Russian Association of Endocrinologists expert consensus document on initiation and intensification of antyhyperglycaemic therapyin type 2 diabetes mellitus
https://doi.org/10.14341/2072-0351-5810
Abstract
Current consensus proposes a differentiated algorithm of initiation and intensification of antihyperglycaemic therapy in treatment patients withtype 2 diabetes mellitus. Patient-centered approach is considered a priority at any stage of diabetes care, as it ensures efficiency and safety of treatment.This document formulates guidelines for setting adequate therapeutic goals depending on vascular complications, age, life expectancy and riskof hypoglycemic events. Therapeutic options are stratified with regard to initial HbA1c level. This Algorithm considers all classes of antidiabetic medicationsregistered in Russian Federation, rational and irrational combinations of drugs as well as contraindications.
About the Authors
Ivan Ivanovich Dedov
Endocrinology Research Centre, Moscow
Marina Vladimirovna Shestakova
Endocrinology Research Centre, Moscow
Alexander Sergeevich Ametov
Russian Medical Academy of Postgraduate Education, Moscow
Mikhail Borisovich Antsiferov
Moscow Department of Health, Moscow
Gagik Radikovich Galstyan
Endocrinology Research Centre, Moscow
Alexander Yur'evich Mayorov
Endocrinology Research Centre, Moscow
Ashot Musaelovich Mkrtumyan
State University of Medicine and Dentistry, Moscow
Nina Alexandrovna Petunina
M. Sechenov First Moscow State Medical University, Moscow
Olga Yur'evna Sukhareva
Endocrinology Research Centre, Moscow
References
1. Алгоритмы специализированной медицинской помощи больным сахарным диабетом / Под ред. И.И. Дедова, М.В. Шестаковой. 5-й выпуск. - М., 2011.
2. Nathan D.M., Buse J.B., Davidson M.B., Heine R.J., Holman R.R., Sherwin R., Zinman B. Management of Hyperglycemia in Type 2 Diabetes: A Consensus Algorithm for the Initiation and Adjustment of Therapy. A consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes // Diabetes Care. - 2006. - № 29. - Р. 1963-1972.
3. Nathan D.M., Buse J.B., Davidson M.B., Ferranini E., Holman R.R., Sherwin R., Zinman B. American Diabetes Association; European Association for the Study of Diabetes. Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy. A consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes // Diabetes Care. - 2009. - № 32. - Р. 193-203.
4. Miller M.E., Byington R.P., Goff D.C.Jr., et al. (Action to Control Cardiovascular Risk in Diabetes Study Group). Effects of intensive glucose lowering in type 2 diabetes // N. Engl. J. Med. - 2008. - № 358. - Р. 2545-2559.
5. Patel A., MacMahon S., Chalmers J., et al (ADVANCE Collaborative Group). Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes // N. Engl. J. Med. - 2008. - № 358. - Р. 2560-2572.
6. Duckworth W., Abraira C., Moritz T., et al (VADT Investigators). Glucose control and vascular complications in veterans with type 2 diabetes [published correction appears in N Engl. J. Med. 2009;361:1024-1025, 1028] // N. Engl. J. Med. - 2009. - № 360. - Р. 129-139.
7. Rodbard H.W., Jellinger P.S., Davidson J.A., еt al. Statement by an American Association of Clinical Endocrinologists / American College of Endocrinology Consensus Panel on Type 2 Diabetes Mellitus: An Algorithm for Glycemic Control // Endocr. Pract. - 2009. - № 15(No. 6). - Р. 540-559.
8. Pospisilik J.A., Martin J., Doty T. et al. Dipeptidyl peptidase IV inhibitor treatment stimulates beta-cell survival and islet neogenesis in streptozotocininduced diabetic rats // Diabetes. - 2003. - № 52 (3). - Р. 741-750.
9. Mu J., Woods J., Zhou Y.P., Roy R.S., Li Z., Zycband E., Feng Y., Zhu L., Li C., Howard A.D., Moller D.E., Thornberry N.A., Zhang B.B. Chronic inhibition of dipeptidyl peptidase-4 with a sitagliptin analog preserves pancreatic -cell mass and function in a rodent model of type 2 diabetes // Diabetes. - 2006. - № 55. - Р. 1695-1704.
10. Sturis J., Gotfredsden C.F., Romer J. et al. GLP-1 derivative liraglutide in rats with beta-cell deficiencies: influence of metabolic state on beta-cell mass dynamics // Br. J. Pharmacol. - 2003. - № 140. - Р. 123-132.
11. Xu G., Stoffers D.A., Habener J.F., Bonner-Weir S. Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increasing betacell mass and improved glucose tolerance in diabetic rats // Diabetes. - 1999. - № 48. - Р. 2270-2276.
12. Gangji A.S., Cukierman T., Gerstein H.C. et al. A systematic review and meta-analysis of hypoglycemia and cardiovascular events: a comparison of glyburide with other secretagogues and with insulin // Diabetes Care. - 2007. - № 30. - Р. 389-394.
Review
For citations:
Dedov I.I., Shestakova M.V., Ametov A.S., Antsiferov M.B., Galstyan G.R., Mayorov A.Yu., Mkrtumyan A.M., Petunina N.A., Sukhareva O.Yu. Russian Association of Endocrinologists expert consensus document on initiation and intensification of antyhyperglycaemic therapyin type 2 diabetes mellitus. Diabetes mellitus. 2011;14(4):6-17. (In Russ.) https://doi.org/10.14341/2072-0351-5810
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