New glance at pathogenesis of type 2 diabetes mellitus: incretin and antiincretin systems.
https://doi.org/10.14341/2072-0351-6220
Abstract
Type 2 diabetes mellitus (T2 DM) is often seen in patients with obesity. Bariatric surgery, aimed to decrease body weight, can often help those patientsto improve glycemic status. After some of bariatric operations patients reach normoglycemia in few days, the fact that cant be explained onlyby reduction in weight. Recent trials revealed that the reorganization of gastrointestinal tract provides hypoglycemic effect of such operations. Thisarticle explains the role of proximal and distal gut in pathophysiology of T2 DM.
References
1. Moore B. On the treatment of diabetes mellitus by acid extract of duodenal mucose // Biochem. J. - 1906. - № 1. - Р. 28-38.
2. Toft-Niesen M.B., Damholt M.B., Madsbad S. et al. Determinants of the impaired secretion of glucagon-like peptide-1 in type 2 dia betic patients // J. Clin. Endocrinol. Metab. - 2001. - № 86. - Р. 3717-3723.
3. Яшков Ю.И. Возможности коррекции нарушений углеводного обмена при сахарном диабете 2 типа с применением бариатрических операций // Сахарный диабет. - 2000. - № 2. - С. 26-29.
4. Buchwald H., Adivor Y., Braunwald E. et al. Bariatric surgery: a systematic review and meta-analysis // JAMA. - 2004. - № 292. - Р. 1724-1737.
5. Ponce J., Haynes B., Paynter S. et al. Effect of lap-band-induced weight loss on type 2 diabetes mellitus and hypertension // Obes. Surg. - 2004. - № 14. - Р. 1335-1342.
6. Schauer P.R., Ikramuddin S., Gourash W. et al. Outcomes after laparoscopic roux-en-Y gastric bypass for morbid obesity // Ann. Surg. - 2000. - № 232. - Р. 515-529.
7. Pories W.J., Swanson M.S., MacDonald K.G. et al. Who would have thought it? An operation proves to be the most effective therapy for adultonset diabetes mellitus // Ann. Surg. - 1995. - № 222. - Р. 339-350.
8. Mason E.E. The mechanism of surgical treatment of type 2 diabetes // Obes. Surg. - 2005. - № 15. - Р. 459-461.
9. Patriti A., Facchiano E., Sanna A. The enteroinsular axis and the recovery from type 2 diabetes after bariatric surgery // Obes. Surg. - 2004. - № 14. - Р. 840-848.
10. Pories W.J., Albrecht R.J. Etiology of type II diabetes mellitus: role of the foregut // World J. Surg. - 2001. - № 25. - Р. 527-531.
11. Rubino F., Gagner M. Potential of surgery for curing type 2 diabetes mellitus // Ann. Surg. - 2002. - № 236. - Р. 554-559.
12. Borg C.M., Le Roux C.W., Ghatei M.A. et al. Progressive rise in gut hormone levels after Roux-en-Y gastric bypass suggests gut adaption and explains altered satiety // Br. J. Surg. - 2006. - № 93: 210-215.
13. Laferrere B., Heshka S., Wang K. et al. Incretin levels and effect are markedly enhanced 1 month after Roux-en-Y gastric bypass surgery in obese patients with type 2 diabetes // Diabetes Care. - 2007. - № 30. - Р. 1709-1716.
14. Le Roux C.W., Aylwin S.J., Batterham R.L. et al. Gut hormone profiles following bariatric surgery favor an anorectic state, facilitate weight loss, and improve metabolic parameters // Ann. Surg. - 2006. - № 243. - Р. 108-114.
15. Rubino F., Forgione A., Cummings D. et al. The mechanism of diabetes control after gastrointestinal bypass surgery reveals a role of the proximal small intestine in the pathophysiology of type 2 diabetes // Ann Surg. - 2006. - № 244. - Р. 741-749.
16. Meier J.J., Gallwitz B., Siepmann N. et al. Gastric inhibitory polypeptide (GIP) dose-dependantly stimulates glucagon secretion in healthy human subjects at euglycaemia // Diabetologia. - 2003. - № 46. - Р. 798-801.
17. Nauck M.A., Heimesaat M.M., Orskov C. et al. Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type 2 diabetes mellitus // J Clin Invest. - 1993. - № 91. - Р. 301-307.
18. Holst J.J., Pedersen J.H., Baldissera F. et al. Circulating glucagon after total pancreatectomy in man // Diabetologia. - 1983. - № 25. - Р. 396-399.
19. Kim S.K., MacDonald R.J. Signaling and transcriptional control of pancreatic organogenesis // Current Opinion in Genetics and Development. - 2002. - № 12. - Р. 540-547.
20. Meier J.J., Nauck M.A., Pott A. et al. Glucagon-like peptide 2 stimulates glucagon secretion, enhances lipid absorption, and inhibits gastric acid secretion in humans // Gastroenterology. - 2006. - № 130. - Р. 44-54.
Review
For citations:
Shestakova E.A. New glance at pathogenesis of type 2 diabetes mellitus: incretin and antiincretin systems. Diabetes mellitus. 2011;14(3):26-29. (In Russ.) https://doi.org/10.14341/2072-0351-6220
Views:
2665
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND 4.0).
Email this article 
