Potential risk factors for diabetes mellitus type 1
https://doi.org/10.14341/DM12573
Abstract
Diabetes mellitus type 1 (T1D) develops as a result of the interaction of genetic and environmental factors. Genetic predisposition to T1D turns into clinical reality only in half of hereditary cases, which indirectly indicates the importance of external factors, the significance of which is periodically reviewed. Retrospective and prospective clinical foreign and national studies were included. PubMed, Medline and eLibrary were searched. Modern ideas about the possible impact of the main prenatal and postnatal environmental factors on the development of autoimmune response against insulin-producing islet cells and T1D were discussed. The risk of developing type 1 diabetes is determined by the complex interaction of environmental factors and genetic predisposition. The mechanisms of their influence remain rather unknown. Further research is needed to determine strategies of primary and secondary prevention of T1D.
About the Authors
K. G. Korneva
Privolzhsky Research Medical University
Russian Federation
Russian Federation
Kseniya G. Korneva, MD, PhD, associate professor
10/1, Minin and Pozharsky square, 603005 Nizhny Novgorod
eLibrary SPIN: 5945-3266
L. G. Strongin
Privolzhsky Research Medical University
Russian Federation
Russian Federation
Leonid G. Strongin, MD, PhD, Professor
Nizhny Novgorod
eLibrary SPIN: 9641-8130
K. Yu. Nazarova
Privolzhsky Research Medical University
Kseniya Yu. Nazarova, clinical resident
Nizhny Novgorod
V. E. Zagainov
Privolzhsky Research Medical University
Vladimir E. Zagainov, MD, PhD, associate professor
Nizhny Novgorod
eLibrary SPIN: 6477-0291
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Korneva K.G., Strongin L.G., Nazarova K.Yu., Zagainov V.E. Potential risk factors for diabetes mellitus type 1. Diabetes mellitus. 2022;25(3):256-266. (In Russ.) https://doi.org/10.14341/DM12573
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