Markers for hepatic autoimmune disorders in patients with type 1 diabetes mellitus
https://doi.org/10.14341/DM2014129-33
Abstract
Aim.
To assess the occurrence of autoantibodies characteristic of autoimmune hepatitis in patients with type 1 diabetes mellitus (T1DM), and to analyze clinical features of positive subjects.
Materials and Methods.
. 84 patients (39 male, 45 female) with T1DM were subdivided into two groups and underwent biochemical, immunologic and instrumental examination.
Results.
Markers for hepatic autoimmune disorders were found to be highly prevalent in patients with T1DM, even in those asymptomatic according to clinical and instrumental diagnostic methods.
Conclusion.
Our data suggests that T1DM patients are at higher risk of corresponding, though possibly asymptomatic autoimmune disorders.
To assess the occurrence of autoantibodies characteristic of autoimmune hepatitis in patients with type 1 diabetes mellitus (T1DM), and to analyze clinical features of positive subjects.
Materials and Methods.
. 84 patients (39 male, 45 female) with T1DM were subdivided into two groups and underwent biochemical, immunologic and instrumental examination.
Results.
Markers for hepatic autoimmune disorders were found to be highly prevalent in patients with T1DM, even in those asymptomatic according to clinical and instrumental diagnostic methods.
Conclusion.
Our data suggests that T1DM patients are at higher risk of corresponding, though possibly asymptomatic autoimmune disorders.
About the Authors
Olga Sergeevna Derevyanko
Endocrinology Research Centre
Russian Federation
Graduate student
Russian Federation
Graduate student
Nadejda Sergeevna Dalantaeva
Endocrinology Research Centre
Russian Federation
Graduate student
Russian Federation
Graduate student
Olga Nikolaevna Ivanova
Endocrinology Research Centre
Russian Federation
PhD in Biology, Leading Researcher, Head of the Laboratory of Genetics and Clinical Immunology
Russian Federation
PhD in Biology, Leading Researcher, Head of the Laboratory of Genetics and Clinical Immunology
Nikolay Petrovich Goncharov
Endocrinology Research Centre
Russian Federation
MD, PhD, Professor, Head of the Hormonal analysis laboratory
Russian Federation
MD, PhD, Professor, Head of the Hormonal analysis laboratory
Tatiana Vasil'evna Nikonova
Endocrinology Research Centre
Russian Federation
MD, PhD, Leading Researcher, Programm education and therapy department
Russian Federation
MD, PhD, Leading Researcher, Programm education and therapy department
Olga Mikhailovna Smirnova
Endocrinology Research Centre
Russian Federation
MD, PhD, Professor, Chief Researcher, Programm education and therapy department
Russian Federation
MD, PhD, Professor, Chief Researcher, Programm education and therapy department
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Supplementary files
Review
For citations:
Derevyanko O.S., Dalantaeva N.S., Ivanova O.N., Goncharov N.P., Nikonova T.V., Smirnova O.M. Markers for hepatic autoimmune disorders in patients with type 1 diabetes mellitus. Diabetes mellitus. 2014;17(1):29-33. (In Russ.) https://doi.org/10.14341/DM2014129-33
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