Сахарный диабет и гемостаз. Интрига отношений. Часть 1. Дисфункция эндотелия

Данный обзор литературы является первым в серии статей, посвященных взаимному влиянию сахарного диабета (СД) и нарушений в системе гемостаза, связанных с дисфункцией эндотелия (ДЭ), изменениями активности тромбоцитов, плазменно-коагуляционного звена гемостаза, активности естественных антикоагулянтов и фибринолиза. Проанализированы основные механизмы развития ДЭ, возможности ее выявления не только в научных исследованиях, но и в рутинной клинической практике. Также приведены основные принципы как немедикаментозной, так и медикаментозной коррекции ДЭ. Сделан акцент на возможности использования с этой целью препаратов, обладающих сахароснижающим эффектом и не имеющих его. Высказано мнение о наличии обратного влияния ДЭ на дисбаланс углеводного обмена, которое, по мнению авторов, сможет значительно расширить представление о роли этих нарушений не только в развитии осложнений, но и в патогенезе самого СД.

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