Immunity-mediated diseases and human immunogenetics (accomplishments and prospects)
https://doi.org/10.14341/DM7775
Abstract
Type 1 diabetes mellitus (T1DM) was used from the viewpoint of human immunogenetics as an example of the most widely studied immunity-mediated disease. This was done in order to develop, approve and implement a new clinical approach to determine immunity-mediated susceptibility or resistance to autoimmune diseases. The approach is based on analysis of entire HLA-DRB1 genotypes (not separate HLA-DRB1 haplotypes) of the study participants. Therefore, more effective and personalised classification of T1DM risk groups was achieved by exclusion from significant contingents.
About the Authors
Ivan Ivanovich Dedov
Endocrinology Research Centre
Russian Federation
MD, PhD, Professor, Vice-President of Russian Academy of Sciences, Fellow of Russian Academy of Sciences, professor, director of Endocrinology Research Centre
Russian Federation
MD, PhD, Professor, Vice-President of Russian Academy of Sciences, Fellow of Russian Academy of Sciences, professor, director of Endocrinology Research Centre
Rakhim Musaevich Khaitov
National Research Centre – Institute of Immunology
Russian Federation
Russian Federation
MD, PhD, Professor, Fellow of Russian Academy of Sciences, professor, Research Director at Federal Institute of Immunology.
Leonid Petrovich Alexeev
National Research Centre – Institute of Immunology
Russian Federation
Russian Federation
MD, PhD, Professor, Corresponding Member of Russian Academy of Sciences, head of the Immunology department at Federal Institute of Immunology.
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Dedov I.I., Khaitov R.M., Alexeev L.P. Immunity-mediated diseases and human immunogenetics (accomplishments and prospects). Diabetes mellitus. 2016;19(1):8-15. (In Russ.) https://doi.org/10.14341/DM7775
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