Parameters of metabolism and hemostasis in patients with type 1 diabetes mellitus and microgiopathy of different severity
https://doi.org/10.14341/2072-0351-5678
Abstract
Aim.
To identify risk factors of macro-microvascular lesions at different stages of pathological process in patients with type 1 diabetes mellitus andmicrogiopathy of different severity.
Materials and methods.
Comprehensive analysis of parameters of metabolism, hemogram, platelet and plasma hemostasis in 121 patients (67 menand 54 women of mean age 28.2?10.7 years) with type 1 diabetes mellitus and angiopathy of different severity.
Results.
All patients had hyperglycemia along with dysproteinemia and altered lipid spectrum. Mean platelet volume and aggregation activity increasedwhile activated partial thromboplastic time decreased compared with control subjects regardless of the presence and severity of microangiopathy.
Conclusion.
Morphological and functional characteristics of platelets and activated partial throm-boplastic time are differently related to metabolicchanges.
To identify risk factors of macro-microvascular lesions at different stages of pathological process in patients with type 1 diabetes mellitus andmicrogiopathy of different severity.
Materials and methods.
Comprehensive analysis of parameters of metabolism, hemogram, platelet and plasma hemostasis in 121 patients (67 menand 54 women of mean age 28.2?10.7 years) with type 1 diabetes mellitus and angiopathy of different severity.
Results.
All patients had hyperglycemia along with dysproteinemia and altered lipid spectrum. Mean platelet volume and aggregation activity increasedwhile activated partial thromboplastic time decreased compared with control subjects regardless of the presence and severity of microangiopathy.
Conclusion.
Morphological and functional characteristics of platelets and activated partial throm-boplastic time are differently related to metabolicchanges.
About the Authors
Galina Georgievna Petrik
Kuban’ State Medical University, Krasnodar
Svetlana Anatol'evna Pavlishchuk
Kuban’ State Medical University, Krasnodar
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Review
For citations:
Petrik G.G., Pavlishchuk S.A. Parameters of metabolism and hemostasis in patients with type 1 diabetes mellitus and microgiopathy of different severity. Diabetes mellitus. 2010;13(2):75-80. (In Russ.) https://doi.org/10.14341/2072-0351-5678
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