Postprandial secretion of insulin and peptide YY when taking erythritol and sucrose

AIM. To study the effect of the non-calorie sweetener erythritol and the combination of erythritol and sucrose on postprandial secretion of insulin and peptide-YY (PYY).

MATERIALS AND METHODS. A comparative study was conducted to assess the effect of erythritol, sucrose and a combination of erythritol and sucrose on postprandial glucose, IRI and PYY levels. The participants were selected from among healthy volunteers, aged 18 to 35 years. If the participants met the selection criteria, further stages of the study were carried out. During the study, each participant took a solution of sucrose 75 g, erythritol 75 g or a mixture of sucrose and erythritol (75 g and 25 g, respectively). Further determination of glucose and insulin was carried out every 30 minutes, so glucose, insulin and PYY values were determined initially and at the 30th, 60th, 90th and 120th minutes.

RESULTS. Data were obtained confirming the absence of the effect of erythritol on postprandial secretion of insulin and glucose. In our work, we also demonstrated a decrease in postprandial glycemia when taking sucrose and erythritol together. Sucrose and erythritol equally stimulated PYY secretion.

CONCLUSION. Our data show that erythritol can be considered as an optimal sugar substitute in people with impaired carbohydrate metabolism and obesity.

1. Obesity and overweight [Internet]; World Health Organisation [cited 2024 Sep 20]. Available from: https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight

2. Use of non-sugar sweeteners: WHO guideline. Geneva: World Health Organization; 2023. Available at: https://www.who.int/publications-detail-redirect/9789240073616. Accessed September 24, 2024.

3. Livesey G. Health potential of polyols as sugar replacers, with emphasis on low glycaemic properties. Nutr Res Rev. 2003. https://doi.org/10.1079/nrr200371

4. Bornet FR, Blayo A, Dauchy F, Slama G. Plasma and urine kinetics of erythritol after oral ingestion by healthy humans. Regul Toxicol Pharmacol. 1996;24(2 Pt 2):S280-S285. https://doi.org/10.1006/rtph.1996.0109

5. Hootman KC, Trezzi JP, Kraemer L, et al. Erythritol is a pentose-phosphate pathway metabolite and associated with adiposity gain in young adults. Proc Natl Acad Sci USA. 2017. https://doi.org/10.1073/pnas.1620079114

6. Wölnerhanssen BK, Drewe J, Verbeure W, et al. Gastric emptying of solutions containing the natural sweetener erythritol and effects on gut hormone secretion in humans: A pilot dose‐ranging study. Diabetes, Obes Metab. 2021;23(6):1311-1321 https://doi.org/10.1111/dom.14342

7. Noda K, Nakayama K, Oku T. Serum glucose and insulin levels and erythritol balance after oral administration of erythritol in healthy subjects. Eur J Clin Nutr. 1994.

8. Wölnerhanssen BK, Cajacob L, Keller N, et al. Gut hormone secretion, gastric emptying, and glycemic responses to erythritol and xylitol in lean and obese subjects. Am J Physiol Metab. 2016;310(11):E1053-E1061. https://doi.org/10.1152/ajpendo.00037.2016

9. Ishikawa M, Miyashita M, Kawashima Y, et al. Effects of Oral Administration of Erythritol on Patients with Diabetes. Regul Toxicol Pharmacol. 1996;24(2):S303-S308. https://doi.org/10.1006/rtph.1996.0112

10. Livesey G. Health potential of polyols as sugar replacers, with emphasis on low glycaemic properties. Nutr Res Rev. 2003;16(2):163-91. https://doi.org/10.1079/NRR200371

11. Wen H, Tang B, Stewart AJ, et al. Erythritol Attenuates Postprandial Blood Glucose by Inhibiting α-Glucosidase. J Agric Food Chem. 2018. https://doi.org/10.1021/acs.jafc.7b05033

12. Chukwuma CI, Mopuri R, Nagiah S, et al. Erythritol reduces small intestinal glucose absorption, increases muscle glucose uptake, improves glucose metabolic enzymes activities and increases expression of Glut-4 and IRS-1 in type 2 diabetic rats. Eur J Nutr. 2018;57(7):2431-2444. https://doi.org/10.1007/s00394-017-1516-x

13. Bordier V, Teysseire F, Schlotterbeck G, et al. Effect of a Chronic Intake of the Natural Sweeteners Xylitol and Erythritol on Glucose Absorption in Humans with Obesity. Nutrients. 2021;13(11):3950. https://doi.org/10.3390/nu13113950

14. Raybould HE. Gut chemosensing: Interactions between gut endocrine cells and visceral afferents. Auton Neurosci. 2010;153(1-2):41-46. https://doi.org/10.1016/j.autneu.2009.07.007

15. Rehfeld JF. Incretin physiology beyond glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide: cholecystokinin and gastrin peptides. Acta Physiol (Oxf). 2011;201(4):405-411. https://doi.org/10.1111/j.1748-1716.2010.02235.x

16. Wu T, Zhao BR, Bound MJ, et al. Effects of different sweet preloads on incretin hormone secretion, gastric emptying, and postprandial glycemia in healthy humans. Am J Clin Nutr. 2012;95(1):78-83. https://doi.org/10.3945/ajcn.111.021543

17. Wu T, Bound MJ, Zhao BR, et al. Effects of a D-xylose preload with or without sitagliptin on gastric emptying, glucagon-like peptide-1, and postprandial glycemia in type 2 diabetes. Diabetes Care. 2013;36(7):1913-1918. https://doi.org/10.2337/dc12-2294

18. Degen L, Oesch S, Casanova M, et al. Effect of peptide YY3-36 on food intake in humans. Gastroenterology. 2005;129(5):1430-1436. https://doi.org/10.1053/j.gastro.2005.09.001