Possible applications of gliptins (dipeptidyl peptidase-4 inhibitors) in patients with type 2 diabetes mellitus on the various modes of insulin therapy
https://doi.org/10.14341/DM7624
Abstract
The evidence for DPP-4 inhibitors effectiveness at the late stages of type 2 diabetes mellitus (T2DM) are still growing. This is particularly important for those patients who receive insulin without adequately glycemic control. This publication provides the overview of studies which demonstrate high efficacy of Vildagliptin in reducing the blood glucose level in patients with hight duration of T2DM and insulin therapy. DPP-4 inhibitors normalize basal and postprandial glucagon secretion with pancreas α-cells that helps to provide better glycemic control and to reduce a risk of hypoglycemia. Besides, there are very interesting data for Vildagliptin to reduce insulin requirement in T2DM patients in addition to HbA1clevel decrease.
About the Authors
Gagik Radikovich Galstyan
Endocrinology Research Centre; Sechenov First Moscow State Medical University
Russian Federation
MD, PhD, Professor, Head of the Diabetic Foot Department at Diabetes Institute
Russian Federation
MD, PhD, Professor, Head of the Diabetic Foot Department at Diabetes Institute
Svetlana Viktorovna Sergeeva
Endocrinology Research Centre
Russian Federation
MD
Russian Federation
MD
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Review
For citations:
Galstyan G.R., Sergeeva S.V. Possible applications of gliptins (dipeptidyl peptidase-4 inhibitors) in patients with type 2 diabetes mellitus on the various modes of insulin therapy. Diabetes mellitus. 2015;18(4):87-91. (In Russ.) https://doi.org/10.14341/DM7624
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