diaendoСахарный диабетDiabetes mellitus2072-03512072-0378Endocrinology research centre10.14341/DM9846diaendo-9846Research ArticleОбзорыReviewСердечная недостаточность при диабете: от повышенного риска до цели леченияHeart failure in diabetes: From an increased risk to a treatment targethttps://orcid.org/0000-0002-8667-633XStandlEberhard

MD, PhD

eberhard.standl@lrz.uni-muenchen.de<p>Munich Diabetes Research Group e.V. at Helmholtz Center</p>Germany201817122018215399403Copyright &#x00A9; Standl E., 20182018Standl E.Standl E.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.dia-endojournals.ru/jour/article/view/9846

Сердечная недостаточность (СН) является одной из наиболее распространенных коморбидностей сахарного диабета 2 типа (СД2). Неадекватный гликемический контроль может ухудшать исходы СН и повышать риск госпитализаций. За последнее десятилетие появилось несколько препаратов для лечения СД2, и их сердечно-сосудистая безопасность становится причиной беспокойства. По этой причине FDA поручило определить профиль сердечно-сосудистой безопасности и соотношение риск-польза для этих препаратов путем проведения специально разработанных исследований сердечно-сосудистых исходов. Несмотря на то что мы получили некоторые данные из этих исследований, ни одно из них не включало СН в главные конечные точки, что отражает необходимость проведения исследований, сфокусированных на СН. В данном обзоре кратко обсуждаются результаты исследования сердечно-сосудистых исходов в контексте СН.

Heart failure (HF) is one of the most common comorbidities of type 2 diabetes mellitus (T2DM) and poor glycaemic control can worsen the HF outcomes and increase the risk of hospitalisations. With the entry of several antihyperglycaemic agents for the management of T2DM over the last decade, there has been an increasing concern regarding the cardiovascular (CV) safety profile of these agents. In view of this, FDA mandated the demonstration of cardiovascular risk-benefit profile of these agents through specifically designed CV outcome trials. Although we have several findings from these trials, none of them included HF as a primary endpoint indicating the need of trials focusing on HF. Here, we briefly discuss the results of the CV outcome trials in the context of HF.

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The authors declare that there are no conflicts of interest present.