Effects of growth factors and cytokins on soft tissue regeneration in patients with diabetes mellitus
https://doi.org/10.14341/DM2014157-62
Abstract
Delayed wound healing is characteristic of a glycemic disorder and often results in trophic ulcer formation, ? a process still poorly understood but likely multifaceted. Current review addresses latest reports from cellular and molecular studies of soft tissue regeneration in patients with diabetes mellitus.
About the Authors
Ekaterina Leonidovna Zaytseva
Endocrinology Research Centre
Russian Federation
Graduate student in Diabetic Foot Department, Diabetes Institution
Russian Federation
Graduate student in Diabetic Foot Department, Diabetes Institution
Alla Yur'evna Tokmakova
Endocrinology Research Centre
Russian Federation
MD, PhD, Senior Researcher in Diabetic Foot Department, Diabetes Institution
Russian Federation
MD, PhD, Senior Researcher in Diabetic Foot Department, Diabetes Institution
References
1. Falanga V. Wound healing and its impairment in the diabetic foot. Lancet 2005;366(9498):1736-1743. Available from: http://linkinghub.elsevier.com/retrieve/pii/S0140673605677008 PubMed PMID: 16291068. doi: 10.1016/S0140-6736(05)67700-8.
2. Cavanagh PR, Raymann G. The foot in diabetes, 4th edition. Editors Andrew J.M.Boulton, New and alternative treatments for diabetic foot ulcers: Hormones and growth factors. John Willey& sons, Ltd; 2006.
3. Galkowska H, Wojewodzka U, Olszewski WL. Chemokines, cytokines, and growth factors in keratinocytes and dermal endothelial cells in the margin of chronic diabetic foot ulcers. Wound Repair Regen 2006;14(5):558-565. Available from: http://www.nlm.nih.gov/medlineplus/diabeticfoot.html PubMed PMID: 17014667. doi: 10.1111/j.1743-6109.2006.00155.x.
4. Ferguson MW, Herrick SE, Spencer MJ, Shaw JE, Boulton AJ, Sloan P. The histology of diabetic foot ulcers. Diabet Med 1996;13 Suppl 1. Available from: http://www.nlm.nih.gov/medlineplus/diabeticfoot.html PubMed PMID: 8741826.
5. Loots MA, Lamme EN, Zeegelaar J, Mekkes JR, Bos JD, Middelkoop E. Differences in cellular infiltrate and extracellular matrix of chronic diabetic and venous ulcers versus acute wounds. J Invest Dermatol 1998;111(5):850-857. Available from: http://www.nlm.nih.gov/medlineplus/diabeticfoot.html PubMed PMID: 9804349. doi: 10.1046/j.1523-1747.1998.00381.x.
6. Werner S. Grose R. Regulation of wound healing by growth factors and cytokines. Physiol. Rev 2003;83(3):835-870. Available from: http://physrev.physiology.org/cgi/pmidlookup?view=long&pmid=12843410 PubMed PMID: 12843410. doi: 10.1152/physrev.00031.2002.
7. Blakytny R, Jude E. The molecular biology of chronic wounds and delayed healing in diabetes. Diabet Med 2006;23(6):594-608. Available from: http://doi.wiley.com/10.1111/j.1464-5491.2006.01773.x doi: 10.1111/j.1464-5491.2006.01773.x.
8. Fukumura D, Gohongi T, Kadambi A, Izumi Y, Ang J, Yun CO, et al. Predominant role of endothelial nitric oxide synthase in vascular endothelial growth factor-induced angiogenesis and vascular permeability. Proceedings of the National Academy of Sciences 2001 Feb;98(5):2604-2609. Available from: http://www.pnas.org/cgi/pmidlookup?view=long&pmid=11226286 PubMed PMID: 11226286. doi: 10.1073/pnas.041359198.
9. Maruyama K, Asai J, Ii M, Thorne T, Losordo DW, D' Amore PA. Decreased Macrophage Number and Activation Lead to Reduced Lymphatic Vessel Formation and Contribute to Impaired Diabetic Wound Healing. The American Journal of Pathology 2007;170(4):1178-1191. Available from: http://linkinghub.elsevier.com/retrieve/pii/S0002944010613338 PubMed PMID: 17392158. doi: 10.2353/ajpath.2007.060018.
10. Gibran NS, Jang YC, Isik FF, Greenhalgh DG, Muffley LA, Underwood RA, et al. Diminished neuropeptide levels contribute to the impaired cutaneous healing response associated with diabetes mellitus. J Surg Res 2002;108(1):122-128. Available from: http://www.scholaruniverse.com/ncbi-linkout?id=12443724 PubMed PMID: 12443724.
11. Arnold F, West DC. Angiogenesis in wound healing. Pharmacology & Therapeutics 1991;52(3):407-422. Available from: http://linkinghub.elsevier.com/retrieve/pii/016372589190034J PubMed PMID: 1726477. doi: 10.1016/0163-7258(91)90034-J.
12. Dinh T, Tecilazich F, Kafanas A, Doupis J, Gnardellis C, Leal E, et al. Mechanisms Involved in the Development and Healing of Diabetic Foot Ulceration. Diabetes 2012;61(11):2937-2947. Available from: http://diabetes.diabetesjournals.org/cgi/doi/10.2337/db12-0227 doi: 10.2337/db12-0227.
13. Abd-El-Aleem SA, Ferguson MWJ, Appleton I, Kairsingh S, Jude EB, Jones K, et al. Expression of nitric oxide synthase isoforms and arginase in normal human skin and chronic venous leg ulcers. J. Pathol 2000;191(4):434-442. Available from: http://doi.wiley.com/10.1002/1096-9896%282000%299999%3A9999%3C%3A%3AAID-PATH654%3E3.0.CO%3B2-S PubMed PMID: 10918219. doi: 10.1002/1096-9896(2000)9999:99993.0.CO;2-S.
14. Moulin V. Growth factors in skin wound healing. Eur J Cell Biol 1995;68(1):1-7. PubMed PMID: 8549585.
15. Jude EB, Boulton AJM, Ferguson MWJ, Appleton I. The role of nitric oxide synthase isoforms and arginase in the pathogenesis of diabetic foot ulcers: possible modulatory effects by transforming growth factor beta 1. Diabetologia 1999;42(6):748-757. Available from: http://link.springer.com/10.1007/s001250051224 PubMed PMID: 10382596. doi: 10.1007/s001250051224.
16. Veves A, Akbari CM, Primavera J, Donaghue VM, Zacharoulis D, Chrzan JS, et al. Endothelial dysfunction and the expression of endothelial nitric oxide synthetase in diabetic neuropathy, vascular disease, and foot ulceration. Diabetes 1998;47(3):457-463. Available from: http://diabetes.diabetesjournals.org/cgi/doi/10.2337/diabetes.47.3.457 PubMed PMID: 9519754. doi: 10.2337/diabetes.47.3.457.
17. Mutsaers SE, Bishop JE, McGrouther G, Laurent GJ. Mechanisms of tissue repair: from wound healing to fibrosis. The International Journal of Biochemistry & Cell Biology 1997;29(1):5-17. Available from: http://linkinghub.elsevier.com/retrieve/pii/S135727259600115X PubMed PMID: 9076937. doi: 10.1016/S1357-2725(96)00115-X.
18. Engelhardt E, Toksoy A, Goebeler M, Debus S, Bröcker E, Gillitzer R. Chemokines IL-8, GROα, MCP-1, IP-10, and Mig Are Sequentially and Differentially Expressed During Phase-Specific Infiltration of Leukocyte Subsets in Human Wound Healing. The American Journal of Pathology 1998;153(6):1849-1860. Available from: http://linkinghub.elsevier.com/retrieve/pii/S0002944010656994 doi: 10.1016/S0002-9440(10)65699-4.
19. Wetzler C, Kampfer H, Stallmeyer B, Pfeilschifter J, Frank S. Large and Sustained Induction of Chemokines during Impaired Wound Healing in the Genetically Diabetic Mouse: Prolonged Persistence of Neutrophils and Macrophages during the Late Phase of Repair. J Invest Dermatol 2000;115(2):245-253. Available from: http://www.nature.com/doifinder/10.1046/j.1523-1747.2000.00029.x PubMed PMID: 10951242. doi: 10.1046/j.1523-1747.2000.00029.x.
20. Barker JN, Jones ML, Mitra R, Crockett-Torabe E, Fautone JC, Kunkel SL, et al. Dixit VM, Nickoloff BJ. Modulation of keratinocyte-derived interleukin-8 which is chemotactic for neutrophils and T lymphocytes. Am J Pathol 1991;139(4):869-876. Available from: http://europepmc.org/abstract/MED/1681733 PubMed PMID: 1681733.
21. Nomura S, Shouzu A, Omoto S, Nishikawa M, Fukuhara S. Significance of chemokines and activated platelets in patients with diabetes. Clin Exp Immunol 2000;121(3):437-443. Available from: http://doi.wiley.com/10.1046/j.1365-2249.2000.01324.x PubMed PMID: 10971508. doi: 10.1046/j.1365-2249.2000.01324.x.
22. Michel G, Kemény L, Peter RU, Beetz A, Ried C, Arenberger P, et al. Interleukin-8 receptor-mediated chemotaxis of normal human epidermal cells. FEBS Letters 1992;305(3):241-243. Available from: http://linkinghub.elsevier.com/retrieve/pii/0014579392806779 PubMed PMID: 1299623. doi: 10.1016/0014-5793(92)80677-9.
23. Pierce GF, Brown D, Mustoe TA. Quantitative analysis of inflammatory cells influx, procollagen type-I synthesis, and cross-linking in incisional wounds—influence of PDGF-BB and TGF-b1 therapy. J Lab Clin Med 1991;117:373-382.
24. Jude EB, Blakytny R, Bulmer J, Boulton AJM, Ferguson MWJ. Transforming growth factor-beta 1, 2, 3 and receptor type I and II in diabetic foot ulcers. Diabet Med 2002;19(6):440-447. Available from: http://doi.wiley.com/10.1046/j.1464-5491.2002.00692.x PubMed PMID: 12060054. doi: 10.1046/j.1464-5491.2002.00692.x.
25. de Waal Malefyt, R. , Abrams J, Bennett B, Figdor CG, de Vries JE. Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. J Exp Med 1991;174(5):1209-1220. Available from: http://jem.rupress.org/cgi/pmidlookup?view=long&pmid=1940799 PubMed PMID: 1940799. doi: 10.1084/jem.174.5.1209.
26. Shure D, Senior RM, Griffin GL, Deuel TF. PDGF AA homodimers are potent chemoattractants for fibroblasts and neutrophils, and for monocytes activated by lymphocytes or cytokines. Biochemical and Biophysical Research Communications 1992;186(3):1510-1514. Available from: http://linkinghub.elsevier.com/retrieve/pii/S0006291X05815773 doi: 10.1016/S0006-291X(05)81577-3.
27. Blakytny R, Jude EB, Martin Gibson, J, , Boulton AJM, Ferguson MWJ. Lack of insulin-like growth factor 1 (IGF1) in the basal keratinocyte layer of diabetic skin and diabetic foot ulcers. J. Pathol 2000;190(5):589-594. Available from: http://doi.wiley.com/10.1002/%28SICI%291096-9896%28200004%29190%3A5%3C589%3A%3AAID-PATH553%3E3.0.CO%3B2-T PubMed PMID: 10727985. doi: 10.1002/(SICI)1096-9896(200004)190:53.0.CO;2-T.
28. Yano S, Komine M, Fujimoto M, Okochi H, Tamaki K. Interleukin 15 induces the signals of epidermal proliferation through ERK and PI 3-kinase in a human epidermal keratinocyte cell line, HaCaT. Biochemical and Biophysical Research Communications 2003;301(4):841-847. Available from: http://linkinghub.elsevier.com/retrieve/pii/S0006291X03000603 doi: 10.1016/S0006-291X(03)00060-3.
29. Galkowska H, Olszewsk WL, Wojewodzka U, Mijal J, Filipiuk E. Expression of apoptosis- and cell cycle-related proteins in epidermis of venous leg and diabetic foot ulcers. Surgery 2003;134(2):213-220. Available from: http://linkinghub.elsevier.com/retrieve/pii/S0039606003001818 PubMed PMID: 12947320. doi: 10.1067/msy.2003.223.
30. Brem H, Stojadinovic O, Diegelmann RF, Entero H, Lee B, Pastar I, et al. Molecular markers in patients with chronic wounds to guide surgical debridement.. Mol Med 2007;13(1-2):30-39. Available from: http://www.molmed.org/content/pdfstore/30-39.Brem.00051.PDF PubMed PMID: 17515955. doi: 10.2119/2006-00054.Brem.
31. Bamberger C, Scharer A, Antsiferova M, et al. Activin controls skin morphogenesis and wound repair predominantly via stromal cells and in a concentration-dependent manner via keratinocytes. Am J Pathol 2005;167(3):733-747. Available from: http://linkinghub.elsevier.com/retrieve/pii/S0002944010620470 doi: 10.1016/S0002-9440(10)62047-0.
32. Liu Y, Min D, Bolton T, Nube V, Twigg SM, Yue DK, et al. Increased Matrix Metalloproteinase-9 Predicts Poor Wound Healing in Diabetic Foot Ulcers. Diabetes Care 2009 янв.;32(1):117-119. Available from: http://care.diabetesjournals.org/cgi/doi/10.2337/dc08-0763 PubMed PMID: 18835949. doi: 10.2337/dc08-0763.
33. Muller M, Trocme C, Lardy B, Morel F, Halimi S, Benhamou PY. Matrix metalloproteinases and diabetic foot ulcers: the ratio of MMP-1 to TIMP-1 is a predictor of wound healing. Diabetic Med 2008;25(4):419-426. Available from: http://doi.wiley.com/10.1111/j.1464-5491.2008.02414.x PubMed PMID: 18387077. doi: 10.1111/j.1464-5491.2008.02414.x.
34. Li Z., Guo S., Yao F., Zhang Y., Li T.. Increased ratio of serum matrix metalloproteinase-9 against TIMP-1 predicts poor wound healing in diabetic foot ulcers. Journal of Diabetes and Its Complications 27.2013, 380–382
Supplementary files
Review
For citations:
Zaytseva E.L., Tokmakova A.Yu. Effects of growth factors and cytokins on soft tissue regeneration in patients with diabetes mellitus. Diabetes mellitus. 2014;17(1):57-62. (In Russ.) https://doi.org/10.14341/DM2014157-62
Views:
1105
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND 4.0).
Email this article 
