Возможности и проблемы трансплантации бета-клеток поджелудочной железы при сахарном диабете

На протяжении десятилетий проводятся исследования, направленные на возможность замещения у больных СД типа 1 утраченной функци и островков поджелудочной железы, восстановления функции инсулярного аппарата поджелудочной железы и нормальной регуляции углеводного обмена. Научные исследования проводятся по нескольким направлениям: аллогенная трансплантация поджелудочной железы или ее фрагментов; пересадка островко в поджелудочной железы, полученных от аллогенного или ксеногенного донора; разработка и создание искусственной поджелудочной железы.

поджелудочная железа, трансплантация, сахарный диабет

1. Gruessner A., Sutherland D. Е. R., Pancreas transplants for United States {US} and non US cases reported to International Pancreas Transplant Registry (IPTR) and to the United network for organ sharing (UNOS), In: Cecka M., Terasaki P (eds): Clinical transplants. 1997, Los Angeles, UCLA Tissue Typing laboratory, 1998

2. Ojo A. O., Meier-Kriesche H. U., Hanson J . A. et al., The impact of simultaneous pancreas- kidney transplantation on long-term patient survival / / Transplantation - 2001 -Vol.71 - P. 82-90

3. Reddy K. S., Stablein D., Taranto S. et al., Long-term survival following simultaneous kidney- pancreas transplantation versus kidney transplantation alone in patients with type 1 diabetes mellitus and renal failure / / Am J Kidney Dis - 2003 - Vol. 41 - P. 464-470

4. Bunnopradist S., Cho Y. W., Cecka J . M. et al., Kidney allograft and patient survival in type 1 diabetic recipients of cadaveric kidney alone versus simultaneous pancreas/kidney transplants: A multivariate analysis of the UNOS database / / J Am Soc Nephrol - 2003-Vol. 14-P. 208-213

5. Najarian J . S., Sutherland D. E. R., Matas A. J. et al. Human islet transplantation: a preliminary report / / Ttansplant. Proc. - 1 977. - Vol. 9. - P. 233-236

6. Kumar A., Newstead C. G., Lodge J. P., Davidson A. M., Combined kidney and pancreatic transplantation: ideal for patients with uncomplicated type 1 diabetes and chronic rensl failure / / В M J . - 1999. - Vol. 31 8. - P. 886-887

7. Holohan T.V., The federal role in health technology assessment / / Lancet - 1996 - Vol. 348 - P. 1006-1007

8. Шумаков В.И., Блюмкин В. H., Игнатенко С. Н. И др., Культуры островковых клкток поджелудочной железы плодов человека и трансплантация их больной сахарным диабетом / / Пробл. Эндокринол. - 1 981. - №1. - стр.25-30

9. Шумаков В. И., Блюмкин В. H., Игнатенко С. H. И др. Результаты трансплантации культур островковых клеток поджелудочной железы больным сахарным диабетом / / Пробл. Эндокринол. - 1985. - №5. - стр.67-70

10. Ricordi С , Lacy Р. Е., Finke Е/ et al. Automated method for isolation of human pancreatic islets// Diabetes. - 1988. - Vol. 37. - P. 413-420

11. Ricordi C , Lacy P. E., Scharp D. W. et al. Automated islet isolation from human pancreas / / Diabetes. - 1989. - Vol. 38. - Suppl. l . - P . 140-142

12. Alejandro R., Lehmann R., Ricordi C. et al., Long-term function {6 years) of islet allografts in type 1 diabetes mellitus / / Diabetes. - 1997. - Vol. 46. - P. 1983-1989

13. Hering B. J . , Ricordi C , Islet transplantation for patients with type 1 diabetes / / Graft Review. - 1999. - Vol. 2. - P. 12-27

14. Bertuzzi F., Grohovaz F., Maffi P. et al., Successful transplantation of human islet in pecipients bearing a kidney graft / / Diabetologia. - 2002. - Vol. 45. - P. 77-84

15. Kenyon N. S., Fernandez L. A., Lehmann R. et al., Long-term survival and function of intrahepatic islet allografts in baboons treated with humanized anti-CD 1 54 / / Diabetes - 1999 - Vol. 48 - P. 1473-1481

16. Contreras J. L., Eckhoff D. E., Cartner S. et al., Tolerability and side effects of anti-CD3- immunotoxin in preclinical testing in kidney and pancreatic islet transplant recipients / / Transplantation - 1999 - Vol. 68 - P. 215-219

17. Shapiro A. M., Lakey J . R., Ryan E. A. et al. Metabolic control after insulin independence in solitary islet transplantation for type 1 diabetes mellitus / / Diabetes. - 2000a. - Vol. 49. - Suppl. 1. -

18. Shapiro А. М., Lakey J. R., Ryan E. A. et al. Islet transplantation in seven patients with type 1 diabetes mellitus using a corticoid-free immunosuppressive regimen / / N. Engl. J. Med. - 2000b. - Vol. 27. - P. 230-238

19. Ryan E. A., Lakey J., Rajotte R. V. et al. Clinical outcomes and insulin secretion after islet transplantation with the Edmonton protocol / / Diabetes. - 2001. - Vol. 50. - P.710-719

20. Shapiro J . , Eighty years after insulin: Parallels with modern islet transplantation / / CMAJ - 2002 - Vol. 167-P. 1398-1400

21. Alejandro R., Caulfield A., Fround T. et al., Insulin independence following transplantation of cultured human islets / / Cell Transplant. - 2001. - Vol. 10. - P. 520

22. Alejandro R., Ferreira J. V., Caulfield A. et al., Insulin independence in 7 patients following transplantation of cultured human islets / / Am J Transplant. - 2002. - Vol. 2. - Suppl. 3. - P. 227

23. Ricordi C , Fraker C , Szust J . et al., Improved human islet isolation outcome from marginal donors following addition of oxygenated perfluorocarbon to the cold storage solution / / Transplantation. - 2003. - Vol. 75. - P. 1524-1527

24. Ricordi C , Linetsky E., Molano R. D. et al., High level stable hemolymphopoietic chimerism and long term islet allograft survival following novel targeted bone marrow radioablation, bone marrow transplantation and co-stimulatory blockade / / Transplantation. - 2002. - Vol. 74. - P. 99

25. Molano R.D., Pileggi A., Berney T. et al., Prolonged islet allograft survival in diabetic NOD mice by targeting CD45RB and CD 154 / / Diabetes. - 2003. - Vol. 53. - P. 957-964

26. Pileggi A., Molano R. D., Berney T. et al., HO-1 induction in islet cells results in protection from apoptosis and improved in vivo function after transplantation / / Diabetes. - 2001. - Vol. 50. - P. 1983-1991

27. Embury J . , Klein D., Pileggi et al., Proteins linked to a protein transduction domain (PTD) efficiently transduce pancreatic islets / / Diabetes. - 2001. - Vol. 50. - P. 1706-1713

28. Shapiro A. M., Gallant H., Hao E. et al., Portal vein immunosupressant levels and islet graft toxicity / / Transplant Proc. - 1998. - Vol. 30. - P. 641-645

29. Guba M., von Breitenbuch P., Steinbauer M. et al., Rapamicin inhibits primary and metastatic tumor growth by ontiangiogenesis: involvement of vascular endothelial growth factor / / Nature Med. - 2002. - Vol. 8. - P. 128-135

30. Berney Т., Molano R. D., Cattan P. et al., Endotoxin-mediated delayed islet graft function is associated with increased intra-islet cytokine production and islet cell apoptosis / / Transplantation. - 2001. - Vol. 70. - P. 125-1 32

31. Markmann J . , F., Rosen M., Siegelman E. S. et al., Magnetic resonance-defined periportal steatosis following intraportal islet transplantation / / Diebetes. - 2003. - Vol. 52. - P. 1591-1594

32. Ryan E. A., Lakey J., Paty B.W. et al., Successful islet transplantation: continued insulin reserve provides long-term glycemic control / / Diabetes - 2002 - Vol. 51 - P. 2148-2157

33. Moberg L., Johansson H., Lukinius A. et al., Poduction of tissue factor by pancreatic islet cells as a trigger of detrimental thrombotic reactions in clinical islet transplantation / / Lancet - 2002 - Vol. 360 - P. 2039-2045