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Topical problems of diabetes treatment during pregnancy

https://doi.org/10.14341/2072-0351-5701

Abstract

The main causes behind decompensation of diabetes mellitus (DM) in pregnant women are consid-ered, such as metabolic and hormonal disturbancesinfluencing insulin requirement in different periods of pregnancy and variability of glycemia related to pharmacokinetic and pharmacodynamicproperties of insu-lin preparations. Recommended target levels of glycemia in pregnant women with DM are cited. The fre-quencyof self-monitoring blood glucose and principles of intensive insulin therapy are discussed. Advan-tages of continuous subcutaneous insulin infusionand its role in the maintenance of stable control of car-bohydrate metabolism during pregnancy are discussed.

About the Authors

Irina Yur'evna Demidova
Russian State Medical University, Moscow


Natalya Yur'evna Arbatskaya
Russian State Medical University, Moscow; N.I. Pirogov City Clinical Hospital, Moscow


Elena Petrovna Mel'nikova
Russian State Medical University, Moscow


References

1. Kitzmiller J.L., Buchanan T.A., Kjos S., Combs C.A., Ratner R.E. Pre-conception care of diabetes, congenital malformation, and spontaneous abortion (ADA Technical Review) // Diabetes Care. - 1996. - 19. - Р. 514-541.

2. Ray J.G., O'Brien T.E., Chan W.S. Preconception care and the risk of congeni- tal anomalies in the offspring of women with diabetes mellitus: a meta-analysis // QJM. - 94. - Р.435-444, 2001.

3. Gabbe S.G., Graves C. Management of diabetes mellitus complicating preg-nancy // Obstet. Gynecol. - 2003. - 102. - Р. 857-868.

4. Kitzmiller J.L., Block J.M., Brown F.M., Catalano P.M., Conway D.L., Coustan D.R., L.D., Inturrisi M., Jovanovic L.B., Kjos S.I., Knopp R.H., Montoro M.N., Ogata E.S., Paramsothy P., Reader D.M., Rosenn B.M., Thomas A.M. Management of Preexisting Diabetes and Pregnancy. Alexandria, Virginia, American Diabetes As-sociation. - 2008.

5. Fetita L.S., Sobngwi E., Serradas P., Calvo F., Gautier J.F. Consequences of fetal exposure to maternal diabetes in offspring // J. Clin. Endocrinol. Metab. - 2006. - 91. - Р.3714-3724.

6. Parretti E., Mecaci F., Papini M., Cioni R., Carignani L., Mignosa M., La Torre P., Mello G. Third-trimester maternal blood glucose levels from diurnal profiles in nondiabetic pregnancies: correlation with sonographic parameters of fetal growth // Diabetes Care. - 2001. - 24. - Р. 1319-23.

7. Yogev Y. et al. Diurnal glycemic profile in obese and normal weight nondiabetic pregnant women // Am. J. Obstet. Gynecol. - 2004. - 191. - Р. 949-953.

8. Дедов И.И., Шестакова М.В. Алгоритмы специализированной медицинской помощи больным сахарным диабетом // Министерство здравоохранения РФ.-М., 2009.

9. Kauffman R.P. The Diabetes in Pregnancy Dilemma: Leading Change with Proven Solutions // J. Am. Med. Assoc. - 2006. - Vol. 296. - P. 1530- 1531.

10. Yogev Y., Chen R., Ben-Haroush A., Phillip M., Jovanovic L., Hod M. Continuouse glucose monitoring for the evaluation of gravid women with type 1 dia-betes mellitus // Obstet. Gynecol. - 2003. - 101. - Р. 633-638.

11. Nordsrom L., Spetz E., Wallstrom K., Walinder O. Metabolic control and pregnancy outcome among women with insulin-dependent diabetes mellitus // Acta. Diabetol. - 1998. - Vol. 77. - P. 284-289.

12. Jovanovic L., Peterson L., Peterson C.M., Reed G.F. et. Al. Meternal postprandial glucose levels predict birth weight; The Diabetes in Early Pregnancy Study. The Netional Institute of Child Health and Human Development-Diabetes in Early Pregnancy Study // Am. J. Obstet. Gynecol. - 1991. - Vol. 164. - P. 103-111.

13. Ben-Haroush A., Yogev Y., Chen R., Rosenn B., Hod M., Langer O. The postprandial glucose profile in the diabetic pregnancy // Am. J. Obst. Gyn. - 2004. - Vol. 191. - P. 576-581.

14. Gin H., Hanaire-Broutin H. Reproducibility and variability in the action of injected insulin // Diabetes. Metab. - 2005. - Vol. 31. - P. 7-13.

15. Lepore M., Pampanelli S., Fanelli C., Porcellati F. et al. Pharmacokinet-ics and pharmacodynamics of subcutaneous injection of long-acting insulin analog glargine, NPH insulin and ultralente human insulin and continuous subcutaneous in-fusion of insulin lispro // Diabetes. - 2000. - Vol. 49. - P. 42-48.

16. Schltz H.E., van Hiekerk N., Meyer B.N., Rosenkranz B. An assessment of the variability in the pharmacodynamics (glucose lowering effect of HOE901 compared to NPH and ultralente human insulin using the euglycemic clamp tech-nique) // Diabetologica. - 1999. - Vol. 42. - Supple. 1. - P. 882.

17. Anderson J., Brunelle R., Koivisto V. et al. Reduction of postprandial hyper-glycemia and frequency of hypoglycemia in IDDM patients on insulin- analogs treatment // Diabetes. - 1997. - Vol. 46. - P. 265-270.

18. Home P., Lindholm A., Hylleberg B., Round P. Improved glycemic control with insulin aspart: a multicenter randomized double-blind crossover trial in type 1 diabetic patients. UK Insulin Aspsrt Study Group // Diabet. Care. - 1998. - Vol. 21. - №11. - P. 1904-1909.

19. Lalli C., Ciofetta M., Del Sindaco P., et al. Long-term intensive treat-ment of type 1 diabetes with the short-acting insulin analog lispro in variable combi-nation with NPH insulin in mealtime // Diabetes Care. - 1999. - 22. - P. 468-477.

20. Schltz H.E., van Hiekerk N., Meyer B.N., Rosenkranz B. An assessment of the variability in the pharmacodynamics (glucose lowering effect of HOE901 compared to NPH and ultralente human insulin using the euglycemic clamp tech-nique) // Diabetologica. - 1999. - Vol. 42. - Supple. 1. - P. 882.

21. Lauritzen T., Pramming S., Deckert T., Binger C. Pharmacokinetics of continuous subcutaneous insulin infusion // Diabetologian. - 1983. - 24. - P. 326-329.

22. Castillo M.J., Scheen A., Lefebvre P.J. Treatment with insulin infusion pumps and ketoacidotic episodes: from physiology to troubleshooting // Diabetes. Metab. Rev. - 1995. - 11. - Р. 161-177.

23. Pfutzner J., Forst T., Butzer R., et al. Performance of the continuous glucose monitoring system (CGMS) during development of ketosis in patients on in-sulin pump therapy // Diabet. Med. - 2006. - Vol. 23. - P. 1124-1129.


Review

For citations:


Demidova I.Yu., Arbatskaya N.Yu., Mel'nikova E.P. Topical problems of diabetes treatment during pregnancy. Diabetes mellitus. 2009;12(4):32-36. (In Russ.) https://doi.org/10.14341/2072-0351-5701

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ISSN 2072-0351 (Print)
ISSN 2072-0378 (Online)