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Peripheral arterial disease and indicators of low-grade inflammation in patients with coronary artery disease and type 2 diabetes mellitus

https://doi.org/10.14341/DM9392

Abstract

BACKGROUND: The study of low-grade inflammation in patients with type 2 diabetes mellitus (T2DM) and atherosclerotic cardiovascular diseases is a pressing problem. A deeper understanding of the cascade of inflammatory reactions, possibly mediating the severe atherosclerotic lesions of various vascular pools in patients with diabetes, has the potential to introduce more sophisticated diagnostic and therapeutic approaches into practice.


AIM: To study the interrelation of low-grade inflammation and atherosclerosis of peripheral arteries in patients with coronary artery disease (CAD) and T2DM.


MATERIALS AND METHODS: The study included 137 patients (77 men and 60 women) with CAD. The average age of patients was 62.0 (57.0–66.0) years. The first group included 67 patients with CAD and T2DM, and the second group included 70 patients with CAD. Low-grade inflammation was assessed by the levels of high-sensitivity C-reactive protein, interleukin (IL)-1β, IL-6, IL-8, IL-10 and TNF-α. All patients underwent duplex scanning of carotid arteries and lower extremity arteries (LEAs).


RESULTS: Patients with CAD and T2DM showed significantly greater values of stenosis of carotid arteries and LEAs. Direct correlation was revealed between markers of inflammation and the degree of stenosis of the femoral and tibial arteries, as well as the intima-media thickness of the carotid and femoral arteries. In the group of patients with T2DM, the value of IL-1β was 2.04 (0.98–2.52) pg/mL, which was significantly less than 2.43 (1.84–3.19) pg/mL for patients in the second group (p = 0.010). The values of IL-6 were also significantly lower in the first group of patients, at 1.84 (0.73–4.41) pg/mL vs. 3.73 (2.27–10.2) pg/mL in the first and second groups, respectively (p = 0.008). The dose of metformin was inversely correlated with the level of IL-6 (r = −0.314, p = 0.003).


CONCLUSIONS: Patients with CAD and T2DM compared with patients without diabetes had significantly greater values of stenosis of peripheral arteries. The levels of IL-1β and IL-6 in the group of patients with CAD and T2DM were significantly lower in comparison with patients without diabetes. The dose of metformin was inversely correlated with the level of IL-6.

About the Authors

Vadim V. Genkel

South-Ural State Medical University


Russian Federation

assistant, Department of Internal Medicine


Competing Interests:

No conflict of interests



Karina V. Nikushkina

South-Ural State Medical University


Russian Federation

PhD, research institute of Immunology





Competing Interests:

No conflict of interests



Tansilla I. Nikonova

South-Ural State Medical University


Russian Federation

junior scientist researcher, research institute of Immunology


Competing Interests:

No conflict of interests



Igor I. Shaposhnik

South-Ural State Medical University


Russian Federation

MD, PhD, Professor, Heaf of Department of Internal Medicine


Competing Interests:

No conflict of interests



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Supplementary files

1. Fig. 1. Interleukin-6 levels in patients depending on metformin therapy.
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Type Исследовательские инструменты
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For citations:


Genkel V.V., Nikushkina K.V., Nikonova T.I., Shaposhnik I.I. Peripheral arterial disease and indicators of low-grade inflammation in patients with coronary artery disease and type 2 diabetes mellitus. Diabetes mellitus. 2018;21(3):178-185. (In Russ.) https://doi.org/10.14341/DM9392

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ISSN 2072-0351 (Print)
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