Excretion of amine nitrogen and ammonia in urine of pregnant women with type 1 diabetes mellitus
https://doi.org/10.14341/2072-0351-6063
Abstract
Aim.
To study excretion of amine nitrogen and ammonia in urine of pregnant women with type 1 diabetes mellitus depending on gestational ageand albuminuria level.
Materials and methods.
A total of 60 pregnant women with type 1 diabetes mellitus were examined. Proximal and distal tubular function was estimatedfrom daily excretion of amine nitrogen and ammonia respectively.
Results.
Daily excretion of amine nitrogen and ammonia in urine of pregnant women with type 1 diabetes mellitus was lower than in healthycontrols in the 2nd trimester regardless of albuminuria and in the 3rd trimester in patients with microalbuminuria (MAU) and proteinuria (PU).Ammonia excretion was twice lower than normal in the 2nd trimester in women with MAU and PU, and in the 3rd trimester in patients with PU.Healthy pregnant women showed significant correlation between ammonia and amine nitrogen excretion throughout pregnancy (r?0.833,p<0.05). In women with normal albuminuria strong correlation was recorded in the 1st and 2nd trimesters (r?0.7, p ?0.02); it was somewhatweaker (r=0.555, p=0.5) in the 3rd trimester. In the MAU group strong correlation (r=0.818, p=0.03) was documented in the 1st trimester andmoderate (r=0.574, p=0.033) in the 2nd trimester. No correlation between daily excretion of ammonia and amine nitrogen was found in the PUgroup.Conclusion: Renal tubular dysfunction increases with gestation age and severity of nephropathy.
To study excretion of amine nitrogen and ammonia in urine of pregnant women with type 1 diabetes mellitus depending on gestational ageand albuminuria level.
Materials and methods.
A total of 60 pregnant women with type 1 diabetes mellitus were examined. Proximal and distal tubular function was estimatedfrom daily excretion of amine nitrogen and ammonia respectively.
Results.
Daily excretion of amine nitrogen and ammonia in urine of pregnant women with type 1 diabetes mellitus was lower than in healthycontrols in the 2nd trimester regardless of albuminuria and in the 3rd trimester in patients with microalbuminuria (MAU) and proteinuria (PU).Ammonia excretion was twice lower than normal in the 2nd trimester in women with MAU and PU, and in the 3rd trimester in patients with PU.Healthy pregnant women showed significant correlation between ammonia and amine nitrogen excretion throughout pregnancy (r?0.833,p<0.05). In women with normal albuminuria strong correlation was recorded in the 1st and 2nd trimesters (r?0.7, p ?0.02); it was somewhatweaker (r=0.555, p=0.5) in the 3rd trimester. In the MAU group strong correlation (r=0.818, p=0.03) was documented in the 1st trimester andmoderate (r=0.574, p=0.033) in the 2nd trimester. No correlation between daily excretion of ammonia and amine nitrogen was found in the PUgroup.Conclusion: Renal tubular dysfunction increases with gestation age and severity of nephropathy.
About the Authors
Zulfiya Raisovna Alimetova
Republican Clinical Hospital, Kazan
Farida Vadutovna Valeeva
Kazan State Medical University, Kazan
References
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2. Алгоритмы специализированной медицинской помощи больным сахарным диабетом / Под ред. И.И. Дедова, М.В. Шестаковой. - М., 2007. - 112 с.
3. Нефрология. Руководство для врачей. В 2 томах. Том 1 / Под ред. И.Е. Тареевой. - М: Медицина, 1995. - 496 с.
Review
For citations:
Alimetova Z.R., Valeeva F.V. Excretion of amine nitrogen and ammonia in urine of pregnant women with type 1 diabetes mellitus. Diabetes mellitus. 2010;13(4):84-86. (In Russ.) https://doi.org/10.14341/2072-0351-6063
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