Glycated hemoglobin test: diagnostic difficulties in gestational diabetes
https://doi.org/10.14341/2072-0351-5540
Abstract
Aims.
To determine sensitivity and specificity of glycated hemoglobin (HbA1c) test with direct immunoturbidimetry as a method to diagnose gestational diabetes (GD).
Materials and Methods.
74 pregnant females were recruited during initial screening. Glycemic disorders were diagnosed with two methods: oral glucose tolerance test with 75 g of glucose and glycated hemoglobin test.
Results.
HbA1c test with direct immunoturbidimetry is a highly sensitive method for diagnosis of glycemic disorders of pregnancy, provided that cut-off level is lowered to 5.5%.
Conclusion.
Mild anemia was not found to have a significant impact on diagnostic value of HbA1c test.
To determine sensitivity and specificity of glycated hemoglobin (HbA1c) test with direct immunoturbidimetry as a method to diagnose gestational diabetes (GD).
Materials and Methods.
74 pregnant females were recruited during initial screening. Glycemic disorders were diagnosed with two methods: oral glucose tolerance test with 75 g of glucose and glycated hemoglobin test.
Results.
HbA1c test with direct immunoturbidimetry is a highly sensitive method for diagnosis of glycemic disorders of pregnancy, provided that cut-off level is lowered to 5.5%.
Conclusion.
Mild anemia was not found to have a significant impact on diagnostic value of HbA1c test.
About the Authors
Tatiana Vladimirovna Saprina
Siberian State Medical University
Russian Federation
Russian Federation
Ekaterina Sergeevna Timokhina
Siberian State Medical University
Russian Federation
Russian Federation
Irina Nikolaevna Vorozhtsova
Siberian State Medical University
Russian Federation
Russian Federation
References
1. Medved' VI, Bychkova EA. Opredelenie, klassifikacija i diagnosticheskie kriterii gestacionnogo diabeta: jevoljucija i sovremennoe sostojanie. Lіki Ukraїni. 2008; (6): 36-42. [Ukraine]
2. Ametov AS, Kazej NS, Murashko LE, Trusova NV. Gestacionnyj saharnyj diabet. Mezhdunarodnaja programma «Diabet». Jaroslavl'; 1995. p.30. [Russian]
3. Dedov II, Shestakova MV, Maksimova MA Federal'naja celevaja programma «Saharnyj diabet». Moskva; 2003. p. 84. [Russian]
4. Algoritmy spetsializirovannoi meditsinskoi pomoshchi bol'nym sakharnym diabetom. 3th ed. Ed by. Dedov II, Shestakova MV. Moscow; 2007. 86 p. [Russian]
5. Algoritmy spetsializirovannoi meditsinskoi pomoshchi bol'nym sakharnym diabetom. 4th ed. Ed by. Dedov II, Shestakova MV. Moscow; 2009. 86 p. [Russian]
6. Galstyan G.R. Nternational guidelines on the study of glycated hemoglobin HbA1c level as a diagnostic criterion for diabetes mellitus and other disorders of carbohydrate metabolism. Diabetes mellitus. 2010;(4):57-61. [Russian]
7. Ajlamazjan JeK, Tarasova MA, Zajcev AA. Роль эритропоэтина в патогенезе и лечении железодефицитной анемии при беременности и в послеродовом периоде. Z. Akus. Zen. Bolezn. 2003; LII(4):17-22.
8. Gorohovskaja GN, Zimaeva JuO. Zhelezodeficitnaja anemija u beremennyh. Trudnyj pacient. 2007;(9): 35-41. [Russian]
9. Il'in AV, Arbuzova MI, Knjazeva AP. Glikirovannyj gemoglobin kak kljuchevoj parametr pri monitoringe bol'nyh saharnym diabetom. Optimal'naja organizacija issledovanij. Diabetes mellitus. 2008;(2):60-64. [Russian]
Review
For citations:
Saprina T.V., Timokhina E.S., Vorozhtsova I.N. Glycated hemoglobin test: diagnostic difficulties in gestational diabetes. Diabetes mellitus. 2012;15(4):63-68. (In Russ.) https://doi.org/10.14341/2072-0351-5540
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