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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">diaendo</journal-id><journal-title-group><journal-title xml:lang="ru">Сахарный диабет</journal-title><trans-title-group xml:lang="en"><trans-title>Diabetes mellitus</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2072-0351</issn><issn pub-type="epub">2072-0378</issn><publisher><publisher-name>Endocrinology research centre</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14341/2072-0351-5810</article-id><article-id custom-type="elpub" pub-id-type="custom">diaendo-5810</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Articles</subject></subj-group></article-categories><title-group><article-title>Консенсус совета экспертов Российской ассоциации эндокринологов по инициации и интенсификации сахароснижающей терапии у больных сахарным диабетом 2 типа</article-title><trans-title-group xml:lang="en"><trans-title>Russian Association of Endocrinologists expert consensus document on initiation and intensification of antyhyperglycaemic therapyin type 2 diabetes mellitus</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дедов</surname><given-names>Иван Иванович</given-names></name><name name-style="western" xml:lang="en"><surname>Dedov</surname><given-names>Ivan Ivanovich</given-names></name></name-alternatives><email xlink:type="simple">-</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шестакова</surname><given-names>Марина Владимировна</given-names></name><name name-style="western" xml:lang="en"><surname>Shestakova</surname><given-names>Marina Vladimirovna</given-names></name></name-alternatives><email xlink:type="simple">nephro@endocrincentr.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Аметов</surname><given-names>Александр Сергеевич</given-names></name><name name-style="western" xml:lang="en"><surname>Ametov</surname><given-names>Alexander Sergeevich</given-names></name></name-alternatives><email xlink:type="simple">-</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Анциферов</surname><given-names>Михаил Борисович</given-names></name><name name-style="western" xml:lang="en"><surname>Antsiferov</surname><given-names>Mikhail Borisovich</given-names></name></name-alternatives><email xlink:type="simple">-</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Галстян</surname><given-names>Гагик Радикович</given-names></name><name name-style="western" xml:lang="en"><surname>Galstyan</surname><given-names>Gagik Radikovich</given-names></name></name-alternatives><email xlink:type="simple">-</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Майоров</surname><given-names>Александр Юрьевич</given-names></name><name name-style="western" xml:lang="en"><surname>Mayorov</surname><given-names>Alexander Yur'evich</given-names></name></name-alternatives><email xlink:type="simple">-</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мкртумян</surname><given-names>Ашот Мусаелович</given-names></name><name name-style="western" xml:lang="en"><surname>Mkrtumyan</surname><given-names>Ashot Musaelovich</given-names></name></name-alternatives><email xlink:type="simple">-</email><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Петунина</surname><given-names>Нина Александровна</given-names></name><name name-style="western" xml:lang="en"><surname>Petunina</surname><given-names>Nina Alexandrovna</given-names></name></name-alternatives><email xlink:type="simple">-</email><xref ref-type="aff" rid="aff-5"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сухарева</surname><given-names>Ольга Юрьевна</given-names></name><name name-style="western" xml:lang="en"><surname>Sukhareva</surname><given-names>Olga Yur'evna</given-names></name></name-alternatives><email xlink:type="simple">-</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ Эндокринологический научный центр, Москва</institution></aff><aff xml:lang="en"><institution>Endocrinology Research Centre, Moscow</institution></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ГБОУ ДПО Российская медицинская академия постдипломного образования, Москва</institution></aff><aff xml:lang="en"><institution>Russian Medical Academy of Postgraduate Education, Moscow</institution></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Эндокринологический диспансер Департамента здравоохранения г. Москвы, Москва</institution></aff><aff xml:lang="en"><institution>Moscow Department of Health, Moscow</institution></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>ГБОУ ВПО Московский государственный медико-стоматологический университет, Москва</institution></aff><aff xml:lang="en"><institution>State University of Medicine and Dentistry, Moscow</institution></aff></aff-alternatives><aff-alternatives id="aff-5"><aff xml:lang="ru"><institution>ГБОУ ВПО Первый Московский государственный медицинский университет им. И.М. Сеченова, Москва</institution></aff><aff xml:lang="en"><institution>M. Sechenov First Moscow State Medical University, Moscow</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2011</year></pub-date><pub-date pub-type="epub"><day>15</day><month>12</month><year>2011</year></pub-date><volume>14</volume><issue>4</issue><issue-title>№4 (2011)</issue-title><fpage>6</fpage><lpage>17</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Дедов И.И., Шестакова М.В., Аметов А.С., Анциферов М.Б., Галстян Г.Р., Майоров А.Ю., Мкртумян А.М., Петунина Н.А., Сухарева О.Ю., 2011</copyright-statement><copyright-year>2011</copyright-year><copyright-holder xml:lang="ru">Дедов И.И., Шестакова М.В., Аметов А.С., Анциферов М.Б., Галстян Г.Р., Майоров А.Ю., Мкртумян А.М., Петунина Н.А., Сухарева О.Ю.</copyright-holder><copyright-holder xml:lang="en">Dedov I.I., Shestakova M.V., Ametov A.S., Antsiferov M.B., Galstyan G.R., Mayorov A.Y., Mkrtumyan A.M., Petunina N.A., Sukhareva O.Y.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.dia-endojournals.ru/jour/article/view/5810">https://www.dia-endojournals.ru/jour/article/view/5810</self-uri><abstract><p>Настоящий консенсус Российской ассоциации эндокринологов (2011 г.) предлагает дифференцированный алгоритм инициации и интенсификации сахароснижающего лечения у больных сахарным диабетом 2 типа, ранее не получавших медикаментозной терапии.Приоритетом при выборе тактики ведения на любом этапе является индивидуальный подход к каждому пациенту, обеспечивающийэффективность и безопасность лечения.В консенсусе сформулированы принципы определения индивидуальных терапевтических целей с учетом имеющихся осложнений, возрастапациента, ожидаемой продолжительности жизни и риска гипогликемий.Выбор терапевтической тактики стратифицируется в зависимости от исходного уровня метаболического контроля (монотерапияили комбинированное лечение), при этом учтены все классы лекарственных препаратов, применяемых в Российской Федерации на на-стоящий момент, и обозначены рациональные и нерациональные комбинации сахароснижающих средств, а также противопоказанияк их применению.</p></abstract><trans-abstract xml:lang="en"><p>Current consensus proposes a differentiated algorithm of initiation and intensification of antihyperglycaemic therapy in treatment patients withtype 2 diabetes mellitus. Patient-centered approach is considered a priority at any stage of diabetes care, as it ensures efficiency and safety of treatment.This document formulates guidelines for setting adequate therapeutic goals depending on vascular complications, age, life expectancy and riskof hypoglycemic events. Therapeutic options are stratified with regard to initial HbA1c level. This Algorithm considers all classes of antidiabetic medicationsregistered in Russian Federation, rational and irrational combinations of drugs as well as contraindications.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>сахарный диабет 2 типа</kwd><kwd>консенсус Российской ассоциации эндокринологов</kwd><kwd>сахароснижающая терапия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>type 2 diabetes mellitus</kwd><kwd>Russian Association of Endocrinologists expert consensus</kwd><kwd>antihiperglycaemic therapy</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Алгоритмы специализированной медицинской помощи больным сахарным диабетом / Под ред. И.И. Дедова, М.В. Шестаковой. 5-й выпуск. - М., 2011.</mixed-citation><mixed-citation xml:lang="en">Алгоритмы специализированной медицинской помощи больным сахарным диабетом / Под ред. И.И. Дедова, М.В. 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