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Markers for hepatic autoimmune disorders in patients with type 1 diabetes mellitus

https://doi.org/10.14341/DM2014129-33

Abstract

Aim.
To assess the occurrence of autoantibodies characteristic of autoimmune hepatitis in patients with type 1 diabetes mellitus (T1DM), and to analyze clinical features of positive subjects.
Materials and Methods.
. 84 patients (39 male, 45 female) with T1DM were subdivided into two groups and underwent biochemical, immunologic and instrumental examination.
Results.
Markers for hepatic autoimmune disorders were found to be highly prevalent in patients with T1DM, even in those asymptomatic according to clinical and instrumental diagnostic methods.
Conclusion.
 Our data suggests that T1DM patients are at higher risk of corresponding, though possibly asymptomatic autoimmune disorders.

About the Authors

Olga Sergeevna Derevyanko
Endocrinology Research Centre
Russian Federation
Graduate student


Nadejda Sergeevna Dalantaeva
Endocrinology Research Centre
Russian Federation
Graduate student


Olga Nikolaevna Ivanova
Endocrinology Research Centre
Russian Federation
PhD in Biology, Leading Researcher, Head of the Laboratory of Genetics and Clinical Immunology


Nikolay Petrovich Goncharov
Endocrinology Research Centre
Russian Federation
MD, PhD, Professor, Head of the Hormonal analysis laboratory


Tatiana Vasil'evna Nikonova
Endocrinology Research Centre
Russian Federation
MD, PhD, Leading Researcher, Programm education and therapy department


Olga Mikhailovna Smirnova
Endocrinology Research Centre
Russian Federation
MD, PhD, Professor, Chief Researcher, Programm education and therapy department


References

1. Triolo TM, Armstrong TK, McFann K, Yu L, Rewers MJ, Klingensmith GJ, et al. Additional Autoimmune Disease Found in 33% of Patients at Type 1 Diabetes Onset. Diabetes Care 2011;34(5):1211-1213. Available from: http://care.diabetesjournals.org/cgi/doi/10.2337/dc10-1756 doi: 10.2337/dc10-1756.

2. Wägner AM, Santana A, Herńndez M, Wiebe JC, Nóvoa J, Mauricio D. Predictors of associated autoimmune diseases in families with type 1 diabetes: results from the Type 1 Diabetes Genetics Consortium. Diabetes Metab. Res. Rev 2011;27(5):493-498. Available from: http://doi.wiley.com/10.1002/dmrr.1189 PubMed PMID: 21744463. doi: 10.1002/dmrr.1189.

3. Barker JM. Type 1 Diabetes-Associated Autoimmunity: Natural History, Genetic Associations, and Screening. The Journal of Clinical Endocrinology & Metabolism 2006;91(4):1210-1217. Available from: http://press.endocrine.org/doi/abs/10.1210/jc.2005-1679 PubMed PMID: 16403820. doi: 10.1210/jc.2005-1679.

4. Лейшнер У. Аутоиммунный гепатит. Под ред. Шептулин А, Ситкин С. Университет Франкфурт-на-Майне; 2008. 40 с. [Leĭshner W. Autoimmunnyĭ hepatitis. Ed. by Sheptulin A, Sitkin S. University Frankfurt Maĭne; 2008. 40 p.]

5. Couto CA, Bittencourt PL, Porta G, Abrantes-Lemos CP, Carrilho FJ, Guardia BD, et al. Antismooth muscle and antiactin antibodies are indirect markers of histological and biochemical activity of autoimmune hepatitis. Hepatology 2013;59(2):592-600. Available from: http://doi.wiley.com/10.1002/hep.26666 doi: 10.1002/hep.26666.

6. Liu FPM, de Miranda DM, Fagundes ED, Ferreira AR, Simões e Silva AC . Autoimmune hepatitis in childhood: The role of genetic and immune factors. World J Gastroenterol 2013;19(28):4455-4463. Available from: http://www.wjgnet.com/1007-9327/full/v19/i28/4455.htm PubMed PMID: 23901220. doi: 10.3748/wjg.v19.i28.4455.

7. Czaja A. Diagnosis and treatment of autoimmune hepatitis. Hepatology 2002;36(2):479-497. Available from: http://doi.wiley.com/10.1053/jhep.2002.34944 doi: 10.1053/jhep.2002.34944.

8. Gabir MM, Hanson RL, Dabelea D, Imperatore G, Roumain J, Bennett PH, et al. The 1997 American Diabetes Association and 1999 World Health Organization criteria for hyperglycemia in the diagnosis and prediction of diabetes. Diabetes Care 2000;23(8):1108-1112. Available from: http://care.diabetesjournals.org/cgi/doi/10.2337/diacare.23.8.1108 doi: 10.2337/diacare.23.8.1108.

9. Kessler WR, Cummings OW, Eckert G, Chalasani N, Lumeng L, Kwo PY. Fulminant hepatic failure as the initial presentation of acute autoimmune hepatitis. Clinical Gastroenterology and Hepatology 2004;2(7):625-631. Available from: http://linkinghub.elsevier.com/retrieve/pii/S1542356504002460 PubMed PMID: 15224287. doi: 10.1016/S1542-3565(04)00246-0.

10. Ивашкина ВТ. Болезни печени и желчевыводящих путей: Руководство для врачей. 2-е изд., испр. и доп. – Москва: Издательский Дом «М-Вести»; 2005. [Ivashkina VT. Bolezni pecheni i zhelchevyvodyashchikh putey: Rukovodstvo dlya vrachey. 2nd ed. Moscow: M-Vesti; 2005.]

11. Abdo A, Meddings J, Swain M. Liver abnormalities in celiac disease. Clin. Gastroenterol. Hepatol. 2004;2(2):107-112. Available from: http://linkinghub.elsevier.com/retrieve/pii/S1542356503003136 PubMed PMID: 15017614. doi: 10.1016/S1542-3565(03)00313-6.

12. Obermayer–Straub P, Perheentupa J, Braun S, Kayser A, Barut A, Loges S, et al. Hepatic autoantigens in patients with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. Gastroenterology 2001;121(3):668-677. Available from: http://linkinghub.elsevier.com/retrieve/pii/S0016508501671221 PubMed PMID: 11522751. doi: 10.1053/gast.2001.27103.

13. Czaja AJ. Challenges in the diagnosis and management of autoimmune hepatitis. Can J Gastroenterol 2013;27(9):531-539. PubMed PMID: 24078938.


Supplementary files

Review

For citations:


Derevyanko O.S., Dalantaeva N.S., Ivanova O.N., Goncharov N.P., Nikonova T.V., Smirnova O.M. Markers for hepatic autoimmune disorders in patients with type 1 diabetes mellitus. Diabetes mellitus. 2014;17(1):29-33. (In Russ.) https://doi.org/10.14341/DM2014129-33

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ISSN 2072-0351 (Print)
ISSN 2072-0378 (Online)