Markers for gastrointestinal autoimmune disorders in patients with type 1 diabetes mellitus
https://doi.org/10.14341/DM2013428-32
Abstract
Aim.
to assess the occurrence of autoantibodies characteristic of autoimmune pancreatitis and gastritis in patients with type 1 diabetes mellitus (T1DM), and to analyze clinical features of positive subjects.
Materials and Methods.
84 patients (39 male, 45 female) with T1DM were subdivided into two groups and underwent biochemical, immunologic and instrumental examination.
Results.
Markers for gastrointestinal autoimmune disorders were found to be highly prevalent in patients with T1DM, even in those asymptomatic according to instrumental diagnostic methods.
Conclusion.
Our data suggests that T1DM patients are at higher risk of corresponding, possibly asymptomatic autoimmune disorders.
to assess the occurrence of autoantibodies characteristic of autoimmune pancreatitis and gastritis in patients with type 1 diabetes mellitus (T1DM), and to analyze clinical features of positive subjects.
Materials and Methods.
84 patients (39 male, 45 female) with T1DM were subdivided into two groups and underwent biochemical, immunologic and instrumental examination.
Results.
Markers for gastrointestinal autoimmune disorders were found to be highly prevalent in patients with T1DM, even in those asymptomatic according to instrumental diagnostic methods.
Conclusion.
Our data suggests that T1DM patients are at higher risk of corresponding, possibly asymptomatic autoimmune disorders.
About the Authors
Olga Sergeevna Derevyanko
Endocrinology Research Centre, Moscow
Russian Federation
postgraduate student
Russian Federation
postgraduate student
Nadezhda Sergeevna Dalantaeva
Endocrinology Research Centre, Moscow
Russian Federation
postgraduate student
Russian Federation
postgraduate student
Elena Vladimirovna Pekareva
Endocrinology Research Centre, Moscow
Russian Federation
MD, PhD, Senior Researcher in Diabetic Education and treatment department
Russian Federation
MD, PhD, Senior Researcher in Diabetic Education and treatment department
Olga Nikolaevna Ivanova
Endocrinology Research Centre, Moscow
Russian Federation
PhD, Leading Researcher, Head of genetic and clinical immunology laboratory
Russian Federation
PhD, Leading Researcher, Head of genetic and clinical immunology laboratory
Nikolay Petrovich Goncharov
Endocrinology Research Centre, Moscow
Russian Federation
MD, PhD, Professor, Head of laboratory for hormone analisis
Russian Federation
MD, PhD, Professor, Head of laboratory for hormone analisis
Tatiana Vasil'evna Nikonova
Endocrinology Research Centre, Moscow
Russian Federation
MD, PhD, Leading Researcher in Diabetic education and treatment department
Russian Federation
MD, PhD, Leading Researcher in Diabetic education and treatment department
Olga Mikhailovna Smirnova
Endocrinology Research Centre, Moscow
Russian Federation
MD, PhD, Professor, Chief Researcher in Diabetic education and treatment department
Russian Federation
MD, PhD, Professor, Chief Researcher in Diabetic education and treatment department
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Review
For citations:
Derevyanko O.S., Dalantaeva N.S., Pekareva E.V., Ivanova O.N., Goncharov N.P., Nikonova T.V., Smirnova O.M. Markers for gastrointestinal autoimmune disorders in patients with type 1 diabetes mellitus. Diabetes mellitus. 2013;16(4):28-32. https://doi.org/10.14341/DM2013428-32
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