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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">diaendo</journal-id><journal-title-group><journal-title xml:lang="ru">Сахарный диабет</journal-title><trans-title-group xml:lang="en"><trans-title>Diabetes mellitus</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2072-0351</issn><issn pub-type="epub">2072-0378</issn><publisher><publisher-name>Endocrinology research centre</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14341/2072-0351-6253</article-id><article-id custom-type="elpub" pub-id-type="custom">diaendo-6253</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Articles</subject></subj-group></article-categories><title-group><article-title>Заболевания артерий нижних конечностей у пациентов с сахарным диабетом: состояние проблемы и перспективы лечения</article-title><trans-title-group xml:lang="en"><trans-title>Arterial diseases of lower extremities in diabetic patients: current state and prospects of therapy</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Галстян</surname><given-names>Гагик Радикович</given-names></name><name name-style="western" xml:lang="en"><surname>Galstyan</surname><given-names>Gagik Radikovich</given-names></name></name-alternatives><email xlink:type="simple">foot@endocrincentr.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Токмакова</surname><given-names>Алла Юрьевна</given-names></name><name name-style="western" xml:lang="en"><surname>Tokmakova</surname><given-names>Alla Yur'evna</given-names></name></name-alternatives><email xlink:type="simple">-</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бондаренко</surname><given-names>Ольга Николаевна</given-names></name><name name-style="western" xml:lang="en"><surname>Bondarenko</surname><given-names>Olga Nikolaevna</given-names></name></name-alternatives><email xlink:type="simple">-</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ситкин</surname><given-names>Иван Иванович</given-names></name><name name-style="western" xml:lang="en"><surname>Sitkin</surname><given-names>Ivan Ivanovich</given-names></name></name-alternatives><email xlink:type="simple">-</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пряхина</surname><given-names>Кира Юрьевна</given-names></name><name name-style="western" xml:lang="en"><surname>Pryakhina</surname><given-names>Kira Yur'evna</given-names></name></name-alternatives><email xlink:type="simple">-</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Митиш</surname><given-names>Валерий Афанасьевич</given-names></name><name name-style="western" xml:lang="en"><surname>Mitish</surname><given-names>Valeriy Afanas'evich</given-names></name></name-alternatives><email xlink:type="simple">-</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Доронина</surname><given-names>Любовь Петровна</given-names></name><name name-style="western" xml:lang="en"><surname>Doronina</surname><given-names>Lyubov' Petrovna</given-names></name></name-alternatives><email xlink:type="simple">-</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГУ Эндокринологический научный центр, Москва</institution></aff><aff xml:lang="en"><institution>Endocrinology Research Centre, Moscow</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2011</year></pub-date><pub-date pub-type="epub"><day>15</day><month>03</month><year>2011</year></pub-date><volume>14</volume><issue>1</issue><issue-title>№1 (2011)</issue-title><fpage>74</fpage><lpage>80</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Галстян Г.Р., Токмакова А.Ю., Бондаренко О.Н., Ситкин И.И., Пряхина К.Ю., Митиш В.А., Доронина Л.П., 2011</copyright-statement><copyright-year>2011</copyright-year><copyright-holder xml:lang="ru">Галстян Г.Р., Токмакова А.Ю., Бондаренко О.Н., Ситкин И.И., Пряхина К.Ю., Митиш В.А., Доронина Л.П.</copyright-holder><copyright-holder xml:lang="en">Galstyan G.R., Tokmakova A.Y., Bondarenko O.N., Sitkin I.I., Pryakhina K.Y., Mitish V.A., Doronina L.P.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.dia-endojournals.ru/jour/article/view/6253">https://www.dia-endojournals.ru/jour/article/view/6253</self-uri><abstract><p>Заболевания периферических артерий (ЗПА) относятся к числу наиболее опасных осложнений сахарного диабета (СД), определяющихвысокий риск ампутаций нижних конечностей. Частота ЗПА среди пациентов с СД значительно выше, чем у лиц без нарушений угле-водного обмена. Особенностью течения ЗПА при СД является частое бессимптомное течение, дистальный тип поражения артериаль-ных сегментов, выраженный медиакальциноз. Стандартные диагностические процедуры для скрининга поражений артерий нижнихконечностей должны дополняться неинвазивными визуализирующими методами и определением транскутанного напряжения кислородау пациентов с факторами риска ЗПА, длительно незаживающими язвенными дефектами стоп. Особенно важно своевременное выявлениесостояния критической ишемии конечности и предотвращение образования ран на стопе. При наличии синдрома диабетической стопына фоне критической ишемии необходимо комплексное лечение больных, включающее восстановление кровотока в стопе, хирургическоеи консервативное лечение раны, мониторинг сопутствующих микрососудистых и макрососудистых осложнений СД.</p></abstract><trans-abstract xml:lang="en"><p>Peripheral artery diseases (PAD) are most serious diabetic complications responsible for the high risk of amputation of lower extremities. The occurrenceof PAD in diabetic patients is much higher than in subjects with undisturbed carbohydrate metabolism. PAD in diabetic patients is frequentlyan asymptomatic condition affecting distal portions of arterial segments and associated with pronounced mediacalcinosis. Standard diagnostic proceduresfor the screening of arterial lesions must be supplemented by non-invasive visualization and measurement of transcutaneous oxygen tensionin patients at risk of PAD and persisting foot ulcers. Of special importance is early diagnosis of critical limb ischemia and prevention of foot lesions.Combined treatment of diabetic foot syndrome in patients with critical limb ischemia includes normalization of foot circulation, surgical interventionand conservative therapy of the wound, monitoring concomitant micro- and macrovascular diabetic complications?</p></trans-abstract><kwd-group xml:lang="ru"><kwd>заболевания периферических артерий</kwd><kwd>критическая ишемия</kwd><kwd>медиакальциноз</kwd><kwd>синдром диабетической стопы</kwd></kwd-group><kwd-group xml:lang="en"><kwd>peripheral artery diseases</kwd><kwd>critical ischemia</kwd><kwd>mediacalcinosis</kwd><kwd>diabetic foot syndrome</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Criqui M. Peripheral arterial disease: epidemiological aspects // Vascular Medicine. - 2001. - № 6 (suppl. 1). - Р. 3-7.</mixed-citation><mixed-citation xml:lang="en">Criqui M. Peripheral arterial disease: epidemiological aspects // Vascular Medicine. - 2001. - № 6 (suppl. 1). - Р. 3-7.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Hirsch A.T. et al PAD, detection, awareness and treatment in primary care // JAMA. - 2001. - № 286. - Р. 1317- 1324.</mixed-citation><mixed-citation xml:lang="en">Hirsch A.T. et al PAD, detection, awareness and treatment in primary care // JAMA. - 2001. - № 286. - Р. 1317- 1324.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Fowkes F.G., Housley E., Cawood E.H. et al. Edinburgh Artery Study: prevalence of asymptomatic and symptomatic peripheral arterial disease in the general population // Int. J. Epidemiol. - 1991. - № 20(2). - Р. 384-92.</mixed-citation><mixed-citation xml:lang="en">Fowkes F.G., Housley E., Cawood E.H. et al. Edinburgh Artery Study: prevalence of asymptomatic and symptomatic peripheral arterial disease in the general population // Int. J. Epidemiol. - 1991. - № 20(2). - Р. 384-92.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Jager K.A., Philips D.J., Martin R.L. et al. Noninvasive mapping of lower limb arterial lesions // Ultrasound Med. Biol. - 1985. - № 11. - Р. 515-521.</mixed-citation><mixed-citation xml:lang="en">Jager K.A., Philips D.J., Martin R.L. et al. Noninvasive mapping of lower limb arterial lesions // Ultrasound Med. Biol. - 1985. - № 11. - Р. 515-521.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Bondarenko O., Pryakhina K., Galstyan G., Sitkin I. Duplex scanning compared with digital subtraction angiography in verification of peripheral arterial disease in diabetic patients. IX meeting of the DFSG (Diabetic Foot Study Group of the EASD). - 2010.</mixed-citation><mixed-citation xml:lang="en">Bondarenko O., Pryakhina K., Galstyan G., Sitkin I. Duplex scanning compared with digital subtraction angiography in verification of peripheral arterial disease in diabetic patients. IX meeting of the DFSG (Diabetic Foot Study Group of the EASD). - 2010.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Graziani L. et al. // Eur J Vasc Endovasc Surg. - 2005. - № 29. - Р. 620-7.</mixed-citation><mixed-citation xml:lang="en">Graziani L. et al. // Eur J Vasc Endovasc Surg. - 2005. - № 29. - Р. 620-7.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Standarts of Care in Diabetes. American Diabetes Association // Diabetes Care. - 2010. - № 1. - Р. 12-65.</mixed-citation><mixed-citation xml:lang="en">Standarts of Care in Diabetes. American Diabetes Association // Diabetes Care. - 2010. - № 1. - Р. 12-65.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Dormandy J., Rutherford R. Management of peripheral arterial disease (PAD) TASC Working group // J. Vasc. Surg. - 2007. - № 31. - S1- S296.</mixed-citation><mixed-citation xml:lang="en">Dormandy J., Rutherford R. Management of peripheral arterial disease (PAD) TASC Working group // J. Vasc. Surg. - 2007. - № 31. - S1- S296.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Hiatt W. Medical treatment of peripheral arterial disease and claudication // N. Engl. J. Med. - 2001. - № 344. - Р. 1608-1621.</mixed-citation><mixed-citation xml:lang="en">Hiatt W. Medical treatment of peripheral arterial disease and claudication // N. Engl. J. Med. - 2001. - № 344. - Р. 1608-1621.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Regenshtiener J., Ware J. McCarthy W., Zhang P, Forbes W. Heckman J, Hiatt W. Effect of cilostazol on treatment of patients with PAD // J. Am. Geriatr. Soc. - 2002. - № 50. - Р. 1939-1946.</mixed-citation><mixed-citation xml:lang="en">Regenshtiener J., Ware J. McCarthy W., Zhang P, Forbes W. Heckman J, Hiatt W. Effect of cilostazol on treatment of patients with PAD // J. Am. Geriatr. Soc. - 2002. - № 50. - Р. 1939-1946.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Peripheral arterial disease in people with diabetes. Consensus statement // Diabetes Care. - 2003. - V. 26. - № 12.</mixed-citation><mixed-citation xml:lang="en">Peripheral arterial disease in people with diabetes. Consensus statement // Diabetes Care. - 2003. - V. 26. - № 12.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
