Arterial diseases of lower extremities in diabetic patients: current state and prospects of therapy
https://doi.org/10.14341/2072-0351-6253
Abstract
Peripheral artery diseases (PAD) are most serious diabetic complications responsible for the high risk of amputation of lower extremities. The occurrenceof PAD in diabetic patients is much higher than in subjects with undisturbed carbohydrate metabolism. PAD in diabetic patients is frequentlyan asymptomatic condition affecting distal portions of arterial segments and associated with pronounced mediacalcinosis. Standard diagnostic proceduresfor the screening of arterial lesions must be supplemented by non-invasive visualization and measurement of transcutaneous oxygen tensionin patients at risk of PAD and persisting foot ulcers. Of special importance is early diagnosis of critical limb ischemia and prevention of foot lesions.Combined treatment of diabetic foot syndrome in patients with critical limb ischemia includes normalization of foot circulation, surgical interventionand conservative therapy of the wound, monitoring concomitant micro- and macrovascular diabetic complications?
About the Authors
Gagik Radikovich Galstyan
Endocrinology Research Centre, Moscow
Alla Yur'evna Tokmakova
Endocrinology Research Centre, Moscow
Olga Nikolaevna Bondarenko
Endocrinology Research Centre, Moscow
Ivan Ivanovich Sitkin
Endocrinology Research Centre, Moscow
Kira Yur'evna Pryakhina
Endocrinology Research Centre, Moscow
Valeriy Afanas'evich Mitish
Endocrinology Research Centre, Moscow
Lyubov' Petrovna Doronina
Endocrinology Research Centre, Moscow
References
1. Criqui M. Peripheral arterial disease: epidemiological aspects // Vascular Medicine. - 2001. - № 6 (suppl. 1). - Р. 3-7.
2. Hirsch A.T. et al PAD, detection, awareness and treatment in primary care // JAMA. - 2001. - № 286. - Р. 1317- 1324.
3. Fowkes F.G., Housley E., Cawood E.H. et al. Edinburgh Artery Study: prevalence of asymptomatic and symptomatic peripheral arterial disease in the general population // Int. J. Epidemiol. - 1991. - № 20(2). - Р. 384-92.
4. Jager K.A., Philips D.J., Martin R.L. et al. Noninvasive mapping of lower limb arterial lesions // Ultrasound Med. Biol. - 1985. - № 11. - Р. 515-521.
5. Bondarenko O., Pryakhina K., Galstyan G., Sitkin I. Duplex scanning compared with digital subtraction angiography in verification of peripheral arterial disease in diabetic patients. IX meeting of the DFSG (Diabetic Foot Study Group of the EASD). - 2010.
6. Graziani L. et al. // Eur J Vasc Endovasc Surg. - 2005. - № 29. - Р. 620-7.
7. Standarts of Care in Diabetes. American Diabetes Association // Diabetes Care. - 2010. - № 1. - Р. 12-65.
8. Dormandy J., Rutherford R. Management of peripheral arterial disease (PAD) TASC Working group // J. Vasc. Surg. - 2007. - № 31. - S1- S296.
9. Hiatt W. Medical treatment of peripheral arterial disease and claudication // N. Engl. J. Med. - 2001. - № 344. - Р. 1608-1621.
10. Regenshtiener J., Ware J. McCarthy W., Zhang P, Forbes W. Heckman J, Hiatt W. Effect of cilostazol on treatment of patients with PAD // J. Am. Geriatr. Soc. - 2002. - № 50. - Р. 1939-1946.
11. Peripheral arterial disease in people with diabetes. Consensus statement // Diabetes Care. - 2003. - V. 26. - № 12.
Review
For citations:
Galstyan G.R., Tokmakova A.Yu., Bondarenko O.N., Sitkin I.I., Pryakhina K.Yu., Mitish V.A., Doronina L.P. Arterial diseases of lower extremities in diabetic patients: current state and prospects of therapy. Diabetes mellitus. 2011;14(1):74-80. (In Russ.) https://doi.org/10.14341/2072-0351-6253
Views:
15784
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND 4.0).
Email this article 
