Preview

Diabetes mellitus

Advanced search

Combined or isolated transplantation of pancreas and kidney at the terminal stage of diabetic nephropathy

Abstract

This review of current foreign literature is focused on the analysis of different variants of pancreas and kidney transplantation in patients with terminalrenal insufficiency resulting from diabetic nephropathy. Most authors consider combined pancreas and kidney transplantation to be the method ofchoice for patients with this pathology. Given the adequately functioning pancreas implant, this operation ensures excellent engaftment of the kidneyimplant and survival of the recipient. An alternative method is isolated transplantation of a kidney from a live donor with subsequent transplantationof the pancreas. Isolated transplantation of a cadaveric kidney results in transplant and recipient.

About the Author

Malkhaz Viktorovich Kvaratskheliya
Endocrinological Research Centre, Moscow


References

1. Дедов И.И., Балаболкин М.И., Клебанова Е.М. Современные аспекты трансплантации островков поджелудочной железы при са- харном диабете. Эндокринологический научный центр РАМН. М. - 2005.

2. Gonzбlez-Posada J.M., Marrero D., Hernбndez D. et al. Pancreas transplantation: differences in activity between Europe and the United States // Nephrol. Dial. Transplant. - 2010. - Vol. 25. - P. 952-959.

3. Young B.Y., Jagbir G., Huang E. et al. Living Donor Kidney Versus Simultaneous Pancreas-Kidney Transplant in Type I Diabetics: An Analysis of the OPTN/UNOS Database // Clin. J. Am. Soc. Nephrol. - 2009. - Vol. 4. - P. 845-852.

4. American Diabetes Association: Pancreas transplantation for patients with type 1 diabetes // Diabetes Care. - 2000. - Vol. 23 (Suppl. 1). - S85.

5. Venstrom J.M., McBride M.A., Rother K.I. et al. Survival after pancreas transplantation in patients with diabetes and preserved renal function // JAMA. - 2003. - Vol. 290. - P. 2817-2823.

6. Gruessner R.W.G., Sutherland D.E.R., Gruessner A.C. Mortality assessment for pancreas transplants // Am. J. Transplant. - 2004. - Vol. 4. - P. 2018-2026.

7. Smets Y.F.C., Westendrop R.G.J., Van de Pijl J.W. et al. Effects of simultaneous pancreas-kidney transplantation on mortality of patients with type 1 diabetes mellitus and end stage renal failure // Lancet. - 1999. - Vol. 353. - P. 1915-1919.

8. Becker B.N., Brazy P.C., Becker Y.T. et al. Simultaneous pancreaskidney transplantation reduces excess mortality in type 1 diabetic patients with end-stage renal disease // Kidney Int. - 2000. - Vol. 57. - P. 2129-2135.

9. Ojo A.O., Meier-Kriesche H.U., Hanson JA et al. The impact of simultaneous pancreas-kidney transplantation on long term patient survival // Transplantation. - 2001. - Vol. 71. - P. 82-90.

10. Waiting List and Transplantation Figures according to European Standard 2002-2006. http://www.scandiatransplant.org 2 January 2009, date last accessed.

11. Sorensen V.R., Mathiesen E.R., Heaf J et al. Improved survival rate in patients with diabetes and end-stage renal disease in Denmark // Diabetologia. - 2007. - Vol. 50. - P. 922-929.

12. Gruessner A.C., Sutherland E.R. Pancreas transplant outcomes for United States (US) and non-US cases reported to the United Network for Organ Sharing (UNOS) and the International Pancreas Transplant Registry (IPTR) as of June 2004 // Clin. Transplant. - 2005. - Vol. 19. - P. 433-455.

13. Smets Y.F.C., Westendrop R.G.J., Van de Pijl J.W. et al. Effects of simultaneous pancreas-kidney transplantation on mortality of patients with type 1 diabetes mellitus and end stage renal failure // Lancet. - 1999. - Vol. 353. - P. 1915-1919.

14. Waki K., Terasaki P.I. Kidney graft and patient survival with and without a simultaneous pancreas utilizing contralateral kidney from the same donor // Diabetes Care. - 2006. - Vol. 29. - P. 1670-1672.

15. Morata C., Sйller M., Doler B. et al. Metabolic control improves longterm renal allograft and patients survival in type 1 diabetes // J. Am. Soc. Nephrol. - 2008. - Vol. 19. - P. 1557-1563.

16. Bunnapradist S., Cho Y.W., Cecka J.M., Wilkinson A., Danovitch G.M. Kidney allograft and patient survival in type I diabetic recipients of cadaveric kidney alone versus simultaneous pancreas kidney transplants: A multivariate analysis of the UNOS database // J. Am. Soc. Nephrol. - 2003. - Vol. 14. - P. 208-213.

17. Reddy K.S., Stablein D., Taranto S., Stratta R.J., Johnston T.D., Waid T.H., McKeown J.W., Lucas B.A., Ranjan D. Long-term survival following simultaneous kidney-pancreas transplantation versus kidney transplantation alone in patients with type 1 diabetes mellitus and renal failure // Am. J. Kidney Dis. - 2003. - Vol. 41. - P. 464-470.

18. Israni A.K., Feldman H.I., Propert K.J., Leonard M., Mange K.C. Impact of simultaneous kidney-pancreas transplant and timing of transplant on kidney allograft survival. // Am. J. Transplant. - 2005. - Vol. 5. - P. 374-382.

19. Becker B.N., Rush S.H., Dykstra D.M., Becker Y.T., Port F.K. Preemptive transplantation for patients with diabetes-related kidney disease // Arch. Intern. Med. - 2006. - Vol. 166. - P. 44-48.

20. Gaston R.S., Basadonna G., Cosio F.G., Davis C.L., Kasiske B.L., Larsen J., Leichtman A.B., Delmonico F.L. Transplantation in the diabetic patient with advanced chronic kidney disease: a task force report // Am. J. Kidney. Dis. - 2004. - Vol. 44. - P. 529-542.

21. Siddiqi N., McBride M.A., Hariharan S. Similar risk profiles for posttransplant renal dysfunction and long-term graft failure: UNOS/OPTN database analysis // Kidney Int. - 2004. - Vol. 65. - P. 1906-1913.

22. Giblin L., O'Kelly P., Little D., Hickey D., Donohue J., Walshe J.J., Spencer S., Conlon P.J. A comparison of long-term graft survival rates between the first and second donor kidney transplanted-the effect of a longer cold ischaemic time for the second kidney // Am. J. Transplant. - 2005. - Vol. 5. - P. 1071-1075.

23. Keith D.S., Demattos A., Golconda M., Prather J., Norman D. Effect of donor recipient age match on survival after first deceased donor renal transplantation // J. Am. Soc. Nephrol. - 2004. - Vol. 15. - P. 1086-1091.

24. Kauffman H.M., McBride M.A., Cors C.S., Roza A.M., Wynn J.J. Early mortality rates in older kidney recipients with comorbid risk factors // Transplantation. - 2007. - Vol. 83. - P. 404-410.

25. Gruessner R.W., Sutherland D.E., Gruessner A.C. Mortality assessment for pancreas transplants // Am. J. Transplant. - 2004. - Vol. 4. - P. 2018-2026.

26. Biesenbach G., Konigsrainer A., Gross C., Margreiter R. Progression of macrovascular diseases is reduced in type 1 diabetic patients after more than 5 years successful combined pancreas-kidney transplantation in comparison to Clin J Am Soc Nephrol 4: 845-852, 2009 LDKT Versus SPKT in Type I Diabetics 851 kidney transplantation alone // Transpl. Int. - 2005. - Vol. 18. - P. 1054-1060.

27. Orsenigo E., Socci C., Fiorina P., Zuber V., Secchi A., Di Carlo V., Staudacher C. Cardiovascular benefits of simultaneous pancreas-kidney transplant versus kidney alone transplant in diabetic patients // Transplant Proc. - 2005. - Vol. 37. - P. 3570-3571.

28. Hariharan S., Pirsch J.D., Lu C.Y., Chan L., Pesavento T.E., Alexander S., Bumgardner G.L., Baasadona G., Hricik D.E., Pescovitz M.D., Rubin N.T., Stratta R.J. Pancreas after kidney transplantation // J. Am. Soc. Nephrol. 2002. - Vol. 13. - P. 1109-1118.

29. Cohen D.J., St Martin L., Christensen L.L., Bloom R.D., Sung R.S. Kidney and pancreas transplantation in the United States, 1995-2004 // Am. J. Transplant. - 2006. - Vol. 6. - P. 1153-1169.

30. Weiss A.S., Smits G., Wiseman A.C. Twelve-Month Pancreas Graft Function Significantly Influences Survival Following Simultaneous Pancreas-Kidney Transplantation // Clin. J. Am. Soc. Nephrol. - 2009. - Vol. 4. - P. 988-995.

31. Steurer W., Bonatti H., Obrist P., Spechtenhauser B., Ladurner R., Mark W., Gardetto A., Margreiter R., Konigsrainer A. Incidence of intraabdominal infection in a consecutive series of 40 enteric-drained pancreas transplants with FK506 and MMF immuno suppres sion // Transpl. Int. - 2000. - Vol. 13 Suppl 1. - S195-S198.

32. Berger N., Wirmsberger R., Kafka R., Margreiter C., Ebenbichler C., Stelzmueller I., Margreiter R., Steurer W., Mark W., Bonatti H. Infectious complications following 72 consecutive enteric-drained pancreas transplants // Transpl. Int. - 2006. - Vol. 19. - P. 549-557.

33. Monroy-Cuadros M., Salazar A., Yilmaz S., McLaughlin K. Bladder vs enteric drainage in simultaneous pancreas-kidney transplantati on // Nephrol. Dial. Transplant. - 2006. - Vol. 21. - P. 483-487.

34. Port F.K., Merion R.M., Finley M.P., Goodrich N.P., Wolfe R.A. Trends in organ donation and transplantation in the United States, 1996- 2005 // Am. J. Transplant. - 2007. - Vol. 7. - P. 1319-1326.

35. Monroy-Cuadros M., Salazar A., Yilmaz S., McLaughlin K. Bladder vs enteric drainage in simultaneous pancreas-kidney transplantation // Nephrol. Dial. Transplant. - 2006. - Vol. 21. - P. 483-487.

36. Nathan D.M., Cleary P.A., Backlund J.Y., Genuth S.M., Lachin J.M., Orchard T.J., Raskin P., Zinman B. Diabetes Control and Complications Trial/Epidemiology of Diabetes Intervention and Complications (DCCT/EDIC) Study Research Group: Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes // N. Engl. J. Med. - 2005. - Vol. 353. - P. 2643-2653.

37. Luan F.L., Miles C.D., Cibrik D.M., Ojo A.O. Impact of simultaneous pancreas and kidney transplantation on cardiovascular risk factors in patients with type 1 diabetes mellitus // Transplantation. - 2007. - Vol. 84. - P. 541-544.

38. Fiorina P., Shapiro A.M.J., Ricordi C., Secchi A. The Clinical Impact of Islet Transplantation // American Journal of Transplantation. - 2008. - Vol. 8 (10). - P. 1990-1997.

39. Mahfuzul H.K., Harlan D.M. Counterpoint: Clinical Islet Transplantation: Not Ready for Prime Time // Diabetes Care. - 2009. - Vol. 32. - P. 1570-1574.

40. Dixon B Kaufman, MD, PhD, Director of Pancreas Transplantation, Professor, Department of Surgery, Division of Transplantation, Feinberg School of Medicine, Northwestern University Pancreas Transplantation. Contributor Information and Disclosures. Updated: Nov 11, 2009.

41. Dean P.G., Kudva Y.C., Larson T.S., Kremers W.K., Stegall M.D. Posttransplant diabetes mellitus after pancreas transplantation // Am. J. Transplant. - 2008. - Vol. 8(1). - P. 175-82.

42. Hyoung-I Kim , Jae Eun Yu, Chung-Gyu Park and Sang-Joon Kim. Comparison of Four Pancreatic Islet Implantation Sites // J. Korean Med. Sci. - 2010. - Vol. 25. - P. 203-10.

43. Shapiro A.M., Lakey J.R., Ryan E.A., Korbutt G.S., Toth E., Warnock G.L., Kneteman N.M., Rajotte R.V. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen // N. Engl. J. Med. - 2000. - Vol. 343. - P. 230-238.

44. Robertson R.P. Islet Transplantation a Decade Later and Strategies for Filling a Half-full Glass // Diabetes. - 2010. - Vol. 59 (6). - P. 1285-1291.

45. Calafiore R., Basta G., Luca G. et al. Microencapsulated pancreatic islet allografts into nonimmunosuppressed patients with type 1 diabetes: First two cases // Diabetes Care. - 2006. - Vol. 29. - P. 137-138.

46. Rickels M.R., Schutta M.H., Markmann J.F., Barker C.F., Naji A., Teff K.L. -Cell function following human islet transplantation for type 1 diabetes // Diabetes. - 2005. - Vol. 54. - P. 100-106.

47. Deng S., Markmann J.F., Rickels M., Yeh H., Kim J.I., Lian M.M., Gu Y., Markmann E., Palanjian M., Barker C.F., Naji A. Islet alone versus islet after kidney transplantation: metabolic outcomes and islet graft survival // Transplantation. - 2009. - Vol. 88. - P. 820-825.


Review

For citations:


Kvaratskheliya M.V. Combined or isolated transplantation of pancreas and kidney at the terminal stage of diabetic nephropathy. Diabetes mellitus. 2010;13(4):76-82. (In Russ.)

Views: 799


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2072-0351 (Print)
ISSN 2072-0378 (Online)