Insulin pump therapy in children with diabetes mellitus: practice of Krasnoyarsk Krai
https://doi.org/10.14341/2072-0351-5537
Abstract
Aim.
To summarize practical experience of insulin pump therapy (IPT) in child population of Krasnoyarsk and to assess its efficacy for treatment of type 1 diabetes mellitus (T1DM) in paediatrics.
Materials and Methods.
We performed a comparative analysis of clinical and laboratory data from 48 children with T1DM prior to and after 6-12 months of IPT.
Results.
IPT yielded fourfold decrease in complaints of hyperglycemia and labile glycemia without concurrent increase in reports of severe hypoglycemia. We observed a trend for lowering of mean HbA1c levels, where 65% of patients showed positive dynamics in comparison with the period of multiple daily injection regimen. Interestingly, after 6-12 months of IPT, insulin requirement dropped in most patients.
Conclusion.
Our data support clinical efficiency and safety of IPT, as well as superiority of this treatment over multiple daily injection regimen. We conclude that IPT is a treatment of choice for children with T1DM.
To summarize practical experience of insulin pump therapy (IPT) in child population of Krasnoyarsk and to assess its efficacy for treatment of type 1 diabetes mellitus (T1DM) in paediatrics.
Materials and Methods.
We performed a comparative analysis of clinical and laboratory data from 48 children with T1DM prior to and after 6-12 months of IPT.
Results.
IPT yielded fourfold decrease in complaints of hyperglycemia and labile glycemia without concurrent increase in reports of severe hypoglycemia. We observed a trend for lowering of mean HbA1c levels, where 65% of patients showed positive dynamics in comparison with the period of multiple daily injection regimen. Interestingly, after 6-12 months of IPT, insulin requirement dropped in most patients.
Conclusion.
Our data support clinical efficiency and safety of IPT, as well as superiority of this treatment over multiple daily injection regimen. We conclude that IPT is a treatment of choice for children with T1DM.
About the Authors
Tatiana Evgen'evna Taranushenko
Krasnoyarsk State Medical University
Russian Federation
Russian Federation
Viktoriya Nikolaevna Panfilova
Krasnoyarsk State Medical University
Russian Federation
Russian Federation
Oksana Alekseevna Terent'eva
Krasnoyarsk Regional Children's Hospital
Russian Federation
Russian Federation
Nadezhda Dmitrievna Koreshkova
Krasnoyarsk Regional Children's Hospital
Russian Federation
Russian Federation
Maria Nikolaevna Petrova
Krasnoyarsk Regional Children's Hospital
Russian Federation
Russian Federation
References
1. Dedov II, Peterkova VA, Kuraeva TL. Russian consensus on diabetes mellitus therapy in children and adolescents. Farmateka. 2010;197(3):7-14.
2. Peterkova VA, Kuraeva TL, Emel'yanov AO. Pump insulin therapy in pediatric practice. Pediatriya-Moscow. 2008; 87(5):46-50.
3. Peterkova VA, Kuraeva TL, Titovich EV. Sovremennaya insulinoterapiya sakharnogo diabeta 1 tipa u detey i podrostkov. Lechashchiy Vrach. 2003;(10):16-25.
4. Emel'yanov AO, Kuraeva TL, Peterkova VA. Insulin lizpro i pompovaya terapiya u detey i podrostkov. Russian medical journal. 2007;15(11):929-931.
5. Baranov AA, Albitsky VYu, Vinyarskaya IV, Valiullina SA. Studying quality of life in domestic pediatrics: results, goals and study prospects. Current pediatrics. 2007;6(3):6-8.
6. Lysenko IG. Medical and social aspects and quality of life of children with type 1 diabetes. Bulletin of the Multinational Center of Quality of Life Research. 2007; (9-10):109-114.
7. Bolotova NV, Kompaniec OV, Filina NYu, Nikolaeva NV. Assessment of quality of life as an element of monitoring health status in children and adolescents with type 1 diabetes mellitus. Diabetes mellitus. 2009;(3):57-59.
8. Samoylova YuG, Oleynik OA. Integral'nye pokazateli kachestva zhizni detey i podrostkov s sakharnym diabetom 1 tipa. Pediatriya-Moscow. 2010; 89(5):57-63.
9. Danne T, Aman J, Schober E, Deiss D, Jacobsen JL, Friberg HH, Jensen LH; ANA 1200 Study Group. A comparison of postprandial and pre-prandial administration of insulin aspart in children and adolescents with type 1 diabetes. Diabetes Care. 2003 Aug;26(8):2359-2364.
10. Ahern JA, Boland EA, Doane R, Ahern JJ, Rose P, Vincent M, Tamborlane WV. Insulin pump therapy in pediatrics: a therapeutic alternative to safely lower therapy HbA1c levels across all age groups. Pediatr Diabetes. 2002 Mar;3(1):10- 15.
11. Hoogma RP, Hammond PJ, Gomis R, Kerr D, Bruttomesso D, Bouter KP, Wiefels KJ, de la Calle H, Schweitzer DH, Pfohl M, Torlone E, Krinelke LG, Bolli GB; 5-Nations Study Group. Comparison of the effects of continuous subcutaneous insulin infusion (CSII) and NPH-based multiple daily insulin injections (MDI) on glycaemic control and quality of life: results of the 5-nations trial. Diabet Med. 2006 Feb;23(2):141-147.
Review
For citations:
Taranushenko T.E., Panfilova V.N., Terent'eva O.A., Koreshkova N.D., Petrova M.N. Insulin pump therapy in children with diabetes mellitus: practice of Krasnoyarsk Krai. Diabetes mellitus. 2012;15(4):46-60. (In Russ.) https://doi.org/10.14341/2072-0351-5537
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