Overcoming marked insulin resistance in a patient with type 2 diabetes mellitus by means of insulin pumptherapy
https://doi.org/10.14341/2072-0351-6094
Abstract
Patients with type 2 diabetes mellitus (T2DM) often feature resistance to endogenous and exogenous insulin which is a serious problemto overcome. Current paper presents clinical case of T2DM characterized by marked insulin resistance, where high dosage regimenfailed to compensate carbohydrate metabolism. Regarding the case in question we discuss chronic insulin overdosage as one of the possiblefactors to interfere with compensation of diabetes, as well as capacity of insulin pump therapy to resolve such complicated clinicalsituation.
About the Authors
Ekaterina Viktorovna Artemova
Endocrinology Research Centre, Moscow
Irina Vladimirovna Kononenko
Endocrinology Research Centre, Moscow
Olga Mikhailovna Smirnova
Endocrinology Research Centre, Moscow
Alexander Yur'evich Mayorov
Endocrinology Research Centre, Moscow
References
1. Somogyi M. Exacerbation of diabetes by excess insulin action. Am J Med. 1959 Feb;26(2):169-191.
2. Касаткина ЭП. Сахарный диабет у детей. Издание 1-е. М: Медицина; 1990. 272 с.
3. Малая энциклопедия врача-эндокринолога. Под ред. АС Ефимова. 1-е изд. К: Медкнига; 2007. 360 с.
4. Deckert T, Hansen B, Lauritzen T, Christiansen JS. Subcutaneous degradation of insulin. Diabetologia. 1981 Aug;21(2):161-162.
5. Lauritzen T, Pramming S, Deckert T, Binder C. Pharmacokinetics оf Continuous Subcutaneous Insulin Infusion. Diabetologia. 1983 May;24(5):326-329.
6. Haffner SM, D'Agostino R Jr, Mykkänen L, Tracy R, Howard B, Rewers M, Selby J, Savage PJ, Saad MF. Insulin sensitivity in subjects with type 2 diabetes: relationship to cardiovascular risk factors: the Insulin Resistance Atherosclerosis Study. Diabetes Care. 1999 Apr;22(4):562-568.
7. Haffner SM, Agostino RD Jr, Saad MF, O'Leary DH, Savage PJ, Rewers M, Selby J, Bergman RN, Mykkänen L. Carotid artery atherosclerosis in type-2 diabetic and nondiabetic subjects with and without symptomatic coronary artery disease (The Insulin Resistance Atherosclerosis Study). Am J Cardiol. 2000 Jun 15;85(12):1395-1400.
8. Landsberg L, Young JB. Insulin-mediated glucose metabolismin the relationship between dietary intake and sympathetic nervous system activity. Int J Obes. 1985;9 Suppl 2:63-68.
9. Zang SL, Chen X, Hsieh TJ, Leclere M, Henley N, Allidina A, Halle JP, Brunette MG, Filep JC, Tang SS,Ingelfinger JR, Chan JS. Hyperflycemia induces insulin resistance on angiotensinogen gene expression in diabetic rat kidney proximal tubular cells. J Endocrinol. 2002; 172 (2): 333-344.
10. Burns KD. Angiotensin II and its receptors in the diabetic kidney. Am J Kidney Dis. 2000; 36 (3): 446-467.
11. Verdecchia P, Reboldi G, Schillaci G, Borgioni C, Ciucci A, Telera MP, Santeusanio F, Porcellati C, Brunetti P. Circulating Insulin and Insulin Growth Factor-1 Are Independent Determinants of Left Ventricular Mass and Geometry in Essential Hypertension. Circulation. 1999 Oct 26;100(17):1802-1807.
12. Sasson Z, Rasooly Y, Bhesania T, Rasooly I. Insulin resistance is an important determinant of left ventricular mass in the obese. Circulation. 1993 Oct;88(4 Pt 1):1431-1436.
13. Galvan AQ, Galetta F, Natali A, Muscelli E, Sironi AM, Cini G, Camastra S, Ferrannini E. Insulin Resistance and Hyperinsulinemia: No Independent Relation to Left Ventricular Mass in Humans. Circulation. 2000 Oct 31;102(18):2233-2238.
14. McNulty PH, Louard RJ, Deckelbaum LI, Zaret BL, Young LH. Hyperinsulinemia Inhibits Myocardial Protein Degradation in Patients With Cardiovascular Disease and Insulin Resistance. Circulation. 1995 Oct 15;92(8):2151-2156.
Review
For citations:
Artemova E.V., Kononenko I.V., Smirnova O.M., Mayorov A.Yu. Overcoming marked insulin resistance in a patient with type 2 diabetes mellitus by means of insulin pumptherapy. Diabetes mellitus. 2012;15(3):110-116. (In Russ.) https://doi.org/10.14341/2072-0351-6094
Views:
4368
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND 4.0).
Email this article 
