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Сахарный диабет

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Инсулин деглудек/инсулин аспарт ? первый комбинированный препарат базального и прандиального аналогов инсулина

https://doi.org/10.14341/DM20144108-119

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Аннотация

Достижение оптимального гликемического контроля ? основная задача для предупреждения и замедления прогрессирования диабета и связанных с ним осложнений. Инсулинотерапия является самым эффективным способом достижения целей гликемического контроля. В свою очередь, оптимальная инсулинотерапия должна максимально точно имитировать физиологический профиль секреции инсулина, наблюдаемый у людей без сахарного диабета (СД). В связи с этим, разработка и внедрение аналогов инсулина, обладающих улучшенным профилем безопасности, предоставляет новые возможности в лечении диабета. Инсулин деглудек/инсулин аспарт (ИДегАсп, Райзодег?, Ново Нордиск, Дания) ? первый растворимый комбинированный препарат инсулина, содержащий 70% инсулина сверхдлительного действия деглудек и 30% аналога инсулина ультракороткого действия аспарт в одной инъекции, обеспечивающий потребность как в базальном, так и в прандиальном инсулине. В настоящем обзоре представлены результаты по эффективности, безопасности, переносимости и клинических преимуществах ИДегАсп. По данным программы клинических исследований, ИДегАсп обеспечивает достижение успешного контроля с преимуществом в отношении снижения содержания глюкозы плазмы натощак (ГПН) при использовании меньших доз и меньшего количества инъекций, а также ассоциируется со значительно меньшей частотой подтвержденных гипогликемий, в том числе ночных, по сравнению с существующими предварительно смешанными и базальными аналогами инсулина, а также обычной базис-болюсной терапией (при использовании вместе с инсулином аспарт). Результаты клинических исследований показывают, что ИДегАсп может быть логичным и обоснованным выбором для начала и интенсификации инсулинотерапии при СД 1 и 2 типа у пациентов, не достигших адекватного контроля при использовании максимальных доз пероральных сахароснижающих препаратов, а также простой альтернативой базис-болюсной терапии у пациентов, нуждающихся в интенсификации инсулинотерапии, особенно, когда соблюдение более сложного режима является трудновыполнимой задачей.

Об авторах

Иван Иванович Дедов
ФГБУ "Эндокринологический научный центр" Минздрава России, Москва
Россия
доктор медицинских наук, профессор, академик РАН, Директор ФГБУ ЭНЦ


Марина Владимировна Шестакова
https://www.researchgate.net/profile/Marina_Shestakova2
ФГБУ "Эндокринологический научный центр" Минздрава России; ГБОУ ВПО "Первый МГМУ им. И.М. Сеченова", Москва
Россия
доктор медицинских наук, профессор, член-корреспондент РАН, Директор Института диабета ФГБУ ЭНЦ, заведующая кафедрой детской эндокринологии с курсами диабетологии и эндокринологии ГБОУ ВПО "Первый МГМУ им. И.М. Сеченова"


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Для цитирования:


Дедов И.И., Шестакова М.В. Инсулин деглудек/инсулин аспарт ? первый комбинированный препарат базального и прандиального аналогов инсулина. Сахарный диабет. 2014;17(4):108-119. https://doi.org/10.14341/DM20144108-119

For citation:


Dedov I.I., Shestakova M.V. Insulin degludec/insulin aspart is the first co-formulation of basal and prandial insulin analogues. Diabetes mellitus. 2014;17(4):108-119. (In Russ.) https://doi.org/10.14341/DM20144108-119

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