Regeneration of β-cells of the islet apparatus of the pancreas. Literature review
https://doi.org/10.14341/DM12872
Abstract
Diabetes of both type 1 and type 2 is characterized by a progressive loss of β-cell mass, which contributes to the disruption of glucose homeostasis. The optimal antidiabetic therapy would be simple replacement of lost cells, but at present, many researchers have shown that the pancreas (PZ) of adults has a limited regenerative potential. In this regard, significant efforts of researchers are directed to methods of inducing the proliferation of β-cells, stimulating the formation of β-cells from alternative endogenous sources and/or the generation of β-cells from pluripotent stem cells. Factors that regulate β-cell regeneration under physiological or pathological conditions, such as mediators, transcription factors, signaling pathways and potential pharmaceuticals, are also being intensively studied. In this review, we consider recent scientific studies carried out in the field of studying the development and regeneration of insulin-producing cells obtained from exogenous and endogenous sources and their use in the treatment of diabetes. The literature search while writing this review was carried out using the databases of the RSIC, CyberLeninka, Scopus, Web of Science, MedLine, PubMed for the period from 2005 to 2021. using the following keywords: diabetes mellitus, pancreas, regeneration, β-cells, stem cells, diabetes therapy.
Supporting agencies: The study was financially supported by the Saratov State Medical University n.a. V.I. Razumovsky in the framework of the scientific project No. SSMU-2022-003.
About the Authors
T. E. Pylaev
Saratov State Medical University
Russian Federation
Competing Interests:
Russian Federation
Timofey E. Pylaev, PhD in Biology
Saratov
eLibrary SPIN: 7538-8957
Competing Interests:
Аuthor report no conflict of interest.
I. V. Smyshlyaeva
Saratov State Medical University
Russian Federation
Competing Interests:
Russian Federation
Irina V. Smyshlyaeva, MD, PhD, Associate Professor
Saratov
eLibrary SPIN: 9593-4739
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Аuthor report no conflict of interest.
E. B. Popyhova
Saratov State Medical University
Russian Federation
Competing Interests:
Russian Federation
Era B. Popyhova, PhD, senior research associate
137 Bol’shaya Sadovaya street, 410054, Saratov
eLibrary SPIN:7810-3930
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Аuthor report no conflict of interest
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Supplementary files
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1. Figure 1. Pancreatic cells that can give rise to islet β-cells (adapted from C. Aguayo-Mazzucato et al., 2018). | |
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2. Figure 2. Possible exogenous sources of pancreatic β-cells (adapted from F.M. Docherty and L. Sussel, 2021). | |
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Review
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Pylaev T.E., Smyshlyaeva I.V., Popyhova E.B. Regeneration of β-cells of the islet apparatus of the pancreas. Literature review. Diabetes mellitus. 2022;25(4):395-404. (In Russ.) https://doi.org/10.14341/DM12872
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