Diabetic nephropathy in type 1 diabetes and pregnancy. Modern view of the problem
Abstract
Diabetic nephropathy (DN) is specific kidney damage in patients with diabetes mellitus. DN develops relatively often in pregestational diabetes patients (5,9-26%) and stills one of the main limitations for successful pregnancy in this patients’ group. Advanced DN increases risks of poor pregnancy outcomes for women and fetuses including chronic kidney disease (CKD) progression, high rate of preeclampsia, preterm deliveries, Cesarean sections, perinatal mortality and neonatal morbidity. At the same time there are more and more successful pregnancies with advanced DN in the wold.
In our paper we systematize global experience of planning and management pregnancies with type 1 diabetes and DN in different stages of renal impairment. We discuss role of nephroprotective therapy in preconception care, achievement and maintaining blood pressure goals, multidisciplinary team care for improvement pregnancy outcomes in type 1 diabetic women with DN.
About the Authors
Ekaterina S. Shilova
The Research Institute of Obstetrics, Gynecology, and Reproductology named after D.O. Ott; Almazov National Medical Research Center
Russian Federation
Competing Interests: not
Russian Federation
eLibrary SPIN: 9703-5970
3, Mendeleyevskaya Line, 199034 St. Petersburg
Competing Interests: not
Natalya V. Borovik
The Research Institute of Obstetrics, Gynecology, and Reproductology named after D.O. Ott
Russian Federation
Competing Interests: not
Russian Federation
MD, PhD, eLibrary SPIN: 9010-7276.
St. Petersburg
Competing Interests: not
Maria I. Yarmolinskaya
The Research Institute of Obstetrics, Gynecology, and Reproductology named after D.O. Ott; North-Western State Medical University named after I.I. Mechnikov
Russian Federation
Competing Interests: not
Russian Federation
MD, PhD, Professor, eLibrary SPIN: 3686-3605
St. Petersburg
Competing Interests: not
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Shilova E.S., Borovik N.V., Yarmolinskaya M.I. Diabetic nephropathy in type 1 diabetes and pregnancy. Modern view of the problem. Diabetes mellitus. 2020;23(4):340-348. (In Russ.)
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