in the first patient was favourable. He used walker for 9 months and his foot shape was preserved and deformity was considered as mild. The second patient had more active and profound destructions due to delay of the treatment. He was casted, however his deformity progressed and the treatment continues up to date. In both patients the MRI revealed more affected bones compared with X-ray. These cases emphasize the importance of keeping in mind the Charcot disease even in patients with diabetic peripheral vascular disease.
About the Authors
Anastasia G. DeminaRussian Federation
endocrinologist-podiatrist
Vadim B. Bregovskiy
Russian Federation
PhD, endocrinologist-podiatrist
Irina A. Karpova
Russian Federation
PhD, Chief of the Saint-Petersburg City Diabetes Centre
References
1. Rogers L, Frykberg R, Armstrong D, et al. The Charcot foot in diabetes. Diabetes Care. 2011;34(9):2123−2129. doi: https://doi.org/10.2337/dc11-0844
2. Wukich DK, Raspovic KM, Suder NC. Prevalence of peripheral arterial disease in patients with diabetic Charcot neuroarthropathy. J Foot Ankle Surg. 2016;55(4):727–731. doi: https://doi.org/10.1053/j.jfas.2016.01.051
3. Jeffcoate W. Vascular calcification and osteolysis in diabetic neuropathy — is RANK-L the missing link? Diabetologia. 2004;47(9):1488–1492. doi: https://doi.org/10.1007/s00125-004-1477-5
4. Ярославцева M.В., Ульянова И.Н., Галстян Г.Р. Система остеопротегерин (OPG)-лиганд рецептора-активатора ядерного фактора каппа-В (RANKL) при диабетической нейроостеоартропатии и облитерирующем атеросклерозе артерий нижних конечностей // Сахарный диабет. — 2007. — №2. — С. 24–28. [Yaroslavtceva MV, Ulianova IN, Galstian GR. Sistema osteoprotegerin (OPG)-ligand receptora-activatora yadernogo factora kappa-B (RANKL) pri diabeticheskoy neuroosteoartropatii i obliteriruyuschem aterosklerose arterii nizhnih konechnostei. Diabetes Mellitus. 2007;(2):24−28. (In Russ.)] doi: https://doi.org/10.14341/2072-0351-5792
5. Palena LM, Brocco E, Ninkovic S, et al. Ischemic Charcot foot: different disease with different treatment? J Cardiovasc Surg (Torino). 2013;54(5):561–566.
6. Рекомендации ЕОК/ЕОСХ по диагностике и лечению заболеваний периферических артерий 2017 // Российский кардиологический журнал. 2018;23(8) [интернет-ресурс]. [2017 ESC guidelines on the diagnosis and treatment of peripheral arterial diseases, in collaboration with the European Society for vascular surgery (ESVS). Russian journal of cardiology. 2018;23(8) [online resource]. (In Russ.)] Доступно по: http://www.scardio.ru/content/Guidelines/8_rkj_2018_recomendation_2.pdf. Ссылка активна на 15.07.2019.
7. Milne T, Rogers J, Kinnear E, et al. Developing an evidence-based clinical pathway for the assessment, diagnosis and management of acute Charcot neuro-arthropathy: a systematic review. J Foot Ankle Res. 2013;6(1):30. doi: https://doi.org/10.1186/1757-1146-6-30
8. Chantelau E, Richter A. The acute diabetic Charcot foot managed on the basis of magnetic resonance imaging — a review of 71 cases. Swiss Med Wkly. 2013;143:w13831. doi: https://doi.org/10.4414/smw.2013.13831
Supplementary files
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1. Fig. 1. Foot of patient 1 at the first examination. | |
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2. Fig. 2. X-ray of the foot of the patient 1. | |
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3. Fig. 3. Axial section of MRI tomograms. Fat reduction mode. The defeat of the I, II sphenoid, scaphoid, proximal head of the II metatarsal, possibly III sphenoid bone (light areas - bone marrow edema). | |
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4. Fig. 4. Foot of patient 2 at the first examination. | |
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5. Fig. 5. Radiograph of the patient’s foot 2. Direct projection. | |
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6. Fig. 6. Radiograph of the patient’s foot 2. Lateral projection. | |
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7. Fig. 7. The foot of patient 2 during examination 21.01.2019. | |
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8. Fig. 8. The initial MRI of the foot. Fat reduction mode. Sagittal section. Swelling of the bones of the tarsus, proximal head of the II metatarsal bone, cuboid, talus, calcaneus. Sphenoid bone destruction. | |
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9. Fig. 9. MRI tomogram of the foot from 01.2019. Fat reduction mode. Sagittal section. The edema of the cuboid bone has decreased, edema of the talus and calcaneus is not determined. The rest is without dynamics. | |
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Review
For citations:
Demina A.G., Bregovskiy V.B., Karpova I.A. Combination of active stage of diabetic Charcot neuroosteoarthropathy and diabetic lower limb macroangiopathy. Diabetes mellitus. 2019;22(5):491-498. (In Russ.)