Evaluation of the degree of metabolic compensation and prevalence of diabetic complications in a Russian population of childrenand adolescents (results of the ?Screening for diabetic complications and assessment of medical aid to diabetic patients? Project)

Aim.
To analyse the degree of compensation of disturbed carbohydrate metabolism and to evaluate its effect on the prevalence of diabetic complicationsin children and adolescents from 20 regions of RF.
Materials and methods.
A total of 2984 patients with DM1 were examined in 2002-2005 including 1532 children below 14 yr and 1452 adolescentsof 15-17 yr. The patients were selected from regional DM registries by the random number method.
Results.
Mean HbA1с was 9,77?2,30%. The number of children with compensated carbohydrate metabolism at the time of screening was significantlyhigher than that of adolescents (21,1 and 15,1% respectively, p<0,01) whereas the frequency of diabetic complications in the two groups showedthe inverse trend (non-proliferative retinopathy 3,3 and 15,8, p<0,01; diabetic cataract 4,6 and 11,5%, p<0,01; microalbuminuria 10,2 and30,9%, p<0,01; distal polyneuropathy 6,9 and 15,3, p<0,01). The highest prevalence of microalbuminuria and polyneuropathy was recorded inchildren and adolescents with DM1 duration over 10 years.
Conclusion.
The relative number of children and adolescents with compensated carbohydrate metabolism was 21,1 and 15,6% respectively. The prevalenceof diabetic complications was significantly higher in the elder age group.

diabetes mellitus, children, adolescents, screening for complications, glycated hemoglobin, retinopathy, polyneuropathy, microalbuminuria

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